A5014886244- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Anorectal Disease Treatments and Outcomes
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- Cancer Treatment and Pharmacology
- Cancer survivorship and care
- Radiomics and Machine Learning in Medical Imaging
- Endometrial and Cervical Cancer Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Esophageal and GI Pathology
- Minimally Invasive Surgical Techniques
- Reconstructive Surgery and Microvascular Techniques
- Chemokine receptors and signaling
- Esophageal Cancer Research and Treatment
Institut de Recherche en Cancérologie de Montpellier
2016-2025
Université de Montpellier
1995-2025
Institut Regional du Cancer de Montpellier
2014-2024
Cancer Institute (WIA)
2013-2024
CEA Valduc
2011-2023
Université Paris Cité
2023
Hôpital Cochin
2023
Assistance Publique – Hôpitaux de Paris
2016-2023
Azienda Ospedaliero-Universitaria Careggi
2023
University of Florence
2023
The European Organisation for Research and Treatment of Cancer conducted a randomized trial investigating the role radiotherapy (RT) after local excision (LE) ductal carcinoma-in-situ (DCIS) breast. We analyzed efficacy RT with 10 years follow-up on both overall risk recurrence (LR) related to clinical, histologic, treatment factors.After complete LE, women DCIS were randomly assigned no further or (50 Gy). One thousand ten mostly (71%) mammographically detected included. median was 10.5...
Purpose A pathologic complete response (pCR; ypT0N0) of a rectal tumor after neoadjuvant radiochemotherapy (RCT) is associated with an excellent prognosis. Several retrospective studies have investigated the effect increasing delay RCT. The aim this study was to evaluate interval between end RCT and surgery on pCR rate. Methods GRECCAR6 phase III, multicenter, randomized, open-label, parallel-group controlled trial. Patients cT3/T4 or Tx N+ tumors mid lower rectum who had received (45 50 Gy...
Purpose Adjuvant radiotherapy (RT) after a local excision (LE) for ductal carcinoma in situ (DCIS) aims at reduction of the incidence recurrence (LR). We analyzed long-term risk on developing LR and its impact survival treatment DCIS. Patients Methods Between 1986 1996, 1,010 women with complete LE DCIS less than 5 cm were randomly assigned to no further (LE group, n = 503) or RT (LE+RT 507). The median follow-up time was 15.8 years. Results Radiotherapy reduced any by 48% (hazard ratio...
BACKGROUND: In rectal surgery, some situations can be critical, such as anterior topography of locally advanced low tumors with a positive predictive radial margin, especially in narrow pelvis men who are obese. Transanal proctectomy is new laparoscopic technique that uses the transanal endoscopic microsurgery device. OBJECTIVE: The aim this study to evaluate technical feasibility patients unfavorable features. DESIGN AND PATIENTS: This single-center, prospective analysis selected cancer...
To assess with a single-blinded, multicenter, randomized trial, the postoperative results in patients undergoing sphincter-saving rectal resection for cancer without preoperative mechanical bowel preparation (MBP).The collective evidence from literature strongly suggests that MBP, before elective colonic surgery, is of no benefit terms morbidity. Very few data and study are available surgery preliminary conclude toward safety MBP.From October 2007 to January 2009, scheduled were receive MBP...
Rectal cancer is a common and serious disease in the Western hemisphere. Optimal treatment of rectal involves multidisciplinary approach, with collaboration required between radiologists, oncologists, surgeons, pathologists to achieve local control decrease rate recurrence. Several studies have been published that show ability accurately stage magnetic resonance (MR) imaging. Moreover, advances preoperative therapies require accurate staging MR imaging select those patients who may benefit...
Abstract Aim Alteration of bowel function after delayed coloanal anastomosis (DCAA) might be a limitation to its utilization. Our aim was assess the long‐term DCAA in large multicentric cohort. Method All patients who underwent interventions at 29 GRECCAR‐affiliated hospitals between 2010 and 2021 were retrospectively included. Low anterior resection syndrome (LARS) score or confection stoma due poor assessed eligible patients. Good defined by preservation continuity with no LARS minor LARS....
Using a prospective, nonrandomized study, the authors evaluated morbidity and functional oncologic results of conservative surgery for cancer lower third rectum after high-dose radiation.Colo-anal anastomosis has made sphincter conservation low rectal carcinoma technically feasible. The limits to currently are rather than technical. Adjuvant radiotherapy proven its benefit in terms regional control, with dose relationship.Since June 1990, 27 patients distal adenocarcinoma were treated by...
Objective: To assess the effect of pelvic drainage after rectal surgery for cancer. Background: Pelvic sepsis is one major complications excision Although many studies have confirmed infectiveness colectomy, there still a controversy surgery. Methods: This multicenter randomized trial with 2 parallel arms (drain vs no drain) was performed between 2011 and 2014. Primary endpoint postoperative within 30 days, including anastomotic leakage, abscess, peritonitis. Secondary endpoints were overall...
Purpose To determine the diagnostic performance of intravoxel incoherent motion (IVIM) parameters and apparent diffusion coefficient (ADC) to assess response combined chemotherapy radiation therapy (CRT) in patients with rectal cancer by using histogram analysis derived from whole-tumor volumes single-section regions interest (ROIs). Materials Methods The institutional review board approved this retrospective study 31 who underwent magnetic resonance (MR) imaging before after CRT, including...
Objective: To identify risk factors for urethral and urologic injuries during transanal total mesorectal excision (taTME) evaluate outcomes. Background: Urethral injury is a rare complication of abdominoperineal resection (APR) that has not been reported abdominal proctectomy. The Low Rectal Cancer Development Program international taTME registry recently 0.8% incidence, but actual incidence mechanisms remain largely unknown. Methods: A retrospective analysis cases complicated by was...
The impact of method anastomosis and minimally invasive surgical technique on clinical outcomes after right hemicolectomy is uncertain. aim the MIRCAST study was to compare intracorporeal extracorporeal (ICA ECA respectively), each using either a laparoscopic approach or robot-assisted surgery during hemicolectomies for benign malignant tumours.This an international, multicentre, prospective, observational, monitored, non-randomized, parallel, four-cohort (laparoscopic ECA; ICA; ICA)....
To determine the rate of nonsentinel lymph node (NSN) involvement at axillary dissection (ALND) and predictive factors this following detection micrometastasis in sentinel nodes (SN).We analyzed 700 observations SN micrometastases with additional ALND characteristics patients, tumors, SN.Involvement was diagnosed 388 times by serial sections (55.4%) standard hemoxylin eosin staining (HES) 312 solely on immunohistochemical analysis (IHC; 44.6%). The accurate size indicated 488 cases: 301...
The detection of autoantibodies in cancer patients has been shown to constitute an excellent tool for early diagnosis. Because breast still lacks diagnostic markers, we investigated novel tumor-associated antigens and related sera from with stage compared autoimmune disease, other cancers, healthy volunteers, using a proteomics-based approach. Among the 26 protein specifically recognized by sera, focused on Heat Shock Protein 60 (HSP60). Using ELISA, frequency directed against this 240...