A5028102614- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
- Spine and Intervertebral Disc Pathology
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Hip disorders and treatments
- Pregnancy-related medical research
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Systemic Lupus Erythematosus Research
- Orthopedic Infections and Treatments
- Infrared Thermography in Medicine
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Orthopaedic implants and arthroplasty
- Asthma and respiratory diseases
- Advanced Neuroimaging Techniques and Applications
- Inflammasome and immune disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Scoliosis diagnosis and treatment
- Osteomyelitis and Bone Disorders Research
- Biosimilars and Bioanalytical Methods
Rigshospitalet
2016-2025
University of Copenhagen
2016-2025
Glostrup Hospital
2016-2025
Center for Rheumatology
2014-2025
Copenhagen University Hospital
2010-2024
Gentofte Hospital
2009-2021
University Medical Center Groningen
2021
University of Alberta
2009-2019
Sheba Medical Center
2014-2019
Assistance Publique – Hôpitaux de Paris
2019
Abstract Objective To determine whether a vertebral corner that demonstrates an active inflammatory lesion (CIL) on magnetic resonance imaging (MRI) in patients with ankylosing spondylitis (AS) is more likely to evolve into de novo syndesmophyte visible plain radiography than no inflammation MRI. Methods MRI scans and radiographs were obtained for 29 recruited randomized placebo‐controlled trials of anti–tumor necrosis factor α (anti‐TNFα) therapy. was conducted at baseline, 12 or 24 weeks...
Abstract Objective To systematically assess the diagnostic utility of magnetic resonance imaging (MRI) to differentiate patients with spondylarthritis (SpA) from nonspecific back pain and healthy volunteers, using a standardized evaluation MR images sacroiliac joints. Methods Five readers blinded diagnoses independently assessed MRI scans (T1‐weighted STIR sequences) joints obtained 187 subjects: 75 ankylosing spondylitis (AS; symptom duration ≤10 years), 27 preradiographic inflammatory...
Objectives The Assessment of SpondyloArthritis international Society (ASAS) MRI working group (WG) was convened to generate a consensus update on standardised definitions for lesions in the sacroiliac joint (SIJ) patients with spondyloarthritis (SpA), and conduct preliminary validation. Methods literature pertaining these lesion discussed at three meetings group. 25 investigators (20 rheumatologists, 5 radiologists) determined which should be retained or required revision, new definition....
Ultrasound (US)-guided interstitial hyperthermia performed with the neodymium yttrium aluminum garnet laser a diffuser tip involves placement of fiber in solid tissue followed by irradiation from within center tumor to be treated. The authors previously described development US-guided technique that permits simultaneous and temperature measurements, real-time US monitoring. With use dedicated modification bare fiber, it has proved possible produce spherical coagulations diameter comparable...
OBJECTIVE:: To systematically assess the diagnostic utility of MRI to differentiate spondyloarthritis (SpA) patients from with non-specific back pain (NSBP) and healthy volunteers using a standardized evaluation MR images sacroiliac joints (SIJ). METHODS:: Five readers blinded patient diagnosis independently assessed scans (T1-weighted STIR sequences) SIJ 187 subjects: 75 AS (symptom duration </=10 years); 27 pre-radiographic inflammatory (IBP) (mean symptom 29 months); 26 NSBP 59 controls...
OBJECTIVES: To evaluate the rate of postoperative complications, length stay, and 1‐year mortality before after introduction a comprehensive multidisciplinary fast‐track treatment care program for hip fracture patients (the optimized program). DESIGN: Retrospective chart review with historical control. SETTING: Orthopedic ward (110 beds) at university hospital (700 beds). PARTICIPANTS: Five hundred thirty‐five consecutive aged 40 older (94%≥60) hospitalized between January 1, 2003, March 31,...
Objective. There is an unmet need for reliable assessment of structural progression in the sacroiliac joints (SIJ) patients with spondyloarthritis (SpA), but radiography unreliable and lacks responsiveness. We aimed to develop validate a new scoring method lesions based on magnetic resonance imaging (MRI), Spondyloarthritis Research Consortium Canada (SPARCC) SIJ Structural Score (SSS). Methods. The SSS T1-weighted spin echo MRI, validated lesion definitions, slice selection according...
Fat metaplasia in bone marrow on T1-weighted magnetic resonance imaging (MRI) scans may develop after resolution of inflammation patients with ankylosing spondylitis (AS) and predict new formation the spine. Similar tissue, termed backfill, also fill areas excavated sacroiliac (SI) joints reflect tissue repair at sites erosions. The purpose this study was to test our hypothesis that SI joint ankylosis develops following erosions characterized by fat is a key intermediary step pathway.We used...
<h3>Objectives</h3> To investigate the ability of whole-body MRI (WBMRI) to detect axial and peripheral enthesitis in patients with psoriatic arthritis (PsA) spondyloarthritis (axSpA), healthy subjects (HS). Furthermore, develop indices based on WBMRI validate these by use clinical measures disease activity. <h3>Methods</h3> Prospective cross-sectional study PsA (n=18) axSpA moderate high activity, HS (n=12). Enthesitis at 35 individual sites located upper lower limbs, chest pelvis were...
Objective To assess the incremental diagnostic value of spine MRI evaluated separately from and combined with sacroiliac joint (SIJ) in non-radiographic axial spondyloarthritis (nr-axSpA) compared SIJ alone. Methods The study sample comprised two independent cohorts A/B 130 consecutive patients aged ≤50 years back pain, newly referred to university clinics, 20 healthy controls. Patients were classified according clinical examination pelvic radiographs as having nr-axSpA (n=50), ankylosing...
<h3>Objective</h3> To determine candidate lesion-based criteria for a positive sacroiliac joint (SIJ) MRI based on bone marrow oedema (BMO) and/or erosion in non-radiographic axial spondyloarthritis (nr-axSpA); to compare the performance of with global evaluation by expert readers. <h3>Methods</h3> Two independent cohorts A/B 69/88 consecutive patients back pain aged ≤50 years, median symptom duration 1.3/10.0 were referred suspected SpA (A) or acute anterior uveitis plus (B). Patients...
To determine quantitative SI joint MRI lesion cut-offs that optimally define a positive for inflammatory and structural lesions typical of axial SpA (axSpA) predict clinical diagnosis.The Assessment SpondyloArthritis international Society (ASAS) group assessed MRIs from the ASAS Classification Cohort in two reading exercises where (A) 169 cases 7 central readers; (B) 107 8 readers. We calculated sensitivity/specificity number quadrants or slices with bone marrow oedema (BME), erosion, fat...
Spinal MRI is used to visualise lesions associated with axial spondyloarthritis (axSpA). The ASAS working group (WG) updated and validated the definitions for inflammatory structural spinal in context of axSpA.
To investigate the ability of MRI-based synthetic CT (sCT), low-dose (ldCT) and radiography to detect spinal new bone formation (NBF) in patients with axial spondyloarthritis (axSpA).
Abstract Objective To compare the diagnostic utility of T1‐weighted and STIR magnetic resonance imaging (MRI) sequences in early spondylarthritis (SpA) using a standardized approach to evaluation sacroiliac (SI) joints, test whether systematic calibration readers directed at recognition abnormalities on MRI would enhance utility. Methods Six independently assessed scans SI joints from 187 subjects: 75 ankylosing spondylitis (AS) 27 preradiographic inflammatory back pain (IBP) patients, 26...
OBJECTIVE--To see whether small daily doses of prednisolone have any adverse effect on short term linear growth in children with mild asthma. DESIGN--Double blind, random order crossover trial two dosages prednisolone. During run and washout periods patients were given placebo. All treatment weeks9 duration. SETTING--Outpatient clinic referrals a secondary referral centre. PATIENTS--14 Children (10 boys) aged 7-11 years normal velocity during the previous year, no signs puberty, history...
To investigate construct validity and responsiveness of the novel ankylosing spondylitis (AS) disease activity score (ASDAS) in patients with spondyloarthritis (SpA).In a 46-week prospective longitudinal multicentre study 60 SpA (80% men, median age 40 years (range 21-62)) treated tumour necrosis factor alpha (TNFalpha) inhibitors (infliximab, n=41; etanercept, n=13; adalimumab, n=6), ASDAS, conventional clinical measures treatment response Berlin MRI sacroiliac joint (SIJ) lumbar spine...
<h3>Objectives</h3> To investigate the relation between ankylosing spondylitis disease activity score (ASDAS), Bath index (BASDAI) and treatment response biomarkers of inflammation (C-reactive protein (CRP), interleukin-6 (IL-6), YKL-40), angiogenesis (vascular endothelial growth factor (VEGF)), cartilage (C-terminal crosslinking telopeptide type II collagen (CTX-II), matrix metalloproteinase-3 (MMP-3), total aggrecan, oligomeric protein) bone I collagen, osteocalcin) turnover in 60 patients...
Objective. To test the hypothesis that in patients with ankylosing spondylitis (AS) a vertebral corner inflammatory lesion (CIL) visible on magnetic resonance imaging (MRI) completely resolves following treatment anti-tumor necrosis factor-α (TNF-α) agents is more likely to develop into de novo syndesmophyte radiograph as compared no CIL. Methods. Fifty AS, who had MRI at baseline and followup (mean 19.2 months), spinal radiography after 2 years, were followed prospectively. A persistent CIL...
Erosions of the sacroiliac joints (SIJ) on pelvic radiographs patients with ankylosing spondylitis (AS) are an important feature modified New York classification criteria. However, radiographic SIJ erosions often difficult to identify. Recent studies have shown that can be detected also magnetic resonance imaging (MRI) early in disease course before they seen radiography. The goals this study were assess reproducibility erosion and related features, namely, extended (EE) backfill (BF)...
To investigate the relationship of circulating biomarkers inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and YKL-40), angiogenesis (vascular endothelial growth factor), cartilage turnover (C-terminal crosslinking telopeptide type II collagen [CTX-II], total aggrecan, matrix metalloproteinase 3 [MMP-3], oligomeric [COMP]), bone (CTX-I osteocalcin) to on magnetic resonance imaging (MRI) radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor...