Francisca Sivera
A5077679640- Gout, Hyperuricemia, Uric Acid
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Urticaria and Related Conditions
- Musculoskeletal Disorders and Rehabilitation
- Case Reports on Hematomas
- Vasculitis and related conditions
- Innovations in Medical Education
- Otitis Media and Relapsing Polychondritis
- Medical and Biological Sciences
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Musculoskeletal synovial abnormalities and treatments
- Inflammasome and immune disorders
- Ocular Diseases and Behçet’s Syndrome
- Eosinophilic Disorders and Syndromes
- Clinical Reasoning and Diagnostic Skills
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Bone and Joint Diseases
- Venous Thromboembolism Diagnosis and Management
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Atherosclerosis and Cardiovascular Diseases
Hospital General de Elda
2016-2025
Universitat de Miguel Hernández d'Elx
2009-2025
FC Barcelona
2018
Hospital General Universitario de Alicante Doctor Balmis
2007-2016
University of Auckland
2016
University of Pennsylvania
2016
Veterans Health Administration
2015
Hospital Universitário Pedro Ernesto
2015
University of Otago
2015
University of Genoa
2015
Objectives To agree terminology and to develop recommendations for the diagnosis of calcium pyrophosphate deposition (CPPD). Methods The European League Against Rheumatism (EULAR) CPPD Task Force, comprising 15 experts from 10 countries, agreed terms using a Delphi consensus approach. Evidence was systematically reviewed presented in sensitivity, specificity positive likelihood ratio (LR) support diagnosis; ORs were used association. Strength recommendation (SOR) assessed by EULAR visual...
Magnetic resonance imaging (MRI) is increasingly used to detect sacroiliitis earlier. This study was undertaken investigate what proportion of patients with MRI-evident develop ankylosing spondylitis (AS) in the long term and whether there are predictors outcome.Consecutive undiagnosed early inflammatory back pain (IBP) (of <2 years' duration) were assessed clinically radiologically. Baseline assessments included fat-suppressed MRI sequences sacroiliac joints lumbar spine that scored for...
Objectives To develop evidence-based recommendations for management of calcium pyrophosphate deposition (CPPD). Methods A multidisciplinary guideline development group 15 experts, representing 10 European countries, generated key propositions CPPD using a Delphi consensus approach. For each recommendation research evidence was searched systematically. Whenever possible, the effect size and number needed to treat efficacy RR or OR side effects were calculated individual treatment modalities....
Objective Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) EULAR have developed the first‐ever CPPD disease. Methods Supported by ACR EULAR, a multinational group investigators followed established methodology to develop these criteria. generated lists candidate items refined their definitions, collected de‐identified patient...
Discussion and voting at OMERACT 9 confirmed 5 essential domains for outcomes of acute gout: pain, joint swelling, tenderness, patient global assessment activity limitations. For studies in chronic gout 7 are: serum urate, attacks, tophus burden, health-related quality life, limitations, assessment. Implications perspectives, discretionary specific studies, measurement instruments a possible responder index are under study.
<b>Objectives:</b> To determine whether hypouricaemic treatment results in the disappearance of urate crystals from gouty joints and to define time required. <b>Methods:</b> In 18 patients with monosodium (MSU) crystal proven gout, after initiation successful serum uric acid (SUA)-lowering treatment, an arthrocentesis asymptomatic signal joint (11 knees, 7 first metatarsophalangeal joints) was performed every 3 months obtain a synovial fluid (SF) sample. The sample then analysed for presence...
Objective To determine which clinical, laboratory, and imaging features most accurately distinguished gout from non‐gout. Methods We performed a cross‐sectional study of consecutive rheumatology clinic patients with ≥1 swollen joint or subcutaneous tophus. Gout was defined by synovial fluid tophus aspirate microscopy certified examiners in all patients. The sample randomly divided into model development (two‐thirds) test (one‐third). Univariate multivariate association between clinical...
Objective To examine the performance of ultrasound (US) for diagnosis gout using presence monosodium urate monohydrate (MSU) crystals as gold standard. Methods We analyzed data from Study Updated Gout Classification Criteria (SUGAR), a large, multicenter observational cross‐sectional study consecutive subjects with at least 1 swollen joint who conceivably may have gout. All underwent arthrocentesis; cases were confirmed MSU crystals. Rheumatologists or radiologists blinded regard to results...
<h3>Objective</h3> There is a lack of standardisation in the terminology used to describe gout. The aim this project was develop consensus statement describing recommended nomenclature for disease states <h3>Methods</h3> A content analysis gout-related articles from rheumatology and general internal medicine journals published over 5-year period identified potential labels commonly assigned them. Based on these findings, experts gout were invited participate Delphi exercise face-to-face...
Objective The language currently used to describe gout lacks standardization. aim of this project was develop a consensus statement on the labels and definitions basic disease elements gout. Methods Experts in (n = 130) were invited participate Delphi exercise face‐to‐face meeting reach labeling for Disease current use derived from content analysis contemporary medical literature, results item selection meeting. Results There 51 respondents 30 attendees at Consensus agreement (≥80%) achieved...
Objective To evaluate the association between monosodium urate (MSU) crystal deposits in patients with asymptomatic hyperuricemia and severity extension of coronary artery disease (CAD). Methods In this cross‐sectional study, consecutive inpatients a non–ST elevation acute event (serum uric acid concentration ≥7.0 mg/dl) or normouricemia <7.0 were enrolled. hyperuricemia, presence MSU crystals was determined by ultrasound evaluation both knees first metatarsophalangeal joints compensated...
Objective To perform external validation of a provisional definition disease flare in patients with gout. Methods Five hundred nine gout were enrolled cross‐sectional study during routine clinical care visit at 17 international sites. Data collected to classify as experiencing or not flare, according definition. A local expert rheumatologist performed the final independent adjudication status. Sensitivity, specificity, predictive values, and receiver operating characteristic ( ROC ) curves...
Objectives To investigate how the first wave of COVID-19 pandemic influenced decisions rheumatologists and health professionals in rheumatology regarding management patients with inflammatory rheumatic musculoskeletal diseases (RMDs). Methods An English-language questionnaire was developed by a EULAR working group distributed via national societies countries, EMEUNET individual members. Responses were collected using an online survey tool. Descriptive statistics calculated. Results We...
Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) EULAR have developed the first-ever CPPD disease.Supported by ACR EULAR, a multinational group investigators followed established methodology to develop these criteria. generated lists candidate items refined their definitions, collected de-identified patient profiles,...
Various nonvalidated criteria for disease flare have been used in studies of gout. Our objective was to develop empirical definitions a gout from patient-reported features.Possible elements were previously reported. Data collected 210 patients at 8 international sites evaluate potential against the gold standard an expert rheumatologist definition. Flare based on presence number independently associated with and classification regression tree approaches developed.The mean ± SD age study...
To establish consensus for potential remission criteria to use in clinical trials of gout.Experts (n = 88) gout from multiple countries were invited participate a web-based questionnaire study. Three rounds Delphi exercises conducted using SurveyMonkey, followed by discrete-choice experiment 1000Minds software. The focused on identifying domains, definitions each domain, and the timeframe over which should be defined.There 49 respondents (56% response) initial survey, with subsequent...
To describe and assess the response to short-term etoricoxib as shown by MRI clinical variables in patients with ankylosing spondylitis (AS) selected for eligibility anti-tumour necrosis factor therapy.In a 6-week open-label study, 22 AS eligible biological therapy were treated 90 mg of daily. Clinical laboratory parameters obtained sacroiliac joints lower thoracic lumbar spine performed at baseline week 6. The primary end point was proportion fulfilling SpondyloArthritis international...
Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence in Spain are scarce. In EPISER2016 study, promoted Spanish Society Rheumatology, estimate general adult population has been updated its association with sociodemographic, anthropometric lifestyle variables explored.Population-based multicentre cross-sectional multistage stratified cluster random sampling. Participants were contacted telephone to carry out a...