A5088939618- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Cardiac Health and Mental Health
- Blood Pressure and Hypertension Studies
- Veterinary Equine Medical Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cardiovascular and exercise physiology
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Anomaly Detection Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Protease and Inhibitor Mechanisms
- Long-Term Effects of COVID-19
- Reproductive Physiology in Livestock
- Pulmonary Hypertension Research and Treatments
- Animal health and immunology
- Renal Transplantation Outcomes and Treatments
University Hospital of Zurich
2013-2025
HTWG Hochschule Konstanz - Technik, Wirtschaft und Gestaltung
2015-2024
Ludwig-Maximilians-Universität München
2020-2024
LMU Klinikum
2024
See-Spital
2024
Universitätsklinikum Würzburg
2023
Creative Commons
2023
University Hospital of Geneva
1990-2023
University Hospital of Bern
2003-2023
Zürcher RehaZentrum Davos
2012-2023
There are several guidelines addressing the issues around use of NSAIDs. However, none has specifically addressed upper versus lower gastrointestinal (GI) risk COX-2 selective and non-selective compounds nor interaction at both GI cardiovascular (CV) level either class drugs with low-dose aspirin. This Consensus paper aims to develop statements guidance devoted these specific through a review current evidence by multidisciplinary group experts. A modified Delphi consensus process was adopted...
Background: Severe COVID-19 infection often leads to impairments requiring pulmonary rehabilitation (PR) following the acute phase. Little is known about efficacy of PR in these patients. We therefore compared post-COVID-19 patients (PG) referred with other lung diseases (LG). Methods: 99 PG were admitted PR. In a prospective design, results collected and LG 2019 (n = 419) according Functional Independence Measurement (FIM), Cumulative Illness Rating Scale (CIRS), 6-min walk test (6-MWT),...
Background— There is an ongoing debate as to whether the gastrointestinal safety of COX-2 inhibition compared with nonsteroidal antiinflammatory drugs (NSAIDs) may come at cost increased cardiovascular events. In view large number patients risk requiring chronic analgesic therapy inhibitors for arthritic and other inflammatory conditions, effects selective on clinically useful surrogates disease, particularly endothelial function, need be determined. Methods Results— Fourteen male (mean age,...
Background— Dark chocolate has potent antioxidant properties. Coronary atherosclerosis is promoted by impaired endothelial function and increased platelet activation. Traditional risk factors, high oxidative stress, reduced defenses play a crucial role in the pathogenesis of atherosclerosis, particularly transplanted hearts. Thus, flavonoid-rich dark holds potential to have beneficial impact on graft atherosclerosis. Methods Results— We assessed effect compared with cocoa-free control...
Background— Because traditional nonsteroidal antiinflammatory drugs are associated with increased risk for acute cardiovascular events, current guidelines recommend acetaminophen as the first-line analgesic of choice on assumption its greater safety. Data from randomized clinical trials prospectively addressing safety acetaminophen, however, still lacking, particularly in patients at risk. Hence, aim this study was to evaluate coronary artery disease. Methods and Results— The 33 disease...
The COVID-19 pandemic affects a large number of patients with rapid progression respiratory failure often requiring hospitalization or intensive care unit treatment in some patients. Survivors severe experience persistent weakness and cardiorespiratory failure. Feasibility potential benefit cardiopulmonary rehabilitation after remains unclear. Therefore, we retrospectively analyzed cohort single-center inpatient clinic describe performance outcome during rehabilitation.Patients were referred...
Flavanol-rich chocolate (FRC) is beneficial for vascular and platelet function by increasing nitric oxide bioavailability decreasing oxidative stress. Congestive heart failure (CHF) characterized impaired endothelial increased reactivity. As statins are ineffective in CHF, alternative therapies a clinical need. We therefore investigated whether FRC might improve cardiovascular patients with CHF.Twenty CHF were enrolled double-blind, randomized placebo-controlled trial, comparing the effect...
The most serious side effect from statin treatment is myopathy, which may proceed to rhabdomyolysis. This the first study investigate whether pharmacokinetics of either atorvastatin or its metabolites, both, altered in patients with atorvastatin-related myopathy compared healthy controls.A 24-hour pharmacokinetic investigation was performed 14 myopathy. Relevant polymorphisms SLCO1B1 (encoding organic anion transporting polypeptide 1B1), MDR1/ABCB1 P-glycoprotein), and CYP3A5 cytochrome P450...
Background— The excess in cardiovascular risk patients with rheumatoid arthritis provides a strong rationale for early therapeutical interventions. In view of the similarities between atherosclerosis and proven benefit angiotensin-converting enzyme inhibitors atherosclerotic vascular disease, it was aim present study to delineate impact ramipril on endothelial function as well markers inflammation oxidative stress arthritis. Methods Results— Eleven were included this randomized,...
<h3>Introduction</h3> Given the safety issues of non-steroidal anti-inflammatory drugs (NSAID) and robustness guidelines, making treatment choices in daily clinical practice is increasingly difficult. This study aimed systematically to analyse opinions a multidisciplinary European expert panel on appropriateness different NSAID, with or without use proton pump inhibitor (PPI), individual patients chronic rheumatic disease. <h3>Methods</h3> Using Research Development/University California at...
AimsA marked increase in HDL notwithstanding, the cholesterol ester transfer protein (CETP) inhibitor torcetrapib was associated with an all-cause mortality ILLUMINATE trial. As underlying mechanisms remain elusive, present study designed to delineate potential off-target effects of torcetrapib.
Objective Several studies suggest that patients with ankylosing spondylitis (AS) have an increased risk of cardiovascular disease. This study aimed to evaluate the effects a 12‐week, individually monitored, moderate heart rate level intensity training on fitness and perceived disease activity in AS patients. Methods Patients diagnosed according modified New York criteria were randomized either or attention control. The group performed 3 units per week. All participants attended 1 weekly...
Background— In view of the ongoing controversy about potential differences in cardiovascular safety selective cyclooxygenase (COX)-2 inhibitors (coxibs), we compared effects 2 different coxibs and a traditional NSAID on endothelial dysfunction, well-established surrogate disease, salt-induced hypertension. Methods Results— Salt-sensitive (DS) salt-resistant (DR) Dahl rats were fed high-sodium diet (4% NaCl) for 56 days. From days 35 to 56, diclofenac (6 mg · kg −1 d ; DS-diclofenac),...
Background— Despite potential antiinflammatory properties, the use of selective cyclooxygenase-2 inhibitors (coxibs) in patients with cardiovascular diseases has been questioned because a possibly increased thrombotic risk. Tissue factor (TF), key protein for initiation coagulation, implicated pathogenesis atherosclerosis and thrombosis. Hence, we examined effect different coxibs on TF expression. Methods Results— Celecoxib (10 −5 mol/L), but not rofecoxib −7 to 10 mol/L) or experimental...
Background— Although newer immunosuppressive agents, such as mTOR (mammalian target of rapamycin) inhibitors, have lowered the occurrence malignancies after transplantation, cancer is still a leading cause death late heart transplantation. Statins may an impact on clinical outcomes beyond their lipid-lowering effects. The aim present study was to delineate whether statin therapy has risk and total mortality Methods Results— A 255 patients who underwent transplantation at University Hospital...
Summary The incidence of Chronic Obstructive Pulmonary Disease (COPD) in Switzerland was determined three groups horses selected at random. Group A (97 horses) and B (93 had no history respiratory disease, but C (113 a lower tract disease. All were examined by auscultation the under forced, breathing, endoscopic examination upper lower. tract, arterial blood gas analysis rest cytological secretions (RS). Fifty‐four per cent 54.8 diagnosed as suffering clinical COPD only 12.4 8.6 detectable...
Cardiac rehabilitation plays a vital role in secondary prevention of cardiovascular patients. Female sex and higher age, however, are associated with non-referral to cardiac rehabilitation. Improving exercise capacity during is essential reduce morbidity mortality risks. The objective this study was closely examine the beneficial changes older patients both sexes identify most important predictors change capacity.A sample 13,612 (mean age = 69.10 ± 11.8 years, 63.7% men, 19% > 80 years)...
Arterial stiffness is a hallmark of vascular ageing that precedes and strongly predicts the development cardiovascular diseases. Age-dependent stiffening large elastic arteries primarily attributed to increased levels matrix metalloproteinase-2 (MMP-2). However, mechanistic link between age-dependent arterial MMP-2 remains unclear. Thus, we aimed investigate efficacy knockdown using small-interfering RNA (siRNA) on stiffness.Pulse wave velocity (PWV) was assessed in right carotid artery...