A5100450546- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- Electron Spin Resonance Studies
- Atomic and Subatomic Physics Research
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Enzyme Structure and Function
- Spectroscopy and Chemometric Analyses
- Synthetic Organic Chemistry Methods
- Lanthanide and Transition Metal Complexes
- Asymmetric Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Catalytic Alkyne Reactions
- Synthesis and Catalytic Reactions
- Supramolecular Chemistry and Complexes
- Supramolecular Self-Assembly in Materials
- Synthesis and biological activity
- Nuclear Physics and Applications
- Solid-state spectroscopy and crystallography
- Metal-Organic Frameworks: Synthesis and Applications
- Water Quality Monitoring and Analysis
- Multicomponent Synthesis of Heterocycles
- Financial Markets and Investment Strategies
- Banking stability, regulation, efficiency
University of California System
2024-2025
University of California, San Francisco
2022-2025
Hebei University of Technology
2025
Bank for International Settlements
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Institute of Scientific and Technical Information
2013-2023
University of Hong Kong
2017-2023
Keio University
2021
Chinese University of Hong Kong
2018-2020
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2020
Hyperpolarized 13 C MRI quantitatively measures enzyme-catalyzed metabolism in cancer and metabolic diseases. Whole-abdomen imaging will permit dynamic of several abdominal organs simultaneously healthy diseased subjects.Image hyperpolarized [1-13 C]pyruvate products the abdomens volunteers, overcoming challenges motion, magnetic field variations, spatial coverage. Compare across volunteers.Prospective technical development.A total volunteers (8 male), 21-64 years (median 36).A 3 T. Proton:...
This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with metabolite-specific gradient echo (GRE) sequence for pyruvate metabolic products, improving SNR spatial resolution first hyperpolarized 13 C-MRI human injection co-hyperpolarized [1-13 C]pyruvate [13 C,15 N2 ]urea.A bSSFP imaging was designed using urea-specific excitation pulse, optimized TR, readouts. Simulations phantom...
Abstract Purpose This study aimed to develop a new high‐resolution MRI sequence for the imaging of ultra‐short transverse relaxation time (uT 2 ) components in brain, while simultaneously providing proton density (PD) contrast reference and quantification. Theory The combines low flip angle balanced SSFP (bSSFP) UTE techniques, together with 3D dual‐echo rosette k‐space trajectory readout. Methods expected image was evaluated by simulations. A cohort six healthy volunteers eight multiple...
Abstract Purpose In this work, we adopt the MR fingerprinting (MRF) framework and leverage its flexibility in quantitative pulse sequence design to propose improved balanced steady‐state free precession (bSSFP)–based hyperpolarized Carbon‐13 ( 13 C) acquisitions for robust metabolic conversion rate quantification. Methods Spectrally selective bSSFP‐based with variable RF excitation were implemented [1‐ C]pyruvate used conjunction prior implementation of C]lactate bSSFP imaging. MRF parameter...
Create vendor-neutral modular sequences for X-nuclear acquisitions and build an X-nuclear-enabled Pulseq interpreter GE (GE HealthCare, Waukesha, WI) scanners. We designed a 2D gradient echo spiral sequence to support several formats metabolite-specific 3D balanced steady-state free precession hyperpolarized (HP) carbon-13 (13C) MRI. In addition, we developed new scanners, named TOPPE MNS (TOPPE Multi-Nuclear Spectroscopy), implement capabilities. evaluated the through phantom studies using...
Chirality-assisted synthesis (CAS) is a general approach to control the shapes of large molecular strips. CAS based on enantiomerically pure building blocks that are designed strictly couple in single geometric orientation. Fully shape-persistent structures can thus be created, even form linear chains. With CAS, selective recognition between host and guest molecules reliably de novo. To demonstrate this concept, three C-shaped strips embrace pillar[5]arene macrocycle were synthesized. The...
Abstract Purpose Metabolite‐specific balanced SSFP (MS‐bSSFP) sequences are increasingly used in hyperpolarized [1‐ 13 C]Pyruvate (HP C) MRI studies as they improve SNR by refocusing the magnetization each TR. Currently, pharmacokinetic models to fit conversion rate constants, k PL and PB , constant maps do not account for differences signal evolution of MS‐bSSFP acquisitions. Methods In this work, a flexible model was built that can be constants these experiments. The validated vivo using...
The stereoselective synthesis of a diverse set functionalized indolizidine systems has been accomplished through the aza-Prins cyclization 2-allylpyrrolidines. condensation aldehydes onto 2-allylpyrrolidines yields iminium ions that undergo highly diastereoselective cyclization, producing up to two stereogenic centers and new rings in one step.
Solid tumors such as prostate cancer (PCa) commonly develop an acidic microenvironment with pH 6.5-7.2, owing to heterogeneous perfusion, high metabolic activity, and rapid cell proliferation. In preclinical models, disease progression is associated a decrease in tumor extracellular pH, suggesting that imaging may reflect biomarker detect aggressive high-risk disease. Therefore, we developed hyperpolarized carbon-13 MRI method image the (pHe) prepared it for clinical translation detection...
The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) 13C-pyruvate MRI a promising new tool for non-invasive quantification of glycolytic Krebs cycle flux. However, human studies HP 13C-MRI have yet to demonstrate regional metabolism, important in HCM patients with asymmetric septal/apical hypertrophy. We developed applied methods whole-heart imaging 13C-pyruvate,...
Purpose Three‐dimensional (3D) multiplexed sensitivity encoding and reconstruction (3D‐MUSER) algorithm is proposed to reduce aliasing artifacts signal corruption caused by inter‐shot 3D phase variations in diffusion‐weighted echo planar imaging (DW‐EPI). Theory Methods 3D‐MUSER extends the original framework of (MUSE) a hybrid k‐space‐based reconstruction, thereby enabling correction variations. A single‐shot EPI navigator was used measure The performance evaluated analyses point‐spread...
Abstract Chirality‐assisted synthesis (CAS) is a general approach to control the shapes of large molecular strips. CAS based on enantiomerically pure building blocks that are designed strictly couple in single geometric orientation. Fully shape‐persistent structures can thus be created, even form linear chains. With CAS, selective recognition between host and guest molecules reliably de novo. To demonstrate this concept, three C‐shaped strips embrace pillar[5]arene macrocycle were...
Mutual funds investing illiquid corporate bonds actively manage Treasury positions to buffer redemption shocks. We argue and show that this liquidity management practice can transmit concentrate non-fundamental fund flow shocks onto the Treasuries hold, generating price pressure fragility for Treasuries. held more by bond tend exhibit high return comovement during downside markets, left-skewed returns, frequent co-jumps, compared with low ownership. address endogeneity concerns exploiting...
Abstract The naturally occurring quercetin flavonoid, dihydroquercetin, is widely distributed in plant tissues and has a variety of biological activities. Herein, magnetic molecularly imprinted solid‐phase extraction was tailor made for selective determination dihydroquercetin Larix griffithiana using high‐performance liquid chromatography. Amino‐functionalized core‐shell nanoparticles were prepared characterized scanning electron microscopy, transmission vibrating sample magnetometry,...
BACKGROUND: Kidney transplant is the treatment of choice for patients with end-stage renal disease. Early detection allograft injury important to delay or prevent irreversible damage. PURPOSE: To investigate feasibility hyperpolarized (HP) [1-13C]pyruvate MRI assessing kidney metabolism. SUBJECTS: 6 participants (mean age, 45.2 +- 12.4 years, 2 females) scheduled biopsy and 5 59.6 10.4 cell carcinoma (RCC). ASSESSMENT: Five six underwent after MRI. Estimated glomerular filtration rate (eGFR)...
Abstract Mutual funds investing in illiquid corporate bonds actively manage Treasury positions to buffer redemption shocks. This liquidity management practice can transmit non-fundamental fund flow shocks onto Treasuries, generating excess return volatility. Consistent with this hypothesis, we find that volatility is positively associated bond ownership, and pattern more pronounced among conducting intensive management. Causal evidence provided by exploiting the U.S. Securities Exchange...
Purpose: To enable 2D Nyquist ghost correction for multi-band interleaved echo-planar imaging (EPI) without reference scan. Methods: phase errors between positive and negative echo were directly measured from the EPI data acquired with alternating readout polarity, then corrected by using multiplexed sensitivity encoding (MUSE) framework. The proposed method was tested on brain under different multi-shot factors (4, 8, 16). In addition, corrections zoomed-FOV, reduced-FOV, or 3D also...
The first examples of azomethine ylides derived from allylic amine and glyoxal precursors are reported. condensation primary α-aryl amines with glyoxylates or glyoxals affords conjugated that undergo facile [3 + 2] cycloaddition, providing 5-alkenyl pyrrolidine cycloadducts cannot be accessed through the classical use amino esters as ylide precursors.