Helena Marzo‐Ortega
A5053315948- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Bone and Joint Diseases
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dermatology and Skin Diseases
- Spine and Intervertebral Disc Pathology
- Ocular Diseases and Behçet’s Syndrome
- Inflammatory Bowel Disease
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Sclerosis and Related Diseases
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Autoimmune Bullous Skin Diseases
- Musculoskeletal Disorders and Rehabilitation
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Osteoarthritis Treatment and Mechanisms
- Autoimmune and Inflammatory Disorders
- Liver Diseases and Immunity
- Nail Diseases and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Medical and Biological Sciences
University of Leeds
2016-2025
Leeds Teaching Hospitals NHS Trust
2016-2025
NIHR Leeds Musculoskeletal Biomedical Research Unit
2016-2025
Chapel Allerton Hospital
2013-2024
National Institute for Health Research
2016-2024
Charité - Universitätsmedizin Berlin
2021-2024
Humboldt-Universität zu Berlin
2024
Freie Universität Berlin
2024
Sheba Medical Center
2024
Tel Aviv University
2024
Background Since the publication of European League Against Rheumatism recommendations for pharmacological treatment psoriatic arthritis (PsA) in 2012, new evidence and therapeutic agents have emerged. The objective was to update these recommendations. Methods A systematic literature review performed regarding PsA. Subsequently, were formulated based on expert opinion 34 Task Force members. Levels strengths allocated. Results updated comprise 5 overarching principles 10 recommendations,...
Nature Communications 6: Article number: 6046 (2015); Published 5 February 2015; Updated 6 July 2015 The affiliation details for Emiliano Giardina are incorrect in this Article. correct address author is given below: Department of Biopathology, Centre Excellence Genomic Risk Assessment Multifactorial and Complex Diseases, School Medicine, University Rome 'Tor Vergata' Laboratory Molecular Genetics UILDM, Fondazione Santa Lucia, 00179, Italy.
<h3>Background:</h3> Magnetic resonance imaging (MRI) of sacroiliac joints has evolved as the most relevant modality for diagnosis and classification early axial spondyloarthritis (SpA) including ankylosing spondylitis. <h3>Objectives:</h3> To identify describe MRI findings in sacroiliitis to reach consensus on which are essential definition sacroiliitis. <h3>Methods:</h3> Ten doctors (two radiologists eight rheumatologists) from ASAS/OMERACT working group reviewed discussed three workshops...
To update the European League Against Rheumatism (EULAR) recommendations for pharmacological treatment of psoriatic arthritis (PsA).According to EULAR standardised operating procedures, a systematic literature review was followed by consensus meeting develop this involving 28 international taskforce members in May 2019. Levels evidence and strengths were determined.The updated comprise 6 overarching principles 12 recommendations. The address nature PsA diversity both musculoskeletal...
To update the Assessment of SpondyloArthritis international Society (ASAS)-EULAR recommendations for management axial spondyloarthritis (axSpA).Following EULAR Standardised Operating Procedures, two systematic literature reviews were conducted on non-pharmacological and pharmacological treatment axSpA. In a task force meeting, evidence was presented, discussed, overarching principles updated, followed by voting.Five 15 with focus personalised medicine agreed: eight remained unchanged from...
Background Psoriatic arthritis (PsA) is a clinically heterogeneous disease. Clear consensual treatment guidance focused on the musculoskeletal manifestations of PsA would be advantageous. The authors present European League Against Rheumatism (EULAR) recommendations for with systemic or local (non-topical) symptomatic and disease-modifying antirheumatic drugs (DMARD). Methods are based evidence from systematic literature reviews performed non-steroidal anti-inflammatory (NSAID),...
Magnetic resonance imaging (MRI) is increasingly used to detect sacroiliitis earlier. This study was undertaken investigate what proportion of patients with MRI-evident develop ankylosing spondylitis (AS) in the long term and whether there are predictors outcome.Consecutive undiagnosed early inflammatory back pain (IBP) (of <2 years' duration) were assessed clinically radiologically. Baseline assessments included fat-suppressed MRI sequences sacroiliac joints lumbar spine that scored for...
Infectious diseases and vaccines can occasionally cause new-onset or flare of immune-mediated (IMDs). The adjuvanticity the available SARS-CoV-2 is based on either TLR-7/8 TLR-9 agonism, which distinct from previous a common pathogenic mechanism in IMDs.We evaluated IMD flares new disease onset within 28-days vaccination at five large tertiary centres countries with early adoption, three Israel, one UK, USA. We assessed pattern expression terms autoimmune, autoinflammatory, mixed phenotype...
Objective To develop new composite disease activity indices for psoriatic arthritis (PsA). Methods Data from routine clinic visits at multiple centres were collected in a systematic manner. included all domains identified as important randomised controlled trials PsA. Decisions to change treatment used surrogates high activity. New developed by linear regression (psoriatic score: PASDAS) and empirically, utilising physician-defined cut-offs (arithmetic mean of desirability functions: AMDF)....
<h3>Objective</h3> The aim of this study was to define characteristic MRI findings in the spine patients with axial spondyloarthritis (SpA) and provide a definition positive spinal for inflammation structural changes. <h3>Methods</h3> Technical details description lesions both changes were discussed consecutive meetings 10 experts Assessment SpondyloArthritis international Society (ASAS). discussions aimed at broad consensus on definitions 'a MRI' types backed up by systematic literature...
Objectives The Assessment of SpondyloArthritis international Society (ASAS) MRI working group (WG) was convened to generate a consensus update on standardised definitions for lesions in the sacroiliac joint (SIJ) patients with spondyloarthritis (SpA), and conduct preliminary validation. Methods literature pertaining these lesion discussed at three meetings group. 25 investigators (20 rheumatologists, 5 radiologists) determined which should be retained or required revision, new definition....
<h3>Background</h3> Increased risk of some comorbidities has been reported in spondyloarthritis (SpA). Recommendations for detection/management these have proposed, and it is known that a gap exists between their implementation practice. <h3>Objective</h3> To evaluate (1) the prevalence factors different countries worldwide, (2) available recommendations daily practice management (3) previously unknown detected as result present initiative. <h3>Methods</h3> Cross-sectional international...
<h3>Objectives</h3> The burden of disease in patients with ankylosing spondylitis (AS) can be considerable. However, no agreement has been reached among expert members Assessment SpondyloArthritis International Society (ASAS) to define severity AS. Based on the Classification Functioning, Disability and Health (ICF), a core set items for AS selected represent entire spectrum possible problems functioning. this, objective this study was develop tool quantify health AS, ASAS Index....
Apremilast, an oral phosphodiesterase 4 inhibitor, downregulates intracellular inflammatory mediator synthesis by elevating cyclic adenosine monophosphate levels. The PALACE 2 trial evaluated apremilast efficacy and safety in patients with active psoriatic arthritis (PsA) despite prior conventional disease-modifying antirheumatic drugs and/or biologic therapy.Eligible were randomized (1:1:1) to placebo, 20 mg BID, or 30 BID. At Week 16, swollen tender joint count improvement < 20% entered...
<h3>Background</h3> The transition from psoriasis (PsO) to psoriatic arthritis (PsA) and the early diagnosis of PsA is considerable scientific clinical interest for prevention interception PsA. <h3>Objective</h3> To formulate EULAR points consider (PtC) development data-driven guidance consensus trials practice in field or management people with PsO at risk development. <h3>Methods</h3> A multidisciplinary task force 30 members 13 European countries was established, standardised operating...
Ankylosing spondylitis (AS) is the historic term used for decades HLA-B27-associated inflammatory disease affecting mainly sacroiliac joints (SIJ) and spine. Classification criteria AS have radiographic sacroiliitis as a dominant characteristic. However, with availability of MRI SIJ, it could be demonstrated that starts long before definite SIJ changes become visible on radiographs. The Assessment SpondyloArthritis international Society, representing worldwide group experts reached consensus...