A5048655668- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Gout, Hyperuricemia, Uric Acid
- Inflammasome and immune disorders
- Alcohol Consumption and Health Effects
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Hip disorders and treatments
- Neurogenetic and Muscular Disorders Research
- Epigenetics and DNA Methylation
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- Bone and Joint Diseases
- Endometrial and Cervical Cancer Treatments
- Liver Diseases and Immunity
- Osteomyelitis and Bone Disorders Research
- COVID-19 Clinical Research Studies
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Advanced Glycation End Products research
National Yunlin University of Science and Technology
2024
National Taiwan University Hospital
2023-2024
National Taiwan University
2023-2024
National Yang Ming Chiao Tung University
2023-2024
China Medical University Hospital
2021-2022
China Medical University
2021-2022
Chung Shan Medical University Hospital
2022
Taipei Tzu Chi Hospital
2015-2021
Tzu Chi University
2015-2021
Buddhist Tzu Chi Medical Foundation
2021
Ankylosing spondylitis (AS) is a type of axial inflammation. Over time, some patients develop spinal ankylosis and permanent disability; however, current treatment strategies cannot arrest syndesmophyte formation completely. Here, we used mesenchymal stem cells (MSCs) from AS (AS MSCs) within the enthesis involved in to delineate that HLA-B27–mediated spliced X-box–binding protein 1 (sXBP1)/retinoic acid receptor-β (RARB)/tissue-nonspecific alkaline phosphatase (TNAP) axis accelerated...
Backgrounds & aimsPlant-based diets may target multiple pathways in gout pathogenesis (uric acid reduction and anti-inflammation) while improving associated cardiometabolic comorbidities. We aim to prospectively examine the relationship between a vegetarian diet gout, explore if this is independent of hyperuricemia.MethodsWe followed 4903 participants Tzu Chi Health Study (Cohort1, recruited 2007–2009) 9032 Vegetarian (Cohort2, 2005) until end 2014. Baseline serum uric was measured Cohort1....
T follicular helper (Tfh) cell-derived signals promote activation and proliferation of antigen-primed B cells. It remains unclear whether epigenetic regulation is involved in the cell responses to Tfh signals. Here, we demonstrate that cell-mimicking induce expression histone demethylases KDM4A KDM4C, concomitant global down-regulation their substrates, H3K9me3/me2, Depletion KDM4C potentiates response ChIP-seq de novo motif analysis reveals NF-κB p65 as a binding partner KDM4C. Their...
Abstract Aim To investigate total and central obesity in ankylosing spondylitis (AS), assess the association with inflammation, disease severity cardiovascular risk factors. Methods There were 105 AS patients enrolled. Anthropometry was measured to determine (body mass index [BMI]) (waist circumference [WC], waist‐to‐height ratio [WHtR]). We evaluated patients’ activity, functional ability, global assessment, physical mobility, radiographic damage health index. Erythrocyte sedimentation...
We aimed to evaluate the risk of valvular heart disease (VHD) among patients with ankylosing spondylitis (AS).This was a population-based cohort study utilizing Longitudinal Health Insurance Research Database National in Taiwan. Patients and without coding newly diagnosed AS from 1999 2013 were assigned non-AS groups, respectively. Primary outcome incidental VHD. Multiple Cox regression used estimate adjusted hazard ratio Subgroup analysis sensitivity tests also conducted.The group included...
In Taiwan, the incidence and prevalence of psoriatic arthritis (PsA) have risen significantly in recent years. Moreover, data from Taiwan National Health Insurance Research Database (NHIRD) show that more than 85% PsA patients are treated with just non-steroidal anti-inflammatory drugs (NSAIDs) and/or conventional synthetic disease-modifying anti-rheumatic (csDMARDs). Taiwanese clinicians also expressed concerns regarding uncertainties diagnosis delayed, interrupted, tapered use biologics,...
The relationship between endometriosis and the ensuing risk of Sjögren's syndrome has remained unclear. This study aims to present epidemiological evidence for this connection. is a retrospective cohort patients (ICD-9-CM 617.0-617.9 621.3) matched comparison group 2000 2012 in National Taiwan Insurance Research Database. After age matching, we analyzed association 710.2). We used Cox proportional hazard model examine ratio incidental syndrome. Subgroup analyses on age, comorbidities,...
Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs capable rapidly producing copious amounts type I IFN (IFN-I) in response to viral infections. The mechanism regulating rapid production IFN-I after pDCs exposed nucleic acids remains elusive. Here, we show that the transcription factor Blimp-1 is promptly induced exposure TLR7 and TLR9 ligands via unique Ras-related C3 botulinum toxin substrate (Rac)-mediated pathway. Deletion Prdm1 gene encoding impaired IFN-I, but not...
Purpose: Previous studies have shown that metformin exhibits an anti-inflammatory effect and may decrease the risk of incidental diabetes. But on Sjögren's syndrome is unknown. The aim study was to examine association between exposure in diabetic patients. Methods: dataset this retrospective cohort obtained from National Health Insurance Research Database (2000-2013) Taiwan. In total, 15,098 type 2 patients under treatment equivalent number without matched for comparison were included....
Human leukocyte antigen (HLA)-B27 is the genetic marker for ankylosing spondylitis (AS). Here, we generated induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear of a male AS patient carrying HLA-B27 with syndesmophyte formation by using Sendai-virus delivery system. The resulting iPSCs had normal karyotype, expressed markers, and could differentiate into three germ layers. This cellular model will provide platform studying pathological mechanisms new bone in positive patients.
Abstract Although human leucocyte antigen (HLA)‐B27 is strongly associated with ankylosing spondylitis (AS), the association of unfolded protein response (UPR) induced by HLA‐B27 misfolding in AS remains controversial. Since dendritic cells (DCs) are crucial induction HLA‐B27‐transgenic rats, and plasmacytoid DCs (pDCs) belong to one type DCs, we here aim study relevance pDCs UPR AS. Peripheral were isolated from 27 HLA‐B27(+) patients 37 controls. The bone marrow (BM) synovium inflamed hips...
Methods. Serum levels of soluble HLA-G (sHLA-G) were measured in 80 AS patients and 30 healthy controls. The expression on the peripheral blood mononuclear cell (PBMC) surface was investigated same 40 controls by flow cytometry. response after 3 months TNF-α blocker therapy (adalimumab) evaluated 14 patients. We Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Functional (BASFI), Patient Global Score (BAS-G), physical mobility, ESR CRP levels.
Background To investigate the association between a history of acute anterior uveitis (AAU) and risk major adverse cardiovascular events (MACE) among patients with ankylosing spondylitis (AS). Methods We identified 38,691 newly diagnosed AS 2003 2013 from Taiwan National Health Insurance Research Database. The exposure group was defined as people diagnosis by ophthalmologist before date. incidence MACE in according to International Classification Diseases, Ninth Revision. randomly selected...
Objective. Ankylosing spondylitis (AS) is a highly heritable disease with HLA-B27 being the strongest susceptible gene. In order to survey environmental triggers for arthritis development, we used high-throughput technique screen effects of 12,264 chemicals on gene promoter. Methods. Promoter reporter transfectants 293T-HLA-B27 and HeLa-HLA-B27 were tested using robotics chemicals. Chemicals that modulated promoter activity > 150% or < 40% selected further evaluation IC50/EC50 cell...
Objective: To clarify the effect of methylprednisolone (MP) pulse therapy on renal function and analyze risk factors. Methods: Forty-nine patients with collagen vascular diseases were included, whom 26 assigned in nephritis group SLE or Sjogren's syndrome other 23 without involvements. Results: Before MP therapy, showed a significantly higher prevalence Leucopenia (p=0.028), low C3/C4 (p＜0.001), positive ANA (p=0.015), SSA/SSB (p＜0.001) when compared nephritis. After 3-consecutive-day 1000...
Full text available Keywords: Demographic, ankylosing spondylitis, Chinese, peripheral arthritis, uveitis, BASDAI, BASFI