A5070942695- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Tracheal and airway disorders
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- Lung Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Metastasis and carcinoma case studies
- Voice and Speech Disorders
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Hernia repair and management
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Surgical Treatments
- Cancer-related gene regulation
- Clinical practice guidelines implementation
Imperial College London
2015-2024
University Medical Center Utrecht
2024
St Mary's Hospital
2014-2023
St. Mary's Hospital
2017-2023
St Mary's Hospital
2021-2023
University of Padua
2006-2020
Queen Elizabeth the Queen Mother Hospital
2017
Southern Medical University
2017
Nanfang Hospital
2017
United Nations Industrial Development Organization
2017
Many experts consider laparoscopic Heller's myotomy (LHM) to be superior pneumatic dilation for the treatment of achalasia, and LHM is increasingly considered choice this disorder.We randomly assigned patients with newly diagnosed achalasia or Dor's fundoplication. Symptoms, including weight loss, dysphagia, retrosternal pain, regurgitation, were assessed use Eckardt score (which ranges from 0 12, higher scores indicating more pronounced symptoms). The primary outcome was therapeutic success...
<h3>Objective</h3> Achalasia is a chronic motility disorder of the oesophagus for which laparoscopic Heller myotomy (LHM) and endoscopic pneumodilation (PD) are most commonly used treatments. However, prospective data comparing their long-term efficacy lacking. <h3>Design</h3> 201 newly diagnosed patients with achalasia were randomly assigned to PD (n=96) or LHM (n=105). Before randomisation, symptoms assessed using Eckardt score, functional test performed quality life was assessed. The...
Achalasia is a relatively rare primary motor esophageal disorder, characterized by absence of relaxations the lower sphincter and peristalsis along body. As result, patients typically present with dysphagia, regurgitation occasionally chest pain, pulmonary complication malnutrition. New diagnostic methodologies therapeutic techniques have been recently added to armamentarium for treating achalasia. With aim offer clinicians an up-to-date framework making informed decisions on management this...
Achalasia is a primary motor disorder of the oesophagus characterised by absence peristalsis and insufficient lower oesophageal sphincter relaxation. With new advances developments in achalasia management, there an increasing demand for comprehensive evidence-based guidelines to assist clinicians patient care.Guidelines were established working group representatives from United European Gastroenterology, Society Neurogastroenterology Motility, Gastrointestinal Abdominal Radiology Association...
In Brief Objective: To compare laparoscopic cardia myotomy and fundoplication with botulinum toxin (BoTx) injection in patients esophageal achalasia. Summary Background Data: Although is thought to offer better results, recent studies have reported 80% success rates after 2 BoTx injections a month apart. No randomized controlled trials comparing the treatments been published so far. Materials Methods: Newly diagnosed achalasia were randomly assigned or myotomy. Symptoms scored; lower...
Over a 17-year period, 92 patients with esophageal disease underwent colon interposition or bypass, each operation performed by the same surgeon. The indication was cure of cancer in 20 patients, relief dysphagia 55 (cancer 17 and benign 38), loss gastrointestinal (G.I.) continuity ten, tracheoesophageal fistula seven (malignant five, 2). thirty-day operative mortality rate 5%, hospital 9%. Graft necrosis occurred four whom later successful second reconstruction. Thirteen required subsequent...
In Brief Objective: Laparoscopic myotomy is the currently preferred treatment for achalasia. Our objectives were to assess long-term outcome of this operation and preoperative factors influencing said outcome. Methods: Demographic clinical characteristics data on prospectively collected patients undergoing laparoscopic achalasia at our institution from 1992 2007. Treatment failure was defined as a postoperative symptom score higher than 10th percentile (>9). Logistic regression analysis used...
Objective To assess the causes of failure laparoscopic Heller myotomy and to verify whether endoscopic pneumatic dilation is a feasible treatment. Summary Background Data Laparoscopic has proved an effective treatment for esophageal achalasia, with good or excellent results in 90% patients. The failures remains controversial, however. Methods From 1992 1999, 113 patients underwent achalasia. Ten (8.7%) reported dysphagia (n = 7) chest pain 3) median 5 months after surgery (range 1–12) were...
Traditionally esophageal perforation is a rare clinical emergency that confers high rate of mortality and major morbidity. The objective this study was to establish the annual from determine effect hospital volume on outcomes.Hospital Episode Statistics database used for identification patients admitted hospitals within England with between 2001 2012. influence treatment approach upon outcomes analyzed using multivariable analysis control patient age medical comorbidities may outcome.Over...
Claudin-18 (CLDN18) is a highly specific tight junction protein of the gastric mucosa. An isoform CLDN18, Claudin 18.2, has recently emerged as an innovative drug target for metastatic cancer. We investigated immunohistochemical profile p53, p16, E-cadherin, MSH2, MSH6, MLH1, PSM2, HER2, and PDL-1 in large series 523 primary carcinomas (GCs; n = 408) gastro-oesophageal (GECs; 115) 135 matched synchronous nodal metastases. The status HER2 EBER by means chromogenic situ hybridisation (CISH)...
Intestinal metaplasia in the tubular esophagus is recognized precancerous lesion of adenocarcinoma Barrett esophagus. However, it not yet clear whether gastric cardia arises from same premalignant lesion, i.e., intestinal cardia. The purpose this study was to compare adenocarcinomas and at an early stage, when more likely that had been completely overgrown by tumor.The authors compared epidemiologic, clinical, pathologic features stage 42 patients who underwent resection surgery. presence...
OBJECTIVE The loss of myenteric neurons in the lower esophageal sphincter (LES) characterizes achalasia, an motor disorder. Because presence lymphocytic infiltrates suggests immuno-mediated mechanism ongoing at sites disease, we investigated T-cell receptor (TCR) repertoire and ability to recognize human herpes virus type 1 (HSV-1) antigens LES-infiltrating T lymphocytes achalasia patients. METHODS Fifty-nine patients with idiopathic 38 heart-beating cadaveric multiorgan donors (controls)...