A5050577115- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Salivary Gland Disorders and Functions
- Chronic Lymphocytic Leukemia Research
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Bone and Joint Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IgG4-Related and Inflammatory Diseases
- Inflammatory Myopathies and Dermatomyositis
- Vasculitis and related conditions
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Otitis Media and Relapsing Polychondritis
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Complement system in diseases
- Hepatitis B Virus Studies
- Dermatological and Skeletal Disorders
- Salivary Gland Tumors Diagnosis and Treatment
Taipei Veterans General Hospital
2010-2025
Taipei Medical University
2015-2025
National Yang Ming Chiao Tung University
2010-2025
Weatherford College
2022
Taipei Tzu Chi Hospital
2022
Wan Fang Hospital
2006-2020
National Yang Ming University Hospital
2005-2007
R.O.C Military Academy
2005
<b>Objective:</b> To evaluate the changes in anti-cyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor (RF) following etanercept treatment patients with arthritis. <b>Methods:</b> The study included 90 arthritis who failed disease modifying antirheumatic drugs (DMARDs). All were allowed to continue DMARDs; 52 of them received as a twice weekly 25 mg subcutaneous injection for three months, others did not. Serum samples collected at baseline one month intervals during...
Objective. To submit serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) to statistical analyses test their exact degrees clinical usefulness as biomarkers for detecting high disease activity in ankylosing spondylitis (AS), comparing them with erythrocyte sedimentation rate (ESR) C-reactive protein (CRP).
Objective. The aim of our study was to compare the clinical, functional, and radiographic outcomes at different ages onset in patients with ankylosing spondylitis (AS). Methods. A total 546 were enrolled consecutively classified into 3 groups based on their age symptom onset: (1) juvenile-onset AS (age ≤ 16 years; JoAS); (2) adult-onset (> but < 40 AoAS); (3) late-onset (≥ LoAS). We compared differences among groups. OR for disease calculated adjusted sex, HLA-B27, duration. Results....
To investigate the correlations among cytokines and regulatory T cells (T-regs) in ankylosing spondylitis (AS) patients, their changes after anti-tumour necrosis factor-α (TNF-α) treatment. We included 72 AS patients with detailed medical records, disease activity score (Bath Ankylosing Spondylitis Disease Activity Index), functional index Functional laboratory data (interleukin (IL)-2, IL-4, IL-10, TNF-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, ESR, CRP). Their peripheral...
The role of mitochondrial DNA (mtDNA) alterations in the pathophysiology systemic lupus erythematosus (SLE) remains unclear. We investigated sequence variations D310 region and copy number change mtDNA 85 SLE patients 45 normal subjects. Leukocyte RNA were extracted from leukocytes peripheral venous blood. mtDNA, mRNA expression levels mtDNA-encoded genes determined by quantitative real-time polymerase chain reaction (Q-PCR) PCR-based direct sequencing, respectively. found that leukocyte...
To determine bone morphogenetic proteins (BMPs) and Dickkopf homologue-1 (Dkk-1) levels in ankylosing spondylitis (AS).Serum BMPs Dkk-1 were measured 72 AS patients 30 healthy controls. For patients, we recorded the demographic data, disease activity, functional index, global assessment with questionnaires, image changes roentgenography. We also human leucocyte antigen-B27 systemic inflammatory reactants.BMPs higher but was significantly lower than who received non-steroidal...
Rheumatoid arthritis (RA) is a systematic autoimmune disease, predominantly causing chronic polyarticular inflammation and joint injury of patients. For the treatment RA, biologic disease-modifying antirheumatic drugs (bDMARDs) have been used to reduce interfere with disease progression through targeting mediating immune system. Although therapeutic effects bDMARDs in RA patients widely reported, whether these also play important roles T-cell repertoire status still unclear. We therefore...