A5050983857- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Shoulder and Clavicle Injuries
- Pediatric Hepatobiliary Diseases and Treatments
- Shoulder Injury and Treatment
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Liver physiology and pathology
- Surgical Simulation and Training
- Streptococcal Infections and Treatments
- Pregnancy and Medication Impact
- Simulation-Based Education in Healthcare
- Biliary and Gastrointestinal Fistulas
- Innovations in Medical Education
- Renal Transplantation Outcomes and Treatments
- Clinical Nutrition and Gastroenterology
- Musculoskeletal synovial abnormalities and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Genomics, phytochemicals, and oxidative stress
- Liver Diseases and Immunity
- Reproductive System and Pregnancy
Erasmus MC Transplant Institute
2024
Erasmus MC
2017-2024
Hôpital Paul-Brousse
2017-2018
Leiden University Medical Center
2013-2016
Medisch Centrum Haaglanden
2015
Calcific tendinitis of the rotator cuff (RCCT) is frequently diagnosed in patients with shoulder pain, but there no consensus on its treatment.To compare 2 regularly applied RCCT treatments: ultrasound (US)-guided needling and lavage (barbotage) combined a US-guided corticosteroid injection subacromial bursa (subacromial [SAI]) (group 1) versus an isolated SAI 2).Randomized controlled trial; Level evidence, 1.Patients were randomly assigned to groups. Shoulder function was assessed before...
Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is widely considered as a terminal condition. Therefore, the role surgery uncertain in this case. The purpose study was to identify prognostic factors survival post‐LT HCC recurrence and evaluate impact setting. All patients transplanted for between 1991 2013 single institution who further developed were included study. Univariate multivariate analyses performed affecting postrecurrence survival. Of 493 HCC, total...
Knowledge on the epidemiology and long-term course of rotator cuff calcific tendinitis (RCCT) is scarce. We assessed demographics, radiological characteristics, their association with outcomes in a large patient group. Baseline characteristics treatment were recorded 342 patients. Interobserver agreement measures was analyzed. Long-term outcome evaluated questionnaires (WORC, DASH). The baseline assessed. Mean age 49.0 (SD = 10.0), 59.5 % female. dominant arm affected 66.0 %, 21.3 had...
Early allograft dysfunction (EAD) after liver transplantation (LT) is associated with inferior graft survival. EAD more prevalent in grafts from donation circulatory death (DCD). However, accurate prediction of function remains difficult because the lack specific biomarkers. Recent experimental and clinical studies highlight potential hepatocyte-derived microRNAs (miRNAs) as sensitive, stable, biomarkers injury. The aim this study was to determine whether miRNAs preservation fluid are...
Cell-free microRNAs (miRs) have emerged as early and sensitive biomarkers for tissue injury function. This study aimed to investigate whether the release of hepatocyte-derived (HDmiRs) cholangiocyte-derived miRs (CDmiRs) correlates with hepato-cholangiocellular function during oxygenated, normothermic machine perfusion (NMP) human liver grafts.Donor livers (n = 12), declined transplantation, were subjected oxygenated NMP (6 hours) after a period static cold storage (median 544 minutes (IQR...
Sulforaphane (SFN) has anti-inflammatory properties, and is found in broccoli sprouts. Studies suggest that it protects against disease due to its activity. The impact of SFN on healthy people undergoing a surgical procedure not been investigated. To explore the effect living kidney donors postoperative inflammatory response recovery. We performed double-blind randomised controlled trial where followed SFN-enriched (8 mg) preoperative diet. A total 42 were included, there no significant...
Many factors may compromise the functional recovery of a harvested potential liver for engraftment. Normothermic machine perfusion (NMP) can revive hepatic metabolism ex vivo enabling subsequent transplantation. In this study, we evaluated 11 discarded livers' function utilizing NMP.Eleven consecutive livers underwent NMP 6 hours. Liver was defined by lactate levels ≤3 mmol/L and continuous bile production.Ten perfused were fatty. The median percentage macrosteatosis (MaS) microsteatosis...
Abstract Background Medical students are expected to translate the theoretical knowledge gained during their study practical clerkships. A surgical educational platform with standardized videos may be solution. However, effects of a structured online video-based in addition standard curriculum on students’ self-reported and tested clerkship must assessed. Methods Fourth-year medical ( n = 178) participated 6-week course training followed by 10-week in-hospital Erasmus University Center...
Primary sclerosing cholangitis (PSC) is a chronic progressive pathological process, related to inflammatory bowel disease and subsequent bacterial translocation. Liver transplantation (LT) the only curative therapy, but outcomes are compromised by recurrence of PSC (rPSC). The aim study was investigate potential link between intestinal bacteremia, fucosyltransferase-2 (FUT2), rPSC after LT.LT recipients with (n = 81) or without 271) were analyzed for clinical positive blood cultures. A...
An 82-year-old woman without any previous medical history arrived in the emergency department with severe pain entire abdomen since 5 h. Blood tests showed, apart from a CRP of 28 mg/l, no abnormalities. We decided to perform an abdominal ultrasound, which showed easily compressible gallbladder, containing small, mobile gallstone and free fluid abdomen. During ultrasound-guided punction this fluid, bile is aspirated. performed laparoscopy confirmed large amount intraperitoneal bile. Upon...