A5082838156- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Child Nutrition and Feeding Issues
- Metastasis and carcinoma case studies
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Gastrointestinal motility and disorders
- Lung Cancer Treatments and Mutations
- Voice and Speech Disorders
- Whipple's Disease and Interleukins
- Eosinophilic Disorders and Syndromes
- Transplantation: Methods and Outcomes
- Congenital gastrointestinal and neural anomalies
- COVID-19 and healthcare impacts
- Appendicitis Diagnosis and Management
- Immune Cell Function and Interaction
- Spinal Fractures and Fixation Techniques
University of Padua
2016-2025
Azienda Ospedaliera di Padova
2008-2023
Istituto Oncologico Veneto
2005
Istituti di Ricovero e Cura a Carattere Scientifico
2005
University of Parma
2004
University of Southern California
1993-1998
Many experts consider laparoscopic Heller's myotomy (LHM) to be superior pneumatic dilation for the treatment of achalasia, and LHM is increasingly considered choice this disorder.We randomly assigned patients with newly diagnosed achalasia or Dor's fundoplication. Symptoms, including weight loss, dysphagia, retrosternal pain, regurgitation, were assessed use Eckardt score (which ranges from 0 12, higher scores indicating more pronounced symptoms). The primary outcome was therapeutic success...
<h3>Objective</h3> Achalasia is a chronic motility disorder of the oesophagus for which laparoscopic Heller myotomy (LHM) and endoscopic pneumodilation (PD) are most commonly used treatments. However, prospective data comparing their long-term efficacy lacking. <h3>Design</h3> 201 newly diagnosed patients with achalasia were randomly assigned to PD (n=96) or LHM (n=105). Before randomisation, symptoms assessed using Eckardt score, functional test performed quality life was assessed. The...
Achalasia is a relatively rare primary motor esophageal disorder, characterized by absence of relaxations the lower sphincter and peristalsis along body. As result, patients typically present with dysphagia, regurgitation occasionally chest pain, pulmonary complication malnutrition. New diagnostic methodologies therapeutic techniques have been recently added to armamentarium for treating achalasia. With aim offer clinicians an up-to-date framework making informed decisions on management this...
In Brief Objective: To compare laparoscopic cardia myotomy and fundoplication with botulinum toxin (BoTx) injection in patients esophageal achalasia. Summary Background Data: Although is thought to offer better results, recent studies have reported 80% success rates after 2 BoTx injections a month apart. No randomized controlled trials comparing the treatments been published so far. Materials Methods: Newly diagnosed achalasia were randomly assigned or myotomy. Symptoms scored; lower...
In Brief Objective: Laparoscopic myotomy is the currently preferred treatment for achalasia. Our objectives were to assess long-term outcome of this operation and preoperative factors influencing said outcome. Methods: Demographic clinical characteristics data on prospectively collected patients undergoing laparoscopic achalasia at our institution from 1992 2007. Treatment failure was defined as a postoperative symptom score higher than 10th percentile (>9). Logistic regression analysis used...
Objective To assess the causes of failure laparoscopic Heller myotomy and to verify whether endoscopic pneumatic dilation is a feasible treatment. Summary Background Data Laparoscopic has proved an effective treatment for esophageal achalasia, with good or excellent results in 90% patients. The failures remains controversial, however. Methods From 1992 1999, 113 patients underwent achalasia. Ten (8.7%) reported dysphagia (n = 7) chest pain 3) median 5 months after surgery (range 1–12) were...
Intestinal metaplasia in the tubular esophagus is recognized precancerous lesion of adenocarcinoma Barrett esophagus. However, it not yet clear whether gastric cardia arises from same premalignant lesion, i.e., intestinal cardia. The purpose this study was to compare adenocarcinomas and at an early stage, when more likely that had been completely overgrown by tumor.The authors compared epidemiologic, clinical, pathologic features stage 42 patients who underwent resection surgery. presence...
OBJECTIVE The loss of myenteric neurons in the lower esophageal sphincter (LES) characterizes achalasia, an motor disorder. Because presence lymphocytic infiltrates suggests immuno-mediated mechanism ongoing at sites disease, we investigated T-cell receptor (TCR) repertoire and ability to recognize human herpes virus type 1 (HSV-1) antigens LES-infiltrating T lymphocytes achalasia patients. METHODS Fifty-nine patients with idiopathic 38 heart-beating cadaveric multiorgan donors (controls)...
Abstract Background The aims of this study were to evaluate the prevalence invasive cancer in patients with high-grade dysplasia Barrett's oesophagus and verify whether a second endoscopy multiple biopsies could improve accuracy preoperative diagnosis. In addition, mortality, morbidity survival rates having oesophageal resection recorded. Methods Fifteen observed from 1982 1998; first seven offered primary after other eight underwent median 12 examined. All later resection. Results Invasive...
Abstract A precise diagnosis is key to the successful treatment of achalasia. Barium swallow, upper endoscopy and high‐resolution manometry provide necessary information about a patient's anatomy, absence other diseases, type achalasia (I, II, III). High‐resolution also has prognostic value, best results being obtained in II according Chicago classification. Abdominal CT scanning endoscopic ultrasound might be warranted if an underlying malignancy suspected.