A5100374973- Pharmacological Effects of Natural Compounds
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Traditional Chinese Medicine Analysis
- Ginger and Zingiberaceae research
- Metabolomics and Mass Spectrometry Studies
- Plant-based Medicinal Research
- Pharmacogenetics and Drug Metabolism
- Medicinal Plant Pharmacodynamics Research
- Drug-Induced Hepatotoxicity and Protection
- Glycosylation and Glycoproteins Research
- Medicinal Plants and Bioactive Compounds
- Advanced MRI Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
- Phytochemicals and Medicinal Plants
- Microbial Natural Products and Biosynthesis
- Advanced biosensing and bioanalysis techniques
- Advanced NMR Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Drug Transport and Resistance Mechanisms
- Microbial Community Ecology and Physiology
- Plant Pathogens and Fungal Diseases
- Nicotinic Acetylcholine Receptors Study
China Pharmaceutical University
2025
Dalian Institute of Chemical Physics
2013-2024
Chinese Academy of Sciences
2013-2024
Dalian Medical University
2013-2024
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Sun Yat-sen University
2023-2024
Mongolian National University
2023
Shanghai University
2023
Hunan University of Traditional Chinese Medicine
2023
Southwest University of Science and Technology
2023
Ginger, the rhizome of plant Zingiber officinale , has received extensive attention because its antioxidant, anti-inflammatory, and antitumor activities. Most researchers have considered gingerols as active principles paid little to shogaols, dehydration products corresponding during storage or thermal processing. In this study, we purified identified eight major components, including three from ginger extract compared their anticarcinogenic anti-inflammatory Our results showed that shogaols...
Breast cancer metastasis is the main cause of death in women, so far, no effective treatment has inhibited breast metastasis. Sulforaphane (SFN), a natural compound derived from broccoli, shown potential health benefits many cancers. However, research on still insufficient. Here, we showed that SFN, including its two isomers R-SFN and S-SFN, significantly TGF-β1-induced migration invasion cells. Proteomic phosphoproteomic analysis SFN affected formation cytoskeleton. Subsequent experiments...
Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views ENM-induced bio-effects. Here we report a multi-hierarchical nano-SAR assessment for representative ENM, Fe2O3, by metabolomics proteomics analyses. The established profile allows visualizing...
Dihydromyricetin (DMY) has recently attracted increased interest due to its considerable health-promoting activities but there are few reports on antibacterial activity and mechanism. In this paper, the mechanisms of DMY from Ampelopsis grossedentata leaves against food-borne bacteria investigated. Moreover, effects pH, thermal-processing, metal ions also evaluated. The results show that exhibits ideal five types (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella...
Although glycoproteomics is greatly developed in recent years, our knowledge about N-glycoproteome of human tissues still very limited. In this study, we comprehensively mapped the N-glycosylation sites liver by combining click maltose-hydrophilic interaction chromatography (HILIC) and improved hydrazide chemistry. The specificity could be as high 90% for chemistry 80% HILIC. Altogether, identified 14,480 N-glycopeptides matched with N-!P-[S|T|C] sequence motif from liver, corresponding to...
Abstract A new member of the CYP116B subfamily—P450 La MO —was discovered in Labrenzia aggregata by genomic data mining. It was successfully overexpressed Escherichia coli , purified, and subsequently characterized spectroscopically, its catalytic properties were assessed. Substrate profiling P450 revealed that it a versatile catalyst, exhibiting hydroxylation epoxidation activities as well O ‐dealkylation asymmetric sulfoxidation activities. Diverse compounds, including alkylbenzenes,...
Solar ultraviolet B (UVB) radiation is known to trigger inflammation, oxidative stress and apoptotic responses through various signaling pathways, which eventually lead skin cancer. The present study investigated whether liquiritin suppresses UVB‑induced injury in vivo vitro using SKH‑1 hairless mice HACAT cells, respectively. animals were exposed UVB irradiation (180 mJ/cm2) for 20 min, followed by treatment. findings indicated that exposure resulted the excessive release of...
The weak inherent non-covalent interactions between carbon aerogel backbone nanoparticles obtained by the pyrolysis of conventional organic can lead to poor mechanical properties. When applied in thermal protection system a high-speed spacecraft, preparation insulation materials with excellent formability and high strength still remains huge challenge. This work reports an efficient approach for fabricating foam-reinforced composites compounding nanoporous polyimide into microporous...
Despite the importance of protein N-glycosylation in a series biological processes, in-depth characterization glycosylation is still challenge due to high complexity samples and lacking highly sensitive detection technologies. We developed monolithic capillary column based glycoproteomic reactor enabling high-sensitive mapping sites from minute amounts sample. Unlike conventional proteomic reactors with only strong-cation exchange or hydrophilic-interaction chromatography columns, this novel...
Background/Aims: Uncaria rhynchophylla, known as “Gou-teng”, is a traditional Chinese medicine (TCM) used to extinguish wind, clear heat, arrest convulsions, and pacify the liver. Although U. rhynchophylla has long history of being often treat central nervous system (CNS) diseases, its efficacy potential mechanism are still uncertain. This study investigated neuroprotective effect underlying extract (URE) in MPP+-induced SH-SY5Y cells MPTP-induced mice. Methods: mice were established...
Background and Aim: QingXiaoWuWei Decoction (QXWWD) is a traditional Chinese medicine that commonly used in clinical settings to treat inflammatory bacterial diseases. However, there still lot learn about its molecular mechanism. A network pharmacology approach was applied investigate the pharmacological mechanisms of QXWWD inflammation treatment. Methods: The basic involved anti-inflammatory antibacterial potentials were identified using docking. principal components by HPLC-Q-Exactive-MS...
Development of new effective antimicrobial drugs is still a big challenge to date due microbial infection remains an inevitable problem against human health. In this study, fatty acids extract Lucilia sericata larvae (LFAs) was obtained and evaluated by gas chromatograph-mass spectrometry (GC-MS), its antibacterial activity Staphylococcus aureus (S. aureus) Streptococcus pneumoniae pneumoniae) investigated. We found that LFAs exhibited S. with minimal inhibitory concentrations (MICs) 125...
Objective This study aimed to explore the differences between Eucommiae cortex (EC) endophytic bacteria from different origins and their effects on active ingredients of EC. Methods A total 10 samples Eucommia ulmoides Oliv. ( E. ) bark were collected each following four regions, namely, Zunyi in Guizhou (GZ), Baokang Hubei (HUB), Cili Hunan (HUN), Loyang Shaanxi (SX). Subsequently, contents main EC determined by ultra-performance liquid chromatography (UPLC), detected 16S rRNA sequencing....
The fruit of Terminalia chebula Retz., or Tibet Olive, is widely used as a food supplement in China. It possesses some natural antimicrobial properties; however, its chemical composition and antivirulence effects have not been identified. In this work, 29 compounds were identified from the peel T. by ultra-high-performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry. Both extract phenolic acid, corilagin, showed antivirulent activity against Staphylococcus...
As a star insulation material, aerogel plays significant role in saving energy and meeting temperature requirements industry due to its extremely low thermal conductivity. The prediction of aerogel's conductivity is great interest both research industry, particularly because the difficulty measuring separated gas conductivities directly by experiment. Hence, proportions conduction solid-gas coupling are debatable. In this work, molecular dynamics simulations were performed on porous silica...
Intestinal ischemia/reperfusion (II/R) injury is a common pathological process with high clinical morbidity and mortality. Autophagy plays an important role in the development of II/R. Corilagin (CA) natural ellagitannin various pharmacological effects such as autophagy regulation, antioxidant, antiapoptosis. However, whether CA alleviates II/R still unclear. In this study, we had found that significantly attenuated induced intestinal tissue damage, oxidative stress, cell apoptosis rats....
Qingyi decoction (QYD) has anti-inflammatory pharmacological properties and substantial therapeutic benefits on severe acute pancreatitis (SAP) in clinical practice. However, its protective mechanism against SAP-associated lung injury (ALI) remains unclear. In this study, we screened the active ingredients of QYD from perspective network pharmacology to identify core targets signaling pathways ALI. Rescue experiments were used determine relationship between ferroptosis. Then, metabolomics...
Abstract Herein, we report CO 2 ‐mediated metathesis reactions between amines and DMF to synthesize formamides. More than 20 amines, including primary, secondary, aromatic, heterocyclic diamines, amino acids, are converted the corresponding formamides with good‐to‐excellent conversions selectivities under mild conditions. This strategy employs as a mediator activate amine metal‐free The experimental data in situ NMR attenuated total reflectance IR spectroscopy measurements support formation...