A5080296829- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Appendicitis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Treatments and Studies
- Diverticular Disease and Complications
- Intraperitoneal and Appendiceal Malignancies
- Hernia repair and management
- COVID-19 and healthcare impacts
- Enhanced Recovery After Surgery
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Abdominal vascular conditions and treatments
- Pelvic and Acetabular Injuries
- Cancer Treatment and Pharmacology
- Gallbladder and Bile Duct Disorders
- Intestinal and Peritoneal Adhesions
- Gastrointestinal Tumor Research and Treatment
- Nutrition and Health in Aging
- Stoma care and complications
- Liver Disease and Transplantation
- Trauma and Emergency Care Studies
Centre Hospitalier Universitaire de Besançon
2016-2025
Université de franche-comté
2019-2025
Inserm
2014-2025
Assistance Publique – Hôpitaux de Paris
2017-2024
Université Paris Cité
2017-2024
Hôpital Cochin
2024
Sorbonne Paris Cité
2024
Institut national de recherche en informatique et en automatique
2024
University of Pittsburgh
2024
Université de Rouen Normandie
2024
Tissue-resident memory (TRM) T cells have emerged as key players in cancer immunosurveillance, and their presence has been linked to a favorable clinical outcome solid patients. Liver metastases exhibit highly immunosuppressive tumor microenvironment, however, the role impact of TRM cell infiltration colorectal remain elusive. The expression several tissue residency activation biomarkers investigated on tumor-infiltrating lymphocytes isolated from 26 patients' liver (CRC metastases) compared...
Abstract Aim Alteration of bowel function after delayed coloanal anastomosis (DCAA) might be a limitation to its utilization. Our aim was assess the long‐term DCAA in large multicentric cohort. Method All patients who underwent interventions at 29 GRECCAR‐affiliated hospitals between 2010 and 2021 were retrospectively included. Low anterior resection syndrome (LARS) score or confection stoma due poor assessed eligible patients. Good defined by preservation continuity with no LARS minor LARS....
Abstract Aim Rectal cancer is a malignant disease requiring multidisciplinary management. In view of the increasing number studies published over past decade, comprehensive update required to draw recommendations for clinical practice mandated by French Research Group Cancer Surgery and National Coloproctology Society. Method Seven questions summarizing treatment rectal were selected. A search evidence in literature from January 2004 December 2015 was performed. drafting committee large...
Abstract Background and Aims Postoperative recurrence is a major concern in Crohn’s disease. The Kono-S anastomosis has been described to reduce the rate of recurrence. However, level evidence for its effectiveness remains low. KoCoRICCO study aimed compare outcomes between conventional two nationwide, prospective cohorts. Methods Adult patients with disease, who underwent ileocolonic resection anastomosis, were prospectively included seven referral centres 2020 2022. Patients side-to-side...
Abstract Aim To compare the learning curve for trans‐anal total mesorectal excision ( TATME ) with laparoscopic TME started by a perineal approach LTME ). Method The first 34 consecutive patients who underwent low rectal cancer were matched (performed same surgeon) gender, body mass index and chemoradiation. Results Thirty‐four undergoing (23 men; 58 ± 14 years) 59 13 years). Intra‐operative complications occurred more frequently during (21%) than (6%), but this difference was not...
To evaluate whether systematic mesh implantation upon primary colostomy creation was effective to prevent PSH.Previous randomized trials on prevention of PSH by placement have shown contradictory results.This a prospective, controlled trial in 18 hospitals France patients aged ≥18 receiving first for an indication other than infection. Participants were blocks random size, stratified center 1:1 ratio with or without synthetic, lightweight monofilament mesh. Patients and outcome assessors...
Abstract Background Surgical resection rates remain high in Crohn’s disease (CD). Reducing postoperative recurrence (POR) is challenging. Besides drug therapy, the surgical anastomosis technique may reduce POR. We aimed to compare endoscopic POR rate after Kono-S vs standard ileocolic anastomosis. Methods The study included all consecutive CD patients operated on for with a between February 2020 and March 2022. These were prospectively followed, colonoscopy was performed 6 12 months surgery....
In advanced pancreatic ductal adenocarcinoma (aPDAC), there is no consensual strategy for second-line chemotherapy (L2). Better discrimination of overall survival (OS) may help clinical decision-making. We aimed to predict OS from the beginning L2 and assess benefit among identified risk groups.Analyses were derived all consecutive aPDAC patients treated at Besancon University Hospital, Besancon, France, between January 2003 December 2013 (n = 462). The association 50 parameters with was...
Abstract Background Laparoscopic lavage was proposed in the 1990s to treat purulent peritonitis patients with perforated acute diverticulitis. Prospective randomized trials had mixed results. The aim of this study determine success rate laparoscopic sepsis control and identify a group that could potentially benefit from treatment. Methods This retrospective multicentre international included consecutive 24 centres who underwent 2005 2015. Results A total 404 were included, 231 whom Hinchey...
Immune checkpoint blockade has proven its efficacy in hypermutated subtypes of metastatic colorectal cancers (mCRC). Immunogenic potential can also be observed with conventional chemotherapies, but this property never been explored thoroughly CRC patients. The therapeutic arsenal includes oxaliplatin, a well-characterized platinum drug already described as immunogenic. Here, we investigated the impact oxaliplatin-based treatment on mCRC immunopeptidome. We demonstrated that...
BACKGROUND: Although elderly patients constitute most of the undergoing surgery for obstructed colon cancer, available data in literature are very limited. OBJECTIVE: The purpose this study was to assess management and outcomes treated cancer. DESIGN: This a multicenter, retrospective cohort study. SETTINGS: Between 2000 2015, 2325 managed an cancer member centers French National Surgical Association were identified. Data collected by each center on voluntary basis after institutional...
Objective: The aim of this study was to define whether rapidly reallocating health care workers not experienced with PP for performing in ICU is feasible and safe. Summary Background Data: In the setting severe acute respiratory distress syndrome (ARDS), use prone supine positioning procedures (PP) has been associated improved oxygenation resulting decreased mortality. Nevertheless, applying time consuming staffs that are at risk mental physical exhaustion, especially constant surge admitted...
BACKGROUND: The optimal elective colectomy in patients with splenic flexure tumor is debated. OBJECTIVE: This study aimed to compare colectomy, left hemicolectomy, and subtotal for perioperative, histological, survival outcomes this setting. DESIGN: a multicenter retrospective cohort study. SETTING: Patients diagnosed nonmetastatic who underwent were included. PATIENTS: Between 2006 2014, 313 consecutive operated on 15 French Research Group of Rectal Cancer Surgery centers. INTERVENTIONS:...
Chronic lung allograft dysfunction (CLAD) substantially limits long-term survival following transplantation. To identify potential targets for CLAD prevention, T cells from explanted lungs and lung-draining lymph nodes, as well diseased nondiseased controls were isolated single-cell RNA sequencing TCR performed. revealed a clonally expanded population of CD8+ tissue-resident memory (TRMs) with high cytotoxic potential, including upregulation KLRK1, encoding the co-receptor NKG2D. These TRMs...