A5035688016- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- Enzyme Structure and Function
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Atomic and Subatomic Physics Research
- Glioma Diagnosis and Treatment
- Electron Spin Resonance Studies
- Nanoplatforms for cancer theranostics
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- NMR spectroscopy and applications
- Virus-based gene therapy research
- Amino Acid Enzymes and Metabolism
- CAR-T cell therapy research
- Advanced Radiotherapy Techniques
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Ultrasound and Hyperthermia Applications
University of California System
2024-2025
University of California, San Francisco
2022-2025
University of California, Berkeley
2022-2025
Wake Forest University
2019-2021
Memorial Sloan Kettering Cancer Center
2020
Atrium Health Wake Forest Baptist
2019
Hyperpolarized 13 C MRI quantitatively measures enzyme-catalyzed metabolism in cancer and metabolic diseases. Whole-abdomen imaging will permit dynamic of several abdominal organs simultaneously healthy diseased subjects.Image hyperpolarized [1-13 C]pyruvate products the abdomens volunteers, overcoming challenges motion, magnetic field variations, spatial coverage. Compare across volunteers.Prospective technical development.A total volunteers (8 male), 21-64 years (median 36).A 3 T. Proton:...
Abstract Purpose Accurate quantification of metabolism in hyperpolarized (HP) 13 C MRI is essential for clinical applications. However, kinetic model parameters are often confounded by uncertainties radiofrequency flip angles and other parameters. Methods A data‐driven fitting approach HP C‐pyruvate was proposed that compensates the B 1 + field. We hypothesized introducing a scaling factor to angle minimize fit residuals would allow more accurate determination pyruvate‐to‐lactate conversion...
Abstract This study developed a new approach to produce sterile, hyperpolarized [ 13 C, 15 N 2 ]urea as novel molecular imaging probe and applied it for first-ever healthy brain volunteer studies. Hyperpolarized ]urea, small, metabolically inert molecule, offers significant advantages perfusion due its endogenous nature excellent safety profile. The methods achieved solution (132 ± 6 mM) with 27.4 5.6% polarization T 1 = 50.4 0.2 s. In studies, high-resolution C captured blood flow spatial...
To enhance human prostate-specific membrane antigen (hPSMA)-specific chimeric receptor (CAR) T cell therapy in a hPSMA
Background Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer‐related death in United States. However, early response assessment using current approach measuring changes tumor size on computed tomography (CT) or MRI challenging. Purpose To investigate feasibility hyperpolarized (HP) [1‐ 13 C]pyruvate to quantify metabolism normal appearing pancreas and PDA, assess PDA following systemic chemotherapy. Study Type Prospective. Subjects Six patients (65.0 ± 7.6 years, 2...
Stereotactic radiosurgery (SRS) is used for local control treatment of patients with intracranial metastases. As a result SRS, some develop radiation-induced necrosis. Radiographically, necrosis can appear similar to tumor recurrence in magnetic resonance (MR) T1 -weighted contrast-enhanced imaging, T2 MR and Fluid-Attenuated Inversion Recovery (FLAIR) imaging. Radiographic ambiguities often necessitate invasive brain biopsies determine lesion etiology or cause delayed subsequent therapy...
The efficacy of an imaging-driven mechanistic biophysical model tumor growth for distinguishing radiation necrosis from progression in patients with enhancing lesions following stereotactic radiosurgery (SRS) brain metastasis is validated.We retrospectively assessed the using 73 78 and histologically confirmed or progression. Postcontrast T1-weighted MRI images were used to extract parameters a reaction-diffusion logistic mechanically coupled surrounding tissue. resulting was then estimate...
Abstract Purpose Improving the quality and maintaining fidelity of large coverage abdominal hyperpolarized (HP) 13 C MRI studies with a patch based global–local higher‐order singular value decomposition (GL‐HOVSD) spatiotemporal denoising approach. Methods Denoising performance was first evaluated using simulated [1‐ C]pyruvate dynamics at different noise levels to determine optimal k global local parameters. The GL‐HOSVD method optimized parameters then applied two HP EPI human cohorts ( n...
e15059 Background: Hyperpolarized 13 C (HP C) MRI is a novel molecular imaging approach that detects aberrant aerobic metabolism, namely elevated rates of pyruvate-to-lactate conversion (k PL ), in patients with advanced malignancies. Higher k has been shown to correlate higher tumor grade among localized prostate cancer (PC). This research sought evaluate the correlation between and clinical outcome measures PC. Methods: Patients metastatic or locally PC (castration sensitive resistant)...
[13C,15N2]urea and [1-13C]pyruvate were polarized together using dynamic nuclear polarization simultaneously injected into healthy volunteers for simultaneous imaging of metabolism perfusion in the abdomen. Whole-abdomen images successfully obtained distribution urea was compared to pyruvate its metabolites. While relative intensity various organs similar between pyruvate, temporal courses different. This represents first use co-polarized human abdomen, will be a powerful potential tool...
Whole-abdomen imaging with hyperpolarized 13C is challenging due to B0 and B1 inhomogeneities, respiratory motion, broad spatial coverage. There also little baseline data about healthy metabolism in abdominal organs. We developed describe here a reliable method overcome these challenges, enabling metabolic of the entire abdomen series volunteers. present observed conversation rates HP [1-13C]pyruvate lactate alanine key organs such as liver, kidneys, pancreas, spleen. Methods established set...
A substantial challenge in hyperpolarized (HP) 13C MRI is the limited signal-to-noise ratio (SNR) of downstream metabolites, which restricts achievable spatial resolution. To overcome this for large coverage abdominal studies, a patch-based spatiotemporal denoising approach was applied to denoise dynamic imaging data [1-13C]pyruvate echo-planar (EPI) human datasets. With denoising, 11.4 ± 1.8 and 8.7 2.4 fold sensitivity gain achieved [1-13C]alanine [1-13C]lactate, along with improved...
Motivation: Monitoring the progression or response of advanced prostate metastases is a current clinical unmet need that not reliably delineated with CT and PET. Goal(s): Here, we developed high-resolution whole abdominopelvic [1-13C]pyruvate HP MRI approach for metabolic biomarker characterization in cancer patients. Approach: A variable-resolution imaging was used to provide [1-13C]pyruvate, robust spatiotemporal denoising B1+ variation correction methods were quantify rate-constant...
Motivation: Hyperpolarized (HP) 13C-pyruvate MRI can address limitations of PSMA-PET for monitoring therapy and evaluating treatment-emergent, lethal subtypes prostate cancer. Goal(s): To establish characterize a novel radiomics framework tumor metabolism in advanced cancer based on whole abdominopelvic HP MRI. Approach: We extracted 316 metabolic features from 16 patients. Following feature selection classification, their prognostic values were evaluated using uni- multivariate survival...
Motivation: Accurate quantification of metabolism in hyperpolarized (HP) 13C MRI is essential for clinical application. However, kinetic model parameters such as flip angle are often uncertain, leading to mismatch. Goal(s): We aimed develop a data-driven approach quantify the HP pyruvate-to-lactate conversion rate (kPL) with improved accuracy. Approach: To validate our method, we conducted numerical simulations and animal studies 13C-pyruvate applied this method human abdominal data....
2-deoxy-d-glucose (2-DG) is a glucose analog widely used in FDG-PET imaging as biological tracer of uptake. This study innovatively redirects its application 2 H NMR by using deuterated version 2-DG (2-DG-d2) and explores potential mapping uptake without ionizing radiation. A workflow described here regarding multi-band RF pulse design bSSFP sequence optimization, which enables rapid with high sensitivity. Both vitro vivo results have validated the sequence’s specificity...