A5071884339- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Spine and Intervertebral Disc Pathology
- Musculoskeletal synovial abnormalities and treatments
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Surgery and Rehabilitation
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Medical Imaging and Analysis
- Scoliosis diagnosis and treatment
- Shoulder Injury and Treatment
- Orthopedic Infections and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Osteomyelitis and Bone Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Shoulder and Clavicle Injuries
- Viral Infections and Immunology Research
- Elbow and Forearm Trauma Treatment
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Bone fractures and treatments
- Advanced MRI Techniques and Applications
- Tendon Structure and Treatment
Leiden University Medical Center
2016-2025
Leiden University
2014-2024
Charité - Universitätsmedizin Berlin
2024
Humboldt-Universität zu Berlin
2024
Freie Universität Berlin
2024
Sheba Medical Center
2024
Tel Aviv University
2024
University College London Hospitals NHS Foundation Trust
2024
National Institute for Health Research
2024
Diakonhjemmet Hospital
2015
Objectives The Assessment of SpondyloArthritis international Society (ASAS) MRI working group (WG) was convened to generate a consensus update on standardised definitions for lesions in the sacroiliac joint (SIJ) patients with spondyloarthritis (SpA), and conduct preliminary validation. Methods literature pertaining these lesion discussed at three meetings group. 25 investigators (20 rheumatologists, 5 radiologists) determined which should be retained or required revision, new definition....
Calcific tendinitis of the rotator cuff (RCCT) is frequently diagnosed in patients with shoulder pain, but there no consensus on its treatment.To compare 2 regularly applied RCCT treatments: ultrasound (US)-guided needling and lavage (barbotage) combined a US-guided corticosteroid injection subacromial bursa (subacromial [SAI]) (group 1) versus an isolated SAI 2).Randomized controlled trial; Level evidence, 1.Patients were randomly assigned to groups. Shoulder function was assessed before...
<h3>Introduction</h3> Patients with clinically suspect arthralgia (CSA) have, according to their rheumatologists, an increased risk of rheumatoid arthritis (RA), but actual outcome is unexplored. This longitudinal study investigated (1) progression from CSA detectable and (2) associations clinical factors, serological factors (among which are anticitrullinated peptide antibodies (ACPAs)) MRI-detected subclinical inflammation development. <h3>Methods</h3> 150 patients were followed for ≥6...
<h3>Objective</h3> To compare the original Berlin algorithm for diagnosing axial Spondyloarthritis (axSpA) with two modifications in SPondyloArthritis Caught Early (SPACE)-cohort and Assessment of SpondyloArthritis international Society (ASAS) axSpA criteria validation (ASAS)-cohort. <h3>Methods</h3> Patients SPACE-cohort (back pain ≥3 months, ≤2 years, onset <45 years) ASAS-cohort (undiagnosed chronic back pain) were diagnosed according to three algorithms: (inflammatory (IBP)...
To investigate the degree of agreement between local rheumatologists/radiologists and central trained readers (external standard) on presence/absence sacroiliitis radiographs sacroiliac (SI) joints.Patients with inflammatory back pain (duration ≥3 months but <3 years) suggestive axial spondyloarthritis (SpA) were included in Devenir des Spondylarthropathies Indifferérenciées Récentes (DESIR) cohort. Baseline SI joints interpreted by 2 (modified New York criteria); cases disagreement...
To analyse whether MRI of upper and lower extremity muscles in a large patient group with sporadic IBM (sIBM) is additional value the diagnostic work-up sIBM.Thirty-two sIBM patients were included. Magnetic resonance (MR) parameters evaluated 68 muscle atrophy, fatty infiltration inflammation. These findings correlated disease duration, weakness serum creatine kinase (sCK) levels.Fatty was far more common than Muscles most frequently infiltrated fat flexor digitorum profundus (FDP), anterior...
Purpose: To compare different lipid multipeak spectral models to the single‐peak model in Dixon‐based fat‐water separation and evaluate differences between visually scored magnetic resonance (MR) images quantitatively assessed fat fractions muscle of Duchenne muscular dystrophy patients. Materials Methods: T1‐weighted 3‐point Dixon imaging upper lower leg was performed 13 patients six healthy controls. Three‐, four‐, five‐peak spectrum were compared a each other. by two radiologists...
To investigate the association of ultrasound (US) features-grey scale (GS) synovitis, synovial thickening, effusion and power Doppler signal (PDS)-with symptoms in hand osteoarthritis (HOA).Fifty-five consecutive patients (mean age 62 years, 87% women) with HOA, fulfilling American College Rheumatology criteria, were assessed for pain upon palpation filled Australian/Canadian Osteoarthritis Index (AUSCAN) scores, visual analogue Short Form-36 (SF-36). US was performed all...
Background The phase of arthralgia is the earliest moment to clinically recognize patients who may develop Rheumatoid Arthritis (RA). Previous imaging studies in have shown that inflammation precedes RA development. It unknown which symptoms/characteristics relate subclinical joint as measured by MRI. Among all with arthralgia, those suspect (CSA) are suspected progress arthritis according clinical judgement their rheumatologists. We determined CSA had on Methods 102 and without were...
<h3>Objectives</h3> To investigate the extent and performance of MRI lesions in sacroiliac joint (MRI-SI) spine (MRI-spine) patients with suspected axial spondyloarthritis (axSpA). <h3>Methods</h3> MRI-SI/spine chronic back pain (onset <45 years) SPondyloArthritis Caught Early (SPACE) cohort were scored by two well-trained readers for inflammation, fatty lesions, erosions, sclerosis/ankylosis syndesmophytes. performances tested against Assessment Spondyloarthritis international Society...
The use of magnetic resonance imaging (MRI)-detected inflammation and joint damage in the diagnosis rheumatoid arthritis is recommended by a European League Against Rheumatism task force. This recommendation based on sensitivity MRI not specificity. Knowledge prevalence MRI-detected features symptom-free persons, however, pivotal when considering for diagnostic purposes.From November 2013 to December 2014, 196 persons different ages were recruited from general population. Inclusion criteria...
Objectives To compare the CT Syndesmophyte Score (CTSS) for low-dose (ldCT) with modified Stoke Ankylosing Spondylitis Spine (mSASSS) conventional radiographs (CR) in patients ankylosing spondylitis (AS). Methods Patients AS Sensitive Imaging cohort had lateral cervical and lumbar spine CR whole ldCT at baseline 2 years. images were scored by two readers, paired patient, blinded to time order, per imaging modality. For total score analysis, we used average scores of readers corner on or...
A range of sacroiliac joint (SIJ) MRI protocols are used in clinical practice but not all were specifically designed for diagnostic ascertainment. This can be confusing and no standard SIJ protocol is currently accepted worldwide.
Objectives. To investigate the additional value of T1 fat-saturated after gadolinium (T1/Gd) compared with and short tau inversion recovery (STIR) sequence in detecting active lesions SI joints typical axial SpA (axSpA) a prospective cohort study, SpondyloArthritis Caught Early (SPACE) cohort, to assess its influence on final MRI diagnosis joint (MRI-SIJ) based Assessment Spondyloarthritis International Society (ASAS) definition sacroiliitis. Methods. Patients SPACE received baseline 3-month...
To study the development of inflammatory features and it's relation to structural damage over a 2.3-year period in patients with hand osteoarthritis (HOA).Synovial thickening, effusion power Doppler signal (PDS) distal interphalangeal (DIP), proximal (PIP), 1st carpometacarpal (CMC) metacarpal phalangeal (MCP) (IP) joints were assessed using ultrasonography 56 consecutive HOA (mean age 61.2 years, 85.7% female) fulfilling American College Rheumatology (ACR) classification criteria, at...
In 2003, the Nobel Prize for Medicine was awarded contribution to invention of MRI, reflecting incredible value MRI medicine. Since enormous technical advancements have been made in acquiring MR images. However, has a complicated, accident-prone dark side; images are not calibrated and respective dependent on all kinds subjective choices settings machine, acquisition technique parameters, reconstruction techniques, data transmission, filtering postprocessing techniques. The bright side is...
Objective To compare inflammation as assessed by ultrasound between patients with the subset erosive hand osteoarthritis (EOA) versus non-EOA. Methods Consecutive (HOA) (fulfilling ACR criteria) were included. Eighteen interphalangeal joints scored on radiographs using Verbruggen–Veys anatomical phase score; E and R phases defined erosive. Patients assigned to EOA when at least one joint was Effusion, synovial thickening power Doppler signal (PDS) a 4-point scale. Generalised estimated...
Investigating changes in patient classification (ASAS (Assessment of SpondyloArthritis international Society) axSpA criteria) based on evaluation images the sacro-iliac joints (MRI-SI and X-SI) by local central readers.The DESIR cohort included patients with inflammatory back pain (IBP; ≥3 months, but <3 years), suggestive axSpA. Local radiologists/rheumatologists (local-reading) two readers (central-reading) evaluated baseline images. Agreement regarding positive MRI (pos-MRI) between...
Magnetic resonance imaging (MRI) is a sensitive method to detect inflammation in rheumatoid arthritis (RA), visualizing synovitis, bone marrow edema, and tenosynovitis. The prevalence of MRI-detected tenosynovitis its diagnostic value early are unclear. This study was undertaken identify the frequency MRI-detectable at metacarpophalangeal (MCP) wrist joints association these with RA severity RA.A total 178 patients underwent unilateral 1.5T extremity MRI baseline. MCP were scored using...
Objective To evaluate the rate of radiographic structural progression in sacroiliac (SI) joints patients with or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing such progression, over 2 years. Methods Patients recent‐onset SpA (from Devenir des Spondyloarthropathies Indifferérenciées Récentes cohort) were assigned a SI joint score according modified New York criteria. Demographic characteristics, smoking status, HLA–B27 positivity, inflammation on...