A5039973480- Suicide and Self-Harm Studies
- Clinical Laboratory Practices and Quality Control
- Corporate Governance and Management
- Electrolyte and hormonal disorders
- Organ Transplantation Techniques and Outcomes
- Digital Innovation in Industries
- Renal function and acid-base balance
- Metabolomics and Mass Spectrometry Studies
- Flexible and Reconfigurable Manufacturing Systems
- Psychotherapy Techniques and Applications
- Renal Transplantation Outcomes and Treatments
- Psychology, Coaching, and Therapy
- Cardiac Ischemia and Reperfusion
- Diet and metabolism studies
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Potassium and Related Disorders
- Parathyroid Disorders and Treatments
- Treatment of Major Depression
- Venous Thromboembolism Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Gestational Diabetes Research and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University Hospital of Bern
2014-2024
University of Bern
2012-2024
Institute of Molecular Medicine
2005-2023
Universität Hamburg
2006-2022
University Medical Center Hamburg-Eppendorf
2005-2022
HAW Hamburg
2011-2022
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2002-2020
Zentrum für Labormedizin
2013-2019
Heidelberg University
2011-2017
Medical University of Vienna
2017
Abstract The preparation and electrochemical characterization of a new material consisting carbon coated ZnFe 2 O 4 nanoparticles is presented. This material, which offers an interesting combination alloying conversion mechanisms, capable hosting up to nine equivalents lithium per unit formula, corresponding exceptional specific capacity, higher than 1000 mAh g −1 . Composite electrodes such prepared using environmentally friendly sodium carboxymethyl cellulose as binder, showed the highest,...
Age-related macular degeneration (AMD) is the most frequent cause of blindness in elderly. There evidence that nutrition, inflammation and genetic risk factors play an important role development AMD. Recent studies suggest composition intestinal microbiome associated with metabolic diseases through modulation host metabolism. To investigate whether compositional functional alterations are AMD, we sequenced gut metagenomes patients AMD controls. The genera Anaerotruncus Oscillibacter as well...
The aim of our present study was to establish new reference intervals for thyrotropin (TSH) and thyroid hormones based on National Academy Clinical Biochemistry (NACB) criteria regular ultrasonography. We also assessed the effect potentially confounding factors modulate limits these intervals.We investigated 870 apparently healthy persons excluded, step by step, those with a family history disease, pathologic ultrasonography results, increased anti-thyroid peroxidase or anti-thyroglobulin...
Magnetic bead purification for the analysis of low-abundance proteins in body fluids facilitates identification potential new biomarkers by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The aims our study were to establish a proteome fractionation technique and validate standardized blood sampling, processing, storage procedure proteomic pattern analysis.We used magnetic separation profiling human MALDI-TOF MS (mass range, 1000-10,000 Da)...
Background— It is currently unknown whether dietary weight loss interventions can induce regression of carotid atherosclerosis. Methods and Results— In a 2-year Dietary Intervention Randomized Controlled Trial–Carotid (DIRECT-Carotid) study, participants were randomized to low-fat, Mediterranean, or low-carbohydrate diets followed for changes in artery intima-media thickness, measured with standard B-mode ultrasound, vessel wall volume (VWV), 3D ultrasound. Of 140 complete images (aged 51...
Herein, we present a new synthesis method for transition-metal-doped zinc oxide nanoparticles utilized and characterized the first time as anode material lithium-ion batteries. In fact, introduction of transition metal (for instance, iron or cobalt) into lattice results in an advanced performance with reversible lithium storage capacities exceeding 900 mAh g–1, i.e., more than twice that graphite. situ XRD analysis reveals electrochemical reduction wurtzite structure formation LiZn alloy....
Abstract Background: Peptidome profiling of human urine is a promising tool to identify novel disease-associated biomarkers; however, wide range preanalytical variables influence the results peptidome analysis. Our aim was develop standardized protocol for reproducible by means magnetic bead (MB) separation followed matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). Methods: MBs with defined surface functionalities (hydrophobic interaction, cation...
Objective The role of mitochondrial function in the complex pathogenesis type 2 diabetes is not yet completely understood. Therefore, aim this study was to investigate serum concentrations short-, medium- and long-chain acylcarnitines as markers volunteers with normal, impaired or diabetic glucose control. Methods Based on a 75 g oral tolerance test, 1019 studied subjects were divided into group normal (NGT; n = 636), isolated fasting glycaemia (IFG; 184), (IGT; 87) (T2D; 112). Serum free...
Background— Phytosterols are plant-derived sterols that taken up from food and can serve as biomarkers of cholesterol uptake. Serum levels under tight genetic control. We used a genomic approach to study the molecular regulation serum phytosterol potential links coronary artery disease (CAD). Methods Results— A genome-wide association for phytosterols (campesterol, sitosterol, brassicasterol) was conducted in population-based sample KORA (Cooperative Research Region Augsburg) (n=1495) with...
Long-term dietary intervention frequently induces a rapid weight decline followed by stabilization/regain. Here, we sought to identify adipokine biomarkers that may reflect continued beneficial effects of dieting despite partial regain.We analyzed the dynamics fasting serum levels 12 traditional metabolic and novel adipokines among 322 participants in 2-year Dietary Intervention Randomized Controlled Trial (DIRECT) low-fat, Mediterranean, or low-carbohydrate diets for loss.We identified two...
Mass spectrometry-based serum metabolic profiling is a promising tool to analyse complex cancer associated alterations, which may broaden our pathophysiological understanding of the disease and function as source new cancer-associated biomarkers. Highly standardized samples patients suffering from colon (n = 59) controls 58) were collected at University Hospital Leipzig. We based investigations on amino acid screening profiles using electrospray tandem-mass spectrometry. Metabolic evaluated...
OBJECTIVE This study addressed the long-term effect of various diets, particularly low-carbohydrate high-protein, on renal function participants with or without type 2 diabetes. RESEARCH DESIGN AND METHODS In 2-year Dietary Intervention Randomized Controlled Trial (DIRECT), 318 (age, 51 years; 86% men; BMI, 31 kg/m2; mean estimated glomerular filtration rate [eGFR], 70.5 mL/min/1.73 m2; urine microalbumin-to-creatinine ratio, 12:12) serum creatinine <176 μmol/L (eGFR ≥30 m2) were...
A novel analytical platform based on liquid chromatography and tandem mass spectrometry using atmospheric pressure photoionization was applied for the simultaneous quantification of free esterified β-sitosterol, campesterol, brassicasterol, stigmasterol. The total time sample pretreatment analysis could be reduced from ∼3 h [gas chromatography-mass (GC-MS)] to 15 min. detection limits different phytosterols ranged between 0.25 0.68 μg/l. Linear ranges were 1 1,000 within-run between-run...
Mass spectrometry-based serum peptidome profiling is a promising tool to identify novel disease-associated biomarkers, but limited by preanalytic factors and the intricacies of complex data processing. Therefore, we investigated whether standardized sample protocols new bioinformatic tools combined with external validation improve validity for discovery pancreatic cancer-associated markers.For study, two sets sera from patients cancer (n = 40) healthy controls were obtained different...
For chronic depression, the effectiveness of brief psychotherapy has been limited. This study is first comparing long-term cognitive-behavioural therapy (CBT) and psychoanalytic (PAT) chronically depressed patients effects preferential or randomized allocation.A total 252 adults met inclusion criteria (aged 21-60 years, major dysthymia, double depression for at least 24 months, Quick Inventory Depressive Symptoms [QIDS] >9, Beck Depression II [BDI] >17, informed consent, not meeting...