A5058938740- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug Transport and Resistance Mechanisms
- Barrier Structure and Function Studies
- Traditional Chinese Medicine Analysis
- Ginkgo biloba and Cashew Applications
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Rheumatoid Arthritis Research and Therapies
- Gout, Hyperuricemia, Uric Acid
- Natural product bioactivities and synthesis
- Cancer therapeutics and mechanisms
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Immune Response and Inflammation
- Attention Deficit Hyperactivity Disorder
- Extracellular vesicles in disease
- NF-κB Signaling Pathways
- Pharmaceutical studies and practices
- Melanoma and MAPK Pathways
- Salivary Gland Disorders and Functions
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmacological Effects and Toxicity Studies
China Pharmaceutical University
2016-2025
State Key Laboratory of Natural Medicine
2019
Stanford University
2018
Inner Mongolia Medical University
2013
Capital Medical University
2013
First Affiliated Hospital of Wannan Medical College
2013
Zhengzhou University
2013
Jiangsu University of Science and Technology
2008-2009
Rationale: Peripheral blood monocytes are recruited into the ischemic brain and transform macrophages after stroke.Nevertheless, exact role of CCR2-dependent monocytes/ in injury stroke remains elusive.Methods: We used CCR2 knockout (KO) mice pharmacological inhibitor, propagermanium (PG), to address monocytes/macrophages acute stage neurological functional recovery middle cerebral artery (MCA) occlusion reperfusion.Results: KO resulted smaller infarct size lower mortality than wild type...
P-glycoprotein (P-gp) is expressed on brain microvessel endothelial cells of blood-brain barrier (BBB) and elevated after cerebral ischemia. In this study, we explored the influence potential mechanisms P-gp BBB function in experimental ischemic stroke vivo vitro. Middle artery occlusion/reperfusion (MCAO/R) was created mice. Oxygen-glucose deprivation/reoxygenation (OGD/R) performed microvascular vessel-derived (bEnd.3) to mimic ischemia/reperfusion injury P-gp-specific siRNA...
Antimicrotubulin chemotherapeutic agents, including plant-derived vincaalkaloids such as vincristine, can cause peripheral neuropathic pain. Exogenously activated heme oxygenase 1 (HO-1) is a potential therapy for chemotherapy-induced neuroinflammation. In this study, we investigated role Nrf2/HO-1/CO in mediating vincristine-induced neuroinflammation by inhibiting connexin 43 (Cx43) production the spinal cord following intrathecal application of HO-1 inducer protoporphyrin IX cobalt...
Ma Xing Shi Gan Decoction (MXD), a classical traditional Chinese medicine prescription, is widely used for the treatment of upper respiratory tract infection. However, effect MXD against particulate matters with diameter less than 2.5 μm (PM2.5) induced lung injury remains to be elucidated. In this study, rats were stimulated PM2.5 induce injury. was given orally once daily five days. Lung tissues harvested assess pathological changes and edema. Myeloperoxidase (MPO) activity malonaldehyde...
Hyperlipidemia aggravates myocardial ischemia/reperfusion (MI/R) injury through stimulating excessive inflammatory response. Therefore, blockade of signal is a potential therapeutic management for MI/R complicated with hyperlipidemia. Hydroxysafflor yellow A (HSYA, monomer extracted from Carthamus tinctorius L.), was studied in this article to address that the regulation would alleviate combined hyperlipidemia injury. High-fat diet induced worsened mediated heart (elevation infarct size,...