A5070006952- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Sepsis Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Cell Adhesion Molecules Research
- Antimicrobial Resistance in Staphylococcus
- Cardiac electrophysiology and arrhythmias
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intensive Care Unit Cognitive Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
Martin Luther University Halle-Wittenberg
2012-2025
Malteser Krankenhaus St. Anna
2015-2025
St. Marien Hospital
2016-2025
German Society of Medical Intensive Care and Emergency Medicine
2024
German Cardiac Society
2024
University of Siegen
2014-2020
University Hospital in Halle
2008-2018
Marienhospital Stuttgart
2017
Beth Israel Deaconess Medical Center
2017
Universitätsklinikum Tübingen
2016
In the present study, cardioprotective effects of insulin-like growth factor I (IGF-I) were examined in a murine model myocardial ischemia reperfusion (i.e., 20 min + 24 hr). IGF-I (1-10 micrograms per rat) administered 1 hr prior to significantly attenuated injury creatine kinase loss) compared vehicle (P < 0.001). addition, cardiac myeloperoxidase activity, an index neutrophil accumulation, ischemic area was by This protective effect not observed with des-(1-3)-IGF-I....
Tissue factor (TF) is an essential cofactor for the activation of blood coagulation in vivo. We now report that quiescent human platelets express TF pre-mRNA and, response to activation, splice this intronic-rich message into mature mRNA. Splicing associated with increased protein expression, procoagulant activity, and accelerated formation clots. Pre-mRNA splicing controlled by Cdc2-like kinase (Clk)1, interruption Clk1 signaling prevents from accumulating activated platelets. Elevated...
Objective: Patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction with cardiogenic shock (CS) are often treated intra-aortic balloon pump counterpulsation (IABP), even though the evidence to support this is limited. We determined whether IABP as an addition PCI-centered therapy ameliorates multiorgan dysfunction syndrome (MODS) in patients complicated by CS. Design: A prospective, randomized, controlled, open-label clinical trial recruiting between March...
Objective: Multiple organ dysfunction syndrome (MODS) is the sequential failure of several systems after a trigger event, like sepsis or cardiogenic shock. Mortality rate high, up to 70%. Autonomic may substantially contribute development MODS. Our study aimed characterize a) spectrum autonomic critically ill MODS patients; b) whether different in patients receiving sedation, mechanical ventilation, catecholamines; c) age dependency MODS; and d) predicts mortality Design: Prospective cohort...
BACKGROUND Interaction of CD11/CD18 located on neutrophil membranes with its endothelial counter-receptor, intercellular adhesion molecule-1, plays a major role in polymorphonuclear leukocyte (PMN)-mediated dysfunction and myocardial injury associated ischemia reperfusion. However, PMN-derived L-selectin, which is thought to play an early PMN rolling along the vascular endothelium, has not been studied setting METHODS AND RESULTS In this study, we evaluated effects monoclonal antibody...
Recent studies in transgenic mice have revealed that expression of a dominant negative form the transcription factor GATA-3 T cells can prevent helper cell type 2 (Th2)-mediated allergic airway inflammation mice. However, it remains unclear whether plays role effector phase and antagonizing and/or function be used for therapy hyperresponsiveness. Here, we analyzed effects locally murine model asthma. We could suppress interleukin (IL)-4–producing vitro vivo by an antisense phosphorothioate...
Background —Activation of Na + /H exchange in myocardial ischemia and/or reperfusion leads to calcium overload and injury. Experimental studies have shown that inhibitors can attenuate Ca 2+ influx into cardiomyocytes. We therefore performed a multicenter, randomized, placebo-controlled clinical trial test the hypothesis inhibition limits infarct size improves function patients with acute anterior infarction (MI) treated direct PTCA. Methods Results —One hundred were randomized receive...
Background Myocardial injury after ischemia and reperfusion can be attributed largely to the effects of polymorphonuclear leukocytes (PMN). The complement system plays an important role as a chemotactic agent, affecting adhesion molecule expression neutrophil accumulation. Methods Results In present study, cardioprotective C1 esterase inhibitor (C1 INH) were examined in feline model myocardial (90 minutes followed by 270 reperfusion). INH (15 mg/kg) administered 10 before significantly...
We conducted the IABP Cardiogenic Shock Trial (ClinicalTrials.gov ID NCT00469248) as a prospective, randomized, monocentric clinical trial to determine hemodynamic effects of additional intra-aortic balloon pump (IABP) treatment and its on severity disease in patients with acute myocardial infarction complicated by cardiogenic shock (CS). Intra-aortic counterpulsation is recommended CS complicating infarction. However, there are only limited randomized controlled data available supporting...
Cinaciguat (BAY 58-2667) is the first of a new class soluble guanylate cyclase activators in clinical development for acute decompensated heart failure. We aimed to assess hemodynamic effects, safety, and tolerability intravenous cinaciguat patients with failure (pulmonary capillary wedge pressure > or =18 mm Hg).After initial dose finding (part A; n=27), was evaluated nonrandomized, uncontrolled proof-of-concept part study B; n=33) using starting 100 microg/h, which could be titrated...
Background— Stiffening of the aortic wall is a phenomenon consistently observed in age and abdominal aneurysm (AAA). However, its role AAA pathophysiology largely undefined. Methods Results— Using an established murine elastase-induced model, we demonstrate that segmental stiffening precedes growth. Finite-element analysis reveals early aneurysm-prone segment leads to axial (longitudinal) stress generated by cyclic (systolic) tethering adjacent, more compliant segments. Interventional...
Introduction: Infarction-related cardiogenic shock (ICS) is usually due to leftventricular pump failure.With a mortality of 30% 80%, ICS the most common cause death from acute myocardial infarction.The S3 guideline presented here characterizes current evidence-based treatment ICS: early revascularization, shock, and intensive care multi-organ dysfunction syndrome (MODS) if it arises.The success or failure for MODS determines outcome in ICS.
Accelerated arterial stiffening is a major complication of diabetes mellitus with no specific therapy available to date.The present study investigates the role osteogenic transcription factor runt-related 2 (Runx2) as potential mediator and therapeutic target aortic fibrosis in mellitus.Using murine model type (db/db mice), we identify progressive structural that precedes onset hypertension. At same time, Runx2 aberrantly upregulated medial layer db/db aortae, well thoracic samples from...
Neutrophil (PMN) adhesion to the vascular endothelium is an important mechanism of myocardial reperfusion injury. The process initially mediated by selectins (e.g., P- and L-selectin), monoclonal antibodies directed against these molecules exert cardioprotective activity in ischemia/reperfusion models. counterreceptors for are thought be carbohydrate-containing moieties. In this connection, we studied effect a soluble sialyl Lewisx-containing oligosaccharide (SLex-OS) on PMN-endothelial...
Background— Simvastatin, a 3-hydroxy-methylglutaryl coenzyme A reductase inhibitor, has been shown to lower serum cholesterol levels in clinical use. Moreover, statins exert beneficial effects vascular diseases by inhibition of leukocyte rolling, adherence, and transmigration. The aim this study was determine if pretreatment with simvastatin attenuates Staphylococcus aureus α-toxin–induced increase leukocyte-endothelial interactions during exotoxemia. Methods Results— on cell were observed...
The time course of endothelial P-selectin, ICAM-1, and E-selectin expression was studied in a feline model myocardial ischemia reperfusion. Cats were subjected to 90 min followed by 0, 10, 20, 60, 150, or 270 At the end reperfusion, coronary vasculature examined immunohistochemically localize monoclonal antibodies (mAbs) PB1.3, RR1/1, Cy1787 directed against E-selectin, respectively. Immunohistochemical localization for recognized mAb maximally expressed 20 after reperfusion 60 +/- 6%...
We examined the effect of several nitric oxide (NO) donors, authentic NO gas, and L-arginine in isolated cat rat papillary muscles. did not observe significant inotropic effects response to any donor (ie, SPM-5185, C87-3754, S-nitroso-N-acetylpenicillamine [SNAP]) from 1 nmol/L 100 mumol/L. Similarly, NO, at concentrations far excess those that maximally dilate coronary vasculature 500 nmol/L), also failed exert a detectable these preparations. However, presence 5 mumol/L norepinephrine,...
Monocyte chemoattractant protein-1 (MCP-1) is involved in the recruitment of monocytes into arterial vessel wall as one major events leading to atherosclerotic vascular diseases, such coronary artery disease (CAD).The study group comprised 263 volunteers aged between 18 and 85 years who were admitted hospital or clinic for scheduled invasive non-invasive diagnostic procedures. MCP-1 serum levels determined using a sandwich-enzyme-linked immunosorbent assay. In each patient, risk factors...
Sphingomyelin (SM) is the major phospholipid in cell membranes and lipoproteins. In human plasma, SM mainly found atherogenic lipoproteins; thus, high levels of may promote atherogenesis.We investigated a median follow up 6.0 years association with incidence combined endpoint (myocardial infarction cardiovascular death) stable unstable patients, its relation to other marker atherosclerosis 1,102 patients angiographically documented CAD 444 healthy controls.Logistic regression analysis showed...
Objectives: Levosimendan improves left ventricular hemodynamic function in patients with cardiogenic shock. However, its impact on right performance has not been determined. We compared the effects of levosimendan and intractable shock following myocardial infarction. Design: Observational study. Setting: Tertiary care center university hospital. Patients: Fifty-six secondary to infarction were treated percutaneous revascularization (including intra-aortic balloon pump when appropriate)...