A5109255263- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- Hydrology and Watershed Management Studies
- Ferroelectric and Negative Capacitance Devices
- Semiconductor materials and devices
- Medical Imaging Techniques and Applications
- Microtubule and mitosis dynamics
- Flood Risk Assessment and Management
- Enzyme Structure and Function
- Tactile and Sensory Interactions
- Virtual Reality Applications and Impacts
- Geophysics and Gravity Measurements
- Hydrological Forecasting Using AI
- MXene and MAX Phase Materials
- Advanced Memory and Neural Computing
- Electrospun Nanofibers in Biomedical Applications
- 14-3-3 protein interactions
- Climate variability and models
- Topic Modeling
- Bioactive natural compounds
- Reconstructive Surgery and Microvascular Techniques
- Microwave Engineering and Waveguides
- Morinda citrifolia extract uses
- Electrodeposition and Electroless Coatings
- Security in Wireless Sensor Networks
Chang Gung University
2013-2025
University of California, San Francisco
2020-2025
University of Rochester
2025
Taipei Veterans General Hospital
2017-2025
Neurological Surgery
2025
National Tsing Hua University
2023-2024
Yuan Ze University
2015-2024
National Cheng Kung University
2020-2024
Delft University of Technology
2024
National Central University
2024
Although the voice-sensitive neural system emerges very early in development, it has yet to be demonstrated whether neonatal brain is sensitive voice perception. We measured EEG mismatch response (MMR) elicited by emotionally spoken syllables "dada" along with correspondingly synthesized nonvocal sounds, whose fundamental frequency contours were matched, 98 full-term newborns aged 1-5 days. In Experiment 1, happy relative sounds an MMR lateralized right hemisphere. 2, fearful stronger...
Mesenchymal stem/stromal cells (MSCs) are promising potential candidates for the treatment of immunological diseases because their immunosuppressive functions. However, molecular mechanisms that mediate MSCs' activity remain elusive. In this article, we report first time, to our knowledge, secreted growth-regulated oncogene (GRO) chemokines, specifically GRO-γ, in human MSC-conditioned media have an effect on differentiation and function monocyte-derived dendritic cells. The were driven...
Hyperpolarized carbon-13 (HP-13C) MRI is a non-invasive imaging technique for probing brain metabolism, which may improve clinical cancer surveillance. This work aimed to characterize the consistency of serial HP-13C in patients undergoing treatment tumors and determine whether there evidence aberrant metabolism tumor lesion compared normal-appearing tissue. Serial dynamic HP [1-13C]pyruvate was performed on 3 healthy volunteers (6 total examinations) 5 (21 with diffuse infiltrating glioma...
The development of civilization and the preservation environmental ecosystems are strongly dependent on water resources. Typically, an insufficient supply surface resources for domestic, industrial, agricultural needs is supplemented with groundwater However, a natural resource that must accumulate over many years cannot be recovered after short period recharge. Therefore, long-term management important issue sustainable development. accurate prediction levels first step in evaluating total...
Rapid identification of peanut seed quality is crucial for public health. In this study, we present a terahertz wave imaging system using convolutional neural network (CNN) machine learning approach. Terahertz waves are capable penetrating the shell to identify peanuts without causing any damage seeds. The specificity on images investigated, and image characteristics five different qualities summarized. digitized used training testing networks, resulting in high model accuracy 98.7%...
This paper presents FacePush, a Head-Mounted Display (HMD) integrated with pulley system to generate normal forces on user's face in virtual reality (VR). The mechanism of FacePush is obtained by shifting torques provided two motors that press upon via utilization system. can varying strengths and apply those the surface face. To inform our design for noticeable discernible VR applications, we conducted studies iden- tify absolute detection threshold discrimination users' perception. After...
Understanding drought evolution and its driving factors is crucial for effective water resource management forecasting. This study enhances the analysis of probability by constructing bivariate distributions, providing a more realistic perspective than single-characteristic approaches. Additionally, meteorological migration model established to explore spatiotemporal paths related characteristics major events in Choushui River alluvial fan. The results reveal significant increase...
This study investigates the benefits of innovative full-contact insoles, crafted using polyester fabric sheets thermoplastic extruded materials, for individuals with hallux valgus-induced plantar pain. Thirty-five foot pain were randomly allocated to either experimental group, wearing insoles 6 h daily, or control regular over a period 12 weeks. Data collection occurred at baseline, and 1 week, 2 months, 3 months after initial fitting. Results indicated that significantly reduced...
<sec> <title>BACKGROUND</title> Hepatic encephalopathy (HE) accounts for a significant mortality risk in patients with liver cirrhosis. Early identification of their prognosis and incidence complications are crucial, but challenging, physicians decision making treatment strategy, especially treating non-cancer-related cirrhotic due to unpredictability disease trajectories. </sec> <title>OBJECTIVE</title> Therefore, this study aimed develop novel machine learning (ML) model enhance...
Delaying mitotic cell cycle progression has been proposed as a strategy to potentiate the effects of anti-mitotic anti-cancer drugs that induce multipolar spindles. Toward this end, we have performed an in silico docking screen targeting anaphase-promoting complex/cyclosome subunit 1 (APC1) at conserved 10-amino acid surface site was modeled interact via single hydrogen bond with essential (APC/C) co-factor division 20 (CDC20). Five molecules were identified after screening 15,000 small...
Lunar rock fragments, particularly those deemed pristine, have long been considered vital records of the Moon's formation and magmatic evolution. These fragments were thought to largely escaped intense impact history, offering a window into early lunar crust. However, concept "pristine" is increasingly debated, as traditional criteria for identifying pristine samples—based on texture, mineral content, siderophile element abundances—may overlook extensive effects reworking. In this study, we...
Abstract This study developed a new approach to produce sterile, hyperpolarized [ 13 C, 15 N 2 ]urea as novel molecular imaging probe and applied it for first-ever healthy brain volunteer studies. Hyperpolarized ]urea, small, metabolically inert molecule, offers significant advantages perfusion due its endogenous nature excellent safety profile. The methods achieved solution (132 ± 6 mM) with 27.4 5.6% polarization T 1 = 50.4 0.2 s. In studies, high-resolution C captured blood flow spatial...
Abstract Introduction: p95HER2 is the extracellular domain-truncated form of HER2 receptor while preserves intracellular tyrosine kinase activity to support tumor growth. was found in 30 40% HER2-positive breast cancer patients and associated with a more aggressive phenotype worse prognosis. Due lack domain, has been recognized as potential mechanism trastuzumab-resistance. The unmet need for trastuzumab-resistant exclusive expression cancerous tissues make an ideal therapeutic target. Here,...
T follicular helper (Tfh) cell-derived signals promote activation and proliferation of antigen-primed B cells. It remains unclear whether epigenetic regulation is involved in the cell responses to Tfh signals. Here, we demonstrate that cell-mimicking induce expression histone demethylases KDM4A KDM4C, concomitant global down-regulation their substrates, H3K9me3/me2, Depletion KDM4C potentiates response ChIP-seq de novo motif analysis reveals NF-κB p65 as a binding partner KDM4C. Their...
Paclitaxel induces multipolar spindles at clinically relevant doses but does not substantially increase mitotic indices. Paclitaxel's anti-cancer effects are hypothesized to occur by promoting chromosome mis-segregation on leading apoptosis, necrosis and cyclic-GMP-AMP Synthase-Stimulator of Interferon Genes (cGAS-STING) pathway activation in daughter cells, secretion type I interferon (IFN) immunogenic cell death. Eribulin vinorelbine have also been reported cause increases cancer cells....
Flood disasters often result in significant losses of life and property, making them among the most devastating natural hazards. Therefore, reliable accurate water level forecasting is critically important. Rainfall-runoff modeling, which a complex nonlinear time series process, plays key role this endeavor. Numerous studies have demonstrated that data-driven methods, particularly deep learning approaches such as convolutional neural networks (CNNs), long short-term memory (LSTM) networks,...
Hydrogels provide three-dimensional (3D) frames with tissue-like elasticity and high water content for tissue scaffolds. Previously, we reported the design synthesis protocol of a biodegradable poly(carboxybetaine) poly(CB) hydrogel zwitterionic carboxybetaine methacrylate (CBMA) monomer disulfide-containing crosslinker via free radical polymerization. We also demonstrated that cells could be successfully encapsulated in hydrogels without compromising cytoviability. In this study, evaluated...
For the first time, two-layer stacked nanowire gate-all-around (GAA) negative capacitance (NC) field-effect transistors (FETs) with an ultrasmall poly-Si channel that has a size of 5.3 × 9 nm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and metal-ferroelectric-metal-insulator-semiconductor (MFMIS) are experimentally demonstrated. FETs exhibit remarkable I <sub xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> -I...
In this article, we successfully fabricated nanowire (NW) negative capacitance (NC)-related ferroelectric FETs (FE-FETs) with two structures: trigate (TG) and gate-all-around (GAA). Planar capacitors a metal-FE-metal (MFM) structure were investigated first. Post-metal annealing (PMA) at 700 °C resulted in the best ferroelectricity. This condition was considerably different from that of directly stacking onto NWs because difference size curvature between planar TG or GAA structures. Because...
We present HMD Light, a proof-of-concept Head-Mounted Display (HMD) implementation that reveals the Virtual Reality (VR) user's experience in physical environment to facilitate communication between VR and external users mobile context. While previous work externalized through an on-HMD display, Light places display into enable larger interaction area. This explores design space of presents four applications demonstrate its versatility. Our exploratory user study observed participant pairs...
This study compared the antinociceptive and anti-inflammatory effects of various parts Broussonetia papyrifera (L.) L'Herit. ex Vent. (BP, Moraceae) by chemical-induced pain inflammation in rodents. All BP (1 2 g/kg, p.o.) effectively inhibited writhing responses induced 1% acetic acid. The radix, leaf, fruit late-phase licking caused formalin. But only radix reduced edema carrageenan at 1–2 h. Furthermore, abdominal Evan's blue extravasations inflammatory mediators, including serotonin...