A5022300505- Data-Driven Disease Surveillance
- Spondyloarthritis Studies and Treatments
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Hemodynamic Monitoring and Therapy
- Pregnancy and preeclampsia studies
- Spatial and Panel Data Analysis
- Studies on Chitinases and Chitosanases
- Nausea and vomiting management
- Radiation Dose and Imaging
- Rheumatoid Arthritis Research and Therapies
- Pelvic floor disorders treatments
- Anesthesia and Pain Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Multiple Sclerosis Research Studies
- Advanced X-ray and CT Imaging
- Indoor Air Quality and Microbial Exposure
- Scoliosis diagnosis and treatment
- Hepatitis C virus research
- Diagnosis and Treatment of Venous Diseases
- Pressure Ulcer Prevention and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Craniofacial Disorders and Treatments
- Psoriasis: Treatment and Pathogenesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Université de Montpellier
2008-2025
Université de Nîmes
2015-2025
Centre National de la Recherche Scientifique
2022-2024
Inserm
2022-2024
Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic
2024
Centre Hospitalier Universitaire de Montpellier
2011-2024
Centre Hospitalier Universitaire de Nîmes
2014-2024
Southwestern Medical Center
2022
Centre Hospitalier de Perpignan
2022
Hôpital Gui de Chauliac
2022
To confirm the rapid onset anti-suicidal benefits of ketamine in short term and at six weeks, overall according to diagnostic group.Prospective, double blind, superiority, randomised placebo controlled trial.Seven French teaching hospitals between 13 April 2015 12 March 2019.Aged 18 or older with current suicidal ideation, admitted hospital voluntarily. Exclusion criteria included a history schizophrenia other psychotic disorders, substance dependence, contraindications for ketamine.156...
Background: Despite sensitivity of MRI to diagnose multiple sclerosis (MS), prognostic biomarkers are still needed for optimized treatment. Objective: The objective this paper is identify cerebrospinal fluid (CSF) diagnostic MS using quantitative proteomics and analyze their expression at different disease stages. Methods: We conducted differential analysis the CSF proteome from control relapsing–remitting (RRMS) patients followed by verification ELISA candidate in serum control, clinically...
Objective To estimate sacroiliac joint radiographic (X-SIJ) progression in patients with axial spondyloarthritis (axSpA) and to evaluate the effects of inflammation on MRI (MRI-SIJ) X-SIJ progression. Methods MRI-SIJ at baseline after 2 5 years recent onset axSpA from DESIR cohort were scored by three central readers. Progression was defined as (1) shift non-radiographic (nr) (r) sacroiliitis (by modified New York (mNY) criteria) or alternative criteria, (2) a change least one grade (3) but...
Background and purpose The prognostic value of serum neurofilament light chain ( sNfL ), a biomarker neurodegeneration, compared to other factors amyotrophic lateral sclerosis ALS ) at the time diagnosis, remains unclear. Methods Sera from patients were prospectively collected first diagnostic visit in our centre. levels determined by single molecule array 207 21 healthy controls. was with that known clinical using Cox regression model multivariate analysis. Results Serum higher than...
Objective To evaluate the rate of radiographic structural progression in sacroiliac (SI) joints patients with or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing such progression, over 2 years. Methods Patients recent‐onset SpA (from Devenir des Spondyloarthropathies Indifferérenciées Récentes cohort) were assigned a SI joint score according modified New York criteria. Demographic characteristics, smoking status, HLA–B27 positivity, inflammation on...
Background: NETosis occurs in the context of infection or inflammation and results expulsion decondensed DNA filaments called NETs (Neutrophil Extracellular Traps) into extracellular environment. activates coagulation contributes to thrombotic risk inflammatory diseases. To date, two mechanisms have been identified: suicidal NETosis, which neutrophils die after expelling filaments; vital appears without altering membrane. Human pregnancy is associated with a mild pro-inflammatory state,...
The prevalence of overweight and obesity reached 19.7% in 12-year-old French children the year 2005. Recently, nationwide programs have been broadly implemented France to reduce overconsumption sugars, salt fat. aims this study were assess distribution body mass index (BMI) D<sub>3</sub><sub>+</sub><sub>4</sub>MFT a sample children, compare several regression models order analyze association between these two indices. A cross-sectional was conducted...
Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment response FC at end infusion or 20 min later could affect results FC.This a prospective, observational, multicenter including all ICU patients septic shock requiring 500 mL crystalloids over 10 min. responsiveness was defined as > 15% increase stroke volume (SV) assessed by velocity-time integral (VTI) measurements baseline (T0),...
To evaluate whether systematic mesh implantation upon primary colostomy creation was effective to prevent PSH.Previous randomized trials on prevention of PSH by placement have shown contradictory results.This a prospective, controlled trial in 18 hospitals France patients aged ≥18 receiving first for an indication other than infection. Participants were blocks random size, stratified center 1:1 ratio with or without synthetic, lightweight monofilament mesh. Patients and outcome assessors...
Background/Objectives: Vascular aging is associated with increased arterial stiffness and changes in the wall structure, leading to a loss of elasticity. Silicon abundant arteries plays key role synthesis stabilization elastin fibers. In animal models accelerated cardiovascular aging, specific nutritional supplement based on silicon-enriched spirulina (SpSi) has been shown have beneficial effects vascular function. The present study, designed as randomized, double-blind, placebo-controlled...
Importance Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and associated with the of disease activity, but data on benefits supplementation are conflicting. Objective To evaluate efficacy high-dose cholecalciferol as monotherapy in reducing activity patients clinically isolated syndrome (CIS) typical MS. Design, Setting, Participants The D-Lay MS trial was parallel, double-blind, randomized placebo-controlled clinical 36 centers France. Patients were enrolled from July...
AbstractOBJECTIVES: The study aimed to evaluate cognitive function and emotional reactivity in 18 patients with ALS, compared to19 matched controls, assess their evolution over a 12‐month period.METHODS: ALS 19 controls were included, assessed at inclusion, six months twelve later. Depression was evaluated the Geriatric Scale, Folstein Mini Mental State. A battery of psychometric tests (Wisconsin Card Sorting Test (WCST), numerical Empan test, Trail‐making Boston Naming Test, 15‐word Rey...
Exposure to indoor chemical air pollutants expected be potentially involved in allergic respiratory diseases infants is poorly documented. A specific environmental investigation included a birth cohort study was carried out first assess airborne aldehyde levels, using passive devices and their variability within 1 year (1, 6, 9 12 months) the bedroom of 196 Paris infants, second, identify predictors for concentrations interviewer administered questionnaires about housing factors. Comfort...
To compare the performance of anticitrullinated peptides/protein antibodies (ACPA) detected by three immunoassays in French ESPOIR cohort patients with early rheumatoid arthritis (RA) and undifferentiated (UA) to study relationship between ACPA disease activity. A diagnosis RA (1987 American College Rheumatology (ACR) criteria) was established at baseline 497 after a 2-year follow-up 592 patients. At baseline, citrullinated fibrinogen (AhFibA), antimutated vimentin (anti-MCV) anticyclic...
Bacterial species and their role in delaying the healing of pressure ulcers (PU) spinal cord injury (SCI) patients have not been well described. This pilot study aimed to characterise evolution cutaneous microbiota PU SCI cohort. Twenty-four with from a French neurological rehabilitation centre were prospectively included. tissue biopsies performed at baseline (D0) 28 days (D28) analysed using 16S rRNA gene-based sequencing analysis V3-V4 region. At D0, if overall relative abundance genus...
<h3>Background and Objectives</h3> To evaluate the predictive value of serum neurofilament light chain (sNfL) CSF NfL (cNfL) in patients with radiologically isolated syndrome (RIS) for evidence disease activity (EDA) clinical conversion (CC). <h3>Methods</h3> sNfL cNfL were measured at RIS diagnosis by single-molecule array (Simoa). The risk EDA CC according to was evaluated using Kaplan-Meier analysis multivariate Cox regression models including age, spinal cord (SC) or infratentorial...
To investigate the accuracy of prenatal axial three-dimensional (3D) ultrasound in predicting absence or presence cleft palate lip.Between March 2005 and January 2009, there were 81 cases with a two-dimensional (2D) screening diagnosis unilateral bilateral lip at 22-25 weeks gestation referred to our tertiary care center. Of these, 79 fetuses included this prospective study two excluded. Axial 3D imaging fetal was performed diagnoses compared clinical findings delivery. The frequencies...
Objective. To determine the prevalence of anterior chest wall (ACW) pain in patients with recent inflammatory back (IBP) suggestive spondyloarthritis (SpA), and to investigate influence ACW on overall features these patients. Methods. The DESIR cohort is a prospective, multicenter French early IBP SpA, including 708 (mean age 33.8 yrs, 53.8% females, 57.3% HLA-B27-positive). was defined by at least 1 episode attributed SpA rheumatologist, after ruling out other causes pain. Data baseline...
Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict clinically (CIS) RRMS. Objective: To evaluate prognostic value CSF CHI3L1 in RIS patients for Methods: We compared concentrations RIS, CIS, RRMS symptomatic controls (SCs). analysed influence epidemiological,...
The aim of this study was to identify novel biomarkers for multiple sclerosis (MS) diagnosis and prognosis, addressing the critical need specific prognostically valuable markers in field.