A5070567573- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Melanoma and MAPK Pathways
- Cancer Research and Treatments
- Atomic and Subatomic Physics Research
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
- Dark Matter and Cosmic Phenomena
- Lung Cancer Research Studies
- Spectroscopy and Laser Applications
- Colorectal Cancer Screening and Detection
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Atomic and Molecular Physics
- Laser Design and Applications
- Cancer-related molecular mechanisms research
- Cancer and Skin Lesions
- Ovarian cancer diagnosis and treatment
- Hedgehog Signaling Pathway Studies
University of Padua
2017-2024
Istituto Oncologico Veneto
2018-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2023
March of Dimes
2017-2019
Regione del Veneto
2019
University of Parma
1966-1984
Istituto Nazionale per la Fisica della Materia
1975-1977
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
1967
Istituto Nazionale di Fisica Nucleare
1959
PURPOSE More than 50% of patients with stage IV colorectal cancer (metastatic [mCRC]) relapse postresection. The efficacy postoperative systemic treatment is limited in this setting. Thus, these would greatly benefit from the use a reliable prognostic biomarker, such as circulating tumor DNA (ctDNA) to identify minimal or molecular residual disease (MRD). PATIENTS AND METHODS We analyzed cohort 112 mCRC who had undergone metastatic resection curative intent part PREDATOR clinical trial....
Abstract Background Immunotherapy with immune checkpoint inhibitors (ICIs) is highly effective in microsatellite instability–high (MSI-H) metastatic colorectal cancer (mCRC); however, specific predictive biomarkers are lacking. Patients and Methods Data samples from 85 patients MSI-H mCRC treated ICIs were gathered. Tumor infiltrating lymphocytes (TILs) tumor mutational burden (TMB) analyzed an exploratory cohort of “super” responders “clearly” refractory patients; TILs then evaluated the...
Abstract Purpose: BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1–V600E) or dimers 2–codons 597/601), and RAS-dependent with impaired kinase activity 3–codons 594/596). Although clinical, pathologic, molecular features of V600EBRAF-mutated metastatic colorectal cancer (mCRC) well known, limited data available from the two other classes. Experimental Design: Data 117 patients (92 class 1, 12 2, 13 3)-mutated mCRC were collected. A total 540 wt mCRCs...
Claudin-18 (CLDN18) is a highly specific tight junction protein of the gastric mucosa. An isoform CLDN18, Claudin 18.2, has recently emerged as an innovative drug target for metastatic cancer. We investigated immunohistochemical profile p53, p16, E-cadherin, MSH2, MSH6, MLH1, PSM2, HER2, and PDL-1 in large series 523 primary carcinomas (GCs; n = 408) gastro-oesophageal (GECs; 115) 135 matched synchronous nodal metastases. The status HER2 EBER by means chromogenic situ hybridisation (CISH)...
Aims Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPIs) represent a standard of care for the clinical management high-grade serous ovarian cancer (HGSOC). The recognition homologous recombination deficiency (HRD) has emerged as predictive biomarker response first-line PARPIs treatment in patients with HGOSC. On other hand, this test is extremely complex and therefore it often externalised. Regrettably, reliability outsourced HRD testing can be troubled by inconclusive results high...
Abstract Background High-grade gastro-entero-pancreatic neoplasms (HG GEP-NENs) can be stratified according to their morphology and Ki-67 values into three prognostic classes: neuroendocrine tumors grade 3 (NETs G3), carcinomas with < 55% (NECs <55) NECs ≥ ≥55). Methods We analyzed a cohort of 49 HG GEP-NENs by targeted Next-Generation Sequencing (TrueSight Oncology 500), RNA-seq, immunohistochemistry for p53, Rb1, SSTR-2A, PD-L1. Results Frequent genomic alterations affected TP53...
Macrophages have a major influence on inflammation, pathology, and disease the available data suggest that H. pylori persistence can be explained in part by failure of bacterium to killed professional phagocytes. are cells ready kill engulfed pathogen, through oxygen-dependent -independent mechanisms; however, their killing potential further augmented intervention T helper (Th) upon specific recognition human leukocyte antigen (HLA)-II-peptide complexes surface phagocytic cells. As it...
Low‐grade neuroepithelial tumors (LGNT) show a broad histopathological spectrum and may be difficult to classify using current World Health Organization (WHO) criteria. A 57‐year‐old man came medical attention because of headaches. The patient history was otherwise unremarkable. Magnetic resonance imaging (MRI) revealed 2.5 cm lesion, partially cystic, with an increased signal on T2‐weighted imaging, located in the right frontal lobe. underwent craniotomy surgical specimen entirely...
V600EBRAF mutated metastatic colorectal cancer (mCRC) is a subtype (10%) with overall poor prognosis, but the clinical experience suggests great heterogeneity in survival. It still unexplored real distribution of traditional and innovative biomarkers among mCRC which their role improvement prediction survival outcomes.Data tissue specimens from 155 patients treated at eight Italian Units Oncology were collected. Specimens analysed by means immunohistochemistry profiling performed on...
<h3>Background</h3> Analysis of deficiency in DNA mismatch repair (dMMR) is currently considered a standard molecular test all patients with colorectal cancer (CRC) for its implications screening, prognosis and prediction benefit from immune checkpoint inhibitors. While the heterogeneity CRC has been extensively studied recent years, specific data on dMMR status are lacking, clinical consequences unknown. <h3>Case presentation</h3> We report case metastatic (mCRC) patient immunohistochemical...
To test miR-223 upregulation during gastric (intestinal-type) and Barrett esophageal carcinogenesis.
Abstract Purpose Non-neuroendocrine neoplasms of the appendix are a phenotypically heterogeneous group lesions; comprehensive molecular characterization these tumors is still lacking. Methods A total 52 samples taken from 49 patients was evaluated: 18 sessile serrated lesions (SSL; 3 with dysplasia), 2 high-grade tubular adenomas, 1 tubulo-villous adenoma,1 hyperplastic polyp, low-grade appendiceal mucinous (LAMN), (HAMN) and 9 adenocarcinomas. Hotspot mutational profiling RNF43, SMAD4 ,...
Colorectal adenosquamous carcinoma (ASC) is exceedingly rare, comprising less than 0.1% of all colorectal malignancies, and characterized by an aggressive disease course, with a higher metastatic rate worse outcome conventional adenocarcinoma. A comprehensive molecular profile this group neoplasms still lacking. total 22 cases ASCs (with primary lesions 7 metastases matched 4 primaries) were subject to NGS targeting 67 cancer-related genes (VariantPlex solid tumor; Archer). Mismatch repair...
Papillary thyroid carcinoma (PTC) is a miscellaneous disease with variety of histological variants, each its own mutational profile, and clinical prognostic characteristics. Identification microRNA (miRNA) expression profiles represents an important benchmark for understanding the molecular mechanisms underlying biological behavior these unique PTC subtypes in order that they be better characterized. We considered series 35 samples diagnosis either hobnail (17 cases) or classical variant...
miR-224 has recently emerged as a driver oncomiR in sporadic colorectal carcinogenesis, but its pathogenetic role is still controversial. A large phenotypical and molecularly characterized series of preinvasive invasive lesions was investigated for expression by qRT-PCR situ hybridization. The caspase-3 caspase-7 status also assessed correlated to dysregulation. significantly upregulated during the adenoma-carcinoma sequence context inflammatory bowel disease dysplastic lesions, whereas...