A5025281977- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Bone and Joint Diseases
- Hepatitis B Virus Studies
- Gout, Hyperuricemia, Uric Acid
- Inflammatory Myopathies and Dermatomyositis
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Hepatitis C virus research
- Urticaria and Related Conditions
- Liver Disease Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Natural Compounds in Disease Treatment
- Salivary Gland Disorders and Functions
- Mast cells and histamine
- Atherosclerosis and Cardiovascular Diseases
- Osteomyelitis and Bone Disorders Research
- Liver Diseases and Immunity
Taipei Veterans General Hospital
2013-2023
Fu Jen Catholic University
2023
National Yang Ming Chiao Tung University
2012-2022
Taipei Tzu Chi Hospital
2022
Weatherford College
2022
Faculty (United Kingdom)
2020
National Yang Ming University Hospital
2009-2019
Chi Mei Medical Center
2010
National Science and Technology Council
2010
Buddhist Tzu Chi General Hospital
2010
<h3>Objective:</h3> To validate and refine two sets of candidate criteria for the classification/diagnosis axial spondyloarthritis (SpA). <h3>Methods:</h3> All Assessment SpondyloArthritis international Society (ASAS) members were invited to include consecutively new patients with chronic (⩾3 months) back pain unknown origin that began before 45 years age. The first tested in entire cohort 649 from 25 centres, then refined a random selection 40% cases thereafter validated remaining 60%....
Distinguishing true cellulitis from its many imitators is challenging but critical if we are to avoid unnecessary use of antibiotics and delays in treatment. Common stasis dermatitis, lipodermatosclerosis, contact lymphedema, eosinophilic cellulitis, papular urticaria. Specific criteria do not exist for the diagnosis alert physician can find clues history physical examination that point toward cellulitis.
We sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong capacity discriminate cases of ankylosing spondylitis (AS) from healthy controls and individuals in community with chronic back pain.PRSs were developed validated European East Asian ethnicity, using data genome-wide association studies 15 585 AS 20 452 controls. The discriminatory values PRSs these populations compared other widely used diagnostic tests, including C-reactive protein (CRP), HLA-B27 sacroiliac...
Tripterygium wilfordii Hook F(TWH), commonly known as the Thunder-God-Vine, is a popular remedy for rheumatism in southern China. In this study, we investigated effect of T2 (an extract from TWH) on adjuvant-induced paw oedema rats and inflammatory mediators. The results showed that an intraperitoneal injection could significantly decrease rats. During vitro lipopolysaccharide (LPS)-stimulated human mononuclear prostaglandin E2 (PGE2) culture supernatant was inhibited by at concentration 2...
Various nonvalidated criteria for disease flare have been used in studies of gout. Our objective was to develop empirical definitions a gout from patient-reported features.Possible elements were previously reported. Data collected 210 patients at 8 international sites evaluate potential against the gold standard an expert rheumatologist definition. Flare based on presence number independently associated with and classification regression tree approaches developed.The mean ± SD age study...
Background: Ankylosing spondylitis (AS) is a chronic arthritis with pathogenesis which not fully understood. A third subset of IL-17-producing T helper cells, called Th17 has been discovered and characterized. We investigated whether IL-17 IL-23, two Th17-related cytokines, play any roles in the of, have correlations with, disease activity clinical manifestations AS. Methods: This cross-sectional study included 49 AS patients 25 healthy control subjects. The serum IL-23 levels were measured...
Ankylosing spondylitis (AS) is a type of axial inflammation. Over time, some patients develop spinal ankylosis and permanent disability; however, current treatment strategies cannot arrest syndesmophyte formation completely. Here, we used mesenchymal stem cells (MSCs) from AS (AS MSCs) within the enthesis involved in to delineate that HLA-B27–mediated spliced X-box–binding protein 1 (sXBP1)/retinoic acid receptor-β (RARB)/tissue-nonspecific alkaline phosphatase (TNAP) axis accelerated...
Objective. To submit serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) to statistical analyses test their exact degrees clinical usefulness as biomarkers for detecting high disease activity in ankylosing spondylitis (AS), comparing them with erythrocyte sedimentation rate (ESR) C-reactive protein (CRP).
Carriage of HLA-B60 has been shown to increase the risk ankylosing spondylitis (AS) in B27-positive Caucasian patients, but association B27-negative cases is less certain. This study assessed HLA class I gene associations Chinese HLA-B27-negative AS patients.Forty-one patients fulfilling modified New York diagnostic criteria for were recruited, and 11 383 blood donors used comparison. HLA-A -B typing was done with microlymphocytotoxicity assay.Among 21 male 20 female. Of HLA-B alleles, only...
Objective. The aim of our study was to compare the clinical, functional, and radiographic outcomes at different ages onset in patients with ankylosing spondylitis (AS). Methods. A total 546 were enrolled consecutively classified into 3 groups based on their age symptom onset: (1) juvenile-onset AS (age ≤ 16 years; JoAS); (2) adult-onset (> but < 40 AoAS); (3) late-onset (≥ LoAS). We compared differences among groups. OR for disease calculated adjusted sex, HLA-B27, duration. Results....
Abstract Clinically detectable joint swelling was found in 10 of 13 fully evaluated patients considered to have polymyalgia rheumatica. Five had some findings at disease onset. Knees were most commonly affected. Sternoclavicular involvement seen 3 patients. Joint effusions 8 300–5,700 leukocytes/mm with a mean 2,900. Six synovial biopsy specimens studied by light microscopy revealed mild moderate proliferation and chronic inflammation that generally less severe than typical rheumatoid...
Objective. To measure serum concentrations of bone morphogenetic proteins (BMP) in patients with ankylosing spondylitis (AS), and to investigate the relationship between BMP clinical manifestations radiographic changes. Methods. We studied 60 consecutive AS without spinal fusion. Spinal radiographs were assessed using Bath Ankylosing Spondylitis Radiology Index (BASRI) modified Stoke Score (mSASSS). fusion was defined as presence total bony bridging 2 adjacent vertebral bodies either lumbar...
HLA-Cw*06 has a strong influence on the clinical features and susceptibility to psoriasis in different ethnicities. It is also used as biomarker predict therapeutic efficacy of biologics, with inconsistent results. Additionally, most Asian patients do not carry HLA-Cw*06.To determine additional HLA alleles which confer or affect severity Chinese Han individuals. In addition, potential using treatment outcomes was investigated.We conducted case-control association study 199 200 unrelated...
This study aimed to identify the risk factors for mortality and impact of dialysis modalities on survival in SLE patients with end-stage renal disease (ESRD).This retrospective nationwide population-based using National Health Insurance Research Database Taiwan collected data from 1073 ESRD starting maintenance between March 1997 December 2006. A multivariate Cox regression hazard model was applied predicting cohorts different outcome these both genders.The major threat infections. For...
Recent studies have suggested that apoptosis is one of the pathogenetic mechanisms in rheumatoid arthritis (RA). In this study, by using single and double immunohistochemical staining assays, Fas, Fas-L, p53, Bcl-2 were measured simultaneously RA osteoarthritic (OA) post-traumatic (PT) synovial tissues (ST) order to understand distribution these apoptosis-related proteins. The TdT-mediated dUTP-biotin nick end labelling (TUNEL) method was performed detect apoptotic cells. There a significant...