A5058359408- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods and Inference
- Advanced Causal Inference Techniques
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Statistical Methods and Bayesian Inference
- Spine and Intervertebral Disc Pathology
- Bayesian Methods and Mixture Models
- Lymphoma Diagnosis and Treatment
- Hip disorders and treatments
- Rheumatoid Arthritis Research and Therapies
- Cancer Genomics and Diagnostics
- Advanced Statistical Methods and Models
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Optimal Experimental Design Methods
- Shoulder and Clavicle Injuries
- Computational Drug Discovery Methods
- Shoulder Injury and Treatment
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal pain and rehabilitation
- Meta-analysis and systematic reviews
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
Roche (Switzerland)
2015-2024
La Roche College
2024
Universität Ulm
2024
Roche (Estonia)
2020
Biostatistical Consulting (United States)
2013-2019
University of Zurich
2007-2014
University of Göttingen
2009-2014
University of Bern
2005-2014
Institute of Social and Preventive Medicine
2007-2013
University Hospital of Bern
2005-2013
Rituximab-based immunochemotherapy has improved outcomes in patients with follicular lymphoma. Obinutuzumab is a glycoengineered type II anti-CD20 monoclonal antibody. We compared rituximab-based chemotherapy obinutuzumab-based previously untreated advanced-stage
Objective Low‐grade bone marrow edema ( BME ) has been reported in the sacroiliac SI joints of 25% healthy individuals and patients with nonspecific mechanical back pain, thus challenging specificity predictive value magnetic resonance imaging MRI for discrimination early spondyloarthritis (SpA). It is unknown whether stress injury competition sports may trigger . This study sought to explore frequency anatomic distribution joint lesions recreational elite athletes. Methods After pretest...
Purpose To determine whether the application of two courses cisplatin simultaneously with hyperfractionated radiotherapy improves outcome in locally advanced and/or node-positive nonmetastatic carcinomas head and neck, compared alone. Patients Methods From July 1994 to 2000, 224 patients squamous cell neck (excluding nasopharynx paranasal sinus) were randomly assigned (median dose, 74.4 Gy; 1.2 Gy twice daily) or same combined cycles concomitant (20 mg/m 2 on 5 days weeks 1 5). The primary...
This randomized phase II trial evaluated two docetaxel-based regimens to see which would be most promising according overall response rate (ORR) for comparison in a III with epirubicin-cisplatin-fluorouracil (ECF) as first-line advanced gastric cancer therapy.Chemotherapy-naïve patients measurable unresectable and/or metastatic carcinoma, performance status <or= 1, and adequate hematologic, hepatic, renal function randomly received eight 3-weekly cycles of ECF (epirubicin 50 mg/m(2) on day...
Background— Intracoronary administration of autologous bone marrow–derived mononuclear cells (BM-MNC) may improve remodeling the left ventricle (LV) after acute myocardial infarction. The optimal time point BM-MNC is still uncertain and has rarely been addressed prospectively in randomized clinical trials. Methods Results— In a multicenter study, we 200 patients with large, successfully reperfused ST-segment elevation infarction 1:1:1 pattern into an open-labeled control 2 treatment groups....
A number of distinct beta-amyloid (Abeta) variants or multimers have been implicated in Alzheimer's disease (AD), and antibodies recognizing such peptides are clinical trials. Humans natural Abeta-specific antibodies, but their diversity, abundance, function the general population remain largely unknown. Here, we demonstrate with peptide microarrays presence against known toxic Abeta amyloidogenic non-Abeta species plasma samples cerebrospinal fluid AD patients healthy controls aged 21-89...
To evaluate the baseline characteristics of patients with radiographic axial spondyloarthritis (SpA; ankylosing spondylitis [AS]) and nonradiographic SpA, to investigate determinants anti-tumor necrosis factor (anti-TNF) agent prescription on background a nonrestrictive reimbursement policy, assess response TNF inhibition.We compared SpA in 1,070 from Swiss Clinical Quality Management (SCQM) Cohort who fulfilled Assessment SpondyloArthritis international Society (ASAS) classification...
<h3>Background</h3> Percutaneous mitral valve repair (MVR) using the MitraClip system has become a valid alternative for patients with severe regurgitation (MR) and high operative risk. <h3>Objective</h3> To identify clinical periprocedural factors that may have an impact on outcome. <h3>Design</h3> Multi-centre longitudinal cohort study. <h3>Setting</h3> Tertiary referral centres. <h3>Patients</h3> Here we report first 100 consecutive treated percutaneous MVR in Switzerland between March...
We study nonparametric maximum likelihood estimation of a log-concave probability density and its distribution hazard function. Some general properties these estimators are derived from two characterizations. It is shown that the rate convergence with respect to supremum norm on compact interval for estimator at least $(\log(n)/n)^{1/3}$ typically $(\log(n)/n)^{2/5}$, whereas difference between empirical estimated function vanishes $o_{\mathrm{p}}(n^{-1/2})$ under certain regularity assumptions.
We find limiting distributions of the nonparametric maximum likelihood estimator (MLE) a log-concave density, that is, density form f0=exp ϕ0 where is concave function on ℝ. The pointwise depend second and third derivatives at 0 Hk, "lower invelope" an integrated Brownian motion process minus drift term depending number vanishing ϕ0=log f0 point interest. also establish distribution resulting mode M(f0) new local asymptotic minimax lower bound which shows optimality our in terms both rate...
Objective To assess the incremental diagnostic value of spine MRI evaluated separately from and combined with sacroiliac joint (SIJ) in non-radiographic axial spondyloarthritis (nr-axSpA) compared SIJ alone. Methods The study sample comprised two independent cohorts A/B 130 consecutive patients aged ≤50 years back pain, newly referred to university clinics, 20 healthy controls. Patients were classified according clinical examination pelvic radiographs as having nr-axSpA (n=50), ankylosing...
<h3>Objective</h3> To determine candidate lesion-based criteria for a positive sacroiliac joint (SIJ) MRI based on bone marrow oedema (BMO) and/or erosion in non-radiographic axial spondyloarthritis (nr-axSpA); to compare the performance of with global evaluation by expert readers. <h3>Methods</h3> Two independent cohorts A/B 69/88 consecutive patients back pain aged ≤50 years, median symptom duration 1.3/10.0 were referred suspected SpA (A) or acute anterior uveitis plus (B). Patients...
Abstract Objective To determine the diagnostic utility of different spinal inflammatory lesions assessed by whole‐body magnetic resonance imaging (MRI) in patients with ankylosing spondylitis (AS) or recent‐onset back pain (IBP) compared healthy controls. Methods We scanned 35 consecutive AS fulfilling modified New York criteria, 25 IBP <24 months' duration (both groups were age ≤45 years and had a Bath Ankylosing Spondylitis Disease Activity Index score ≥4), age‐ sex‐matched volunteers...
Erosions of the sacroiliac joints (SIJ) on pelvic radiographs patients with ankylosing spondylitis (AS) are an important feature modified New York classification criteria. However, radiographic SIJ erosions often difficult to identify. Recent studies have shown that can be detected also magnetic resonance imaging (MRI) early in disease course before they seen radiography. The goals this study were assess reproducibility erosion and related features, namely, extended (EE) backfill (BF)...
BACKGROUND: Since 2003, we have used the Proximal Humerus Interlocking System plate for treatment of proximal humeral fractures. Although many patients good and excellent results, reported rate complications varies. We focused on complication risk factors 1 year after surgery. METHODS: From 2003 until 2008, a total 294 (223 women; 71 men; median age, 72.9) were included. General data collected at time injury (Charlson Index, smoking, steroid therapy). Fractures classified (AO/OTA)...
Epistaxis represents one of the most common emergencies in ENT clinics around world. It creates great physical and emotional stress to patient as well a financial burden on health-care systems. A lot research has been performed with regard aetiology possible treatment, however, not much effort put into analysing effectiveness treatment forms. is objective this study clarify which these forms reliable.Retrospective cohort study.2b.Between 03/2007 04/2008, all epistaxis therapies including...
Abstract A randomized trial allows estimation of the causal effect an intervention compared to a control in overall population and subpopulations defined by baseline characteristics. Often, however, clinical questions also arise regarding treatment patients, which would experience or disease related events post‐randomization. Events that occur after initiation potentially affect interpretation existence measurements are called intercurrent ICH E9(R1) guideline. If event is consequence...
Background— Although newer immunosuppressive agents, such as mTOR (mammalian target of rapamycin) inhibitors, have lowered the occurrence malignancies after transplantation, cancer is still a leading cause death late heart transplantation. Statins may an impact on clinical outcomes beyond their lipid-lowering effects. The aim present study was to delineate whether statin therapy has risk and total mortality Methods Results— A 255 patients who underwent transplantation at University Hospital...