A5061868811- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Gastrointestinal motility and disorders
- Respiratory and Cough-Related Research
- Renal function and acid-base balance
- Financial Crisis of the 21st Century
- Autoimmune and Inflammatory Disorders Research
- Infection Control and Ventilation
- Pharmacological Effects of Natural Compounds
- COVID-19 and healthcare impacts
- Biochemical Analysis and Sensing Techniques
- Adolescent and Pediatric Healthcare
- Herbal Medicine Research Studies
- Respiratory Support and Mechanisms
- Parvovirus B19 Infection Studies
- Migration, Policy, and Dickens Studies
Universitair Ziekenhuis Leuven
2025
KU Leuven
2012-2019
<h3>Objective</h3> Achalasia is a chronic motility disorder of the oesophagus for which laparoscopic Heller myotomy (LHM) and endoscopic pneumodilation (PD) are most commonly used treatments. However, prospective data comparing their long-term efficacy lacking. <h3>Design</h3> 201 newly diagnosed patients with achalasia were randomly assigned to PD (n=96) or LHM (n=105). Before randomisation, symptoms assessed using Eckardt score, functional test performed quality life was assessed. The...
Achalasia is a relatively rare primary motor esophageal disorder, characterized by absence of relaxations the lower sphincter and peristalsis along body. As result, patients typically present with dysphagia, regurgitation occasionally chest pain, pulmonary complication malnutrition. New diagnostic methodologies therapeutic techniques have been recently added to armamentarium for treating achalasia. With aim offer clinicians an up-to-date framework making informed decisions on management this...
ABSTRACT Introduction The Leuven Consensus provides a classification scheme for the diagnosis of pharyngeal and upper esophageal sphincter (UES) motor disorders using metrics derived from high‐resolution manometry‐impedance (P‐HRM‐I). Methods Twenty‐six experts with broad multidisciplinary backgrounds contributed their knowledge experience to this initiative via formal deliberative Delphi process. Guidance on swallow assessment protocol as well diagnostic criteria UES dysfunction contractile...
The COVID-19 pandemic, declared by WHO on March 13, 2020, had a major global impact the healthcare system and services. In acute phase, presence of SARS-CoV-2 virus in aerodigestive tract limited activities gastroenterology clinic procedures to emergencies only. Motility function testing was interrupted as we enter recovery restarting these requires safety-focused approach with adequate infection prevention for patients professionals.We summarized knowledge risk spread motility functional...
Abstract Background Achalasia is a rare motility disorder characterized by myenteric neuron and interstitial cells of Cajal ( ICC ) abnormalities leading to deranged/absent peristalsis lack relaxation the lower esophageal sphincter. The mechanisms contributing neuronal changes in achalasia are only partially understood. Our goal was identify novel molecular features occurring patients with primary achalasia. Methods Esophageal full‐thickness biopsies from 42 (22 females; age range: 16‐82...
Achalasia patients with longstanding disease are considered to be at risk for developing esophageal cancer. Endoscopic screening is not standardized and detection of dysplastic lesions difficult, which Lugol chromoendoscopy could helpful. Aim was evaluate the efficacy dysplasia carcinoma in achalasia using chromoendoscopy.In this cohort study underwent three-annual by between January 2000 March 2016. Patients low-grade (LGD) yearly screening, high-grade (HGD) or were treated.In total, 230...
Abstract Background A recent multicenter randomized trial in achalasia patients has shown that pneumatic dilation resulted equivalent relief of symptoms compared to laparoscopic Heller myotomy. Additionally, the cost each treatment should be also taken consideration. Therefore, aim present study was perform an economic analysis European trial. Methods Patients with newly diagnosed were enrolled from 2003 2008 14 centers five countries and randomly assigned either ( PD ) or LHM ). The...
Postprandial stationary pH monitoring studies have identified the acid pocket. To what extent a similar pool of is present in fasting state or at night remains however unclear.The study was performed 9 HV without hiatal hernia. A pH-impedance-pressure catheter positioned Z-line. First, presence pocket monitored under conditions during 2 hours after ingestion standardized meal. Thereafter, equipment connected to an ambulatory device for 24-hour recording.Under conditions, postprandial 7 HV,...