A5103242557- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Thermoregulation and physiological responses
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Aortic aneurysm repair treatments
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Infrared Thermography in Medicine
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Peripheral Artery Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Cancer, Lipids, and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
Kagoshima University
2015-2024
Kagoshima City Hospital
2005-2023
Tohoku University
2008-2020
Daiichi-Sankyo (Japan)
2020
University of Shizuoka
2020
Kagoshima University Hospital
2016-2017
Massachusetts General Hospital
2006
Kyushu Hospital
1996
Keio University
1989-1995
Sumitomo Hospital
1976
Mutations of mitochondrial DNA have been demonstrated as causes human diseases. While these disorders typically involve multiple organs, the effect mutations on heart has not systematically studied.We studied and cardiac changes in 17 patients with Kearns-Sayre syndrome; ocular myopathy; myoclonus epilepsy ragged red fibers (MERRF); myopathy, encephalopathy, lactic acidosis, strokelike episodes (MELAS). Cardiac involvement was evaluated by chest radiograph, ECG, His-bundle electrogram,...
Background— Surgical annuloplasty can potentially hoist the posterior annulus anteriorly, exaggerate leaflet (PML) tethering, and lead to recurrent ischemic/functional mitral regurgitation (MR). Characteristics of configurations in late postoperative MR were investigated. Methods Results— In 30 patients with surgical for ischemic 20 controls, anterior (AML) PML tethering angles relative line connecting annuli, apical displacement coaptation grade measured by echocardiography before, early...
Background The brachial - ankle pulse wave velocity (baPWV) is used to evaluate the degree of atherosclerosis and arterial distensibility, but its major limitation that it affected by changes in blood pressure (BP) during measurement. Recently, a new atherosclerotic index, cardio-ankle vascular index (CAVI), has been developed measuring PWV BP. CAVI adjusted for BP based on stiffness parameter β should measure independent purpose this study was validity compared with baPWV, reproducibility...
Rationale: Peripheral blood monocytes are recruited into the ischemic brain and transform macrophages after stroke.Nevertheless, exact role of CCR2-dependent monocytes/ in injury stroke remains elusive.Methods: We used CCR2 knockout (KO) mice pharmacological inhibitor, propagermanium (PG), to address monocytes/macrophages acute stage neurological functional recovery middle cerebral artery (MCA) occlusion reperfusion.Results: KO resulted smaller infarct size lower mortality than wild type...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are reported to have BP-lowering effect in addition blood glucose-lowering effect, however, its mechanism is still unknown. This study aimed investigate the of pressure (BP) lowering effects SGLT2 using 24-h urinary collection obese type diabetes patients. Twenty patients with (age 48.2 ± 10.7 years, BMI 33.0 4.9 kg/m2) were enrolled. Urine volume, glucose and sodium excretion, BP at baseline weeks 6 months after administration measured. Body...
Background The aim of the present study was to determine whether repeated 60C sauna treatment improves cardiac arrhythmias in chronic heart failure (CHF) patients, because ventricular are an important therapeutic target CHF. Methods and Results Thirty patients (59±3 years) with New York Heart Association functional class II or III CHF at least 200 premature contractions (PVCs)/24 h assessed by 24-h Holter recordings were studied. They randomized into sauna-treated (n=20) non-treated (n=10)...
Background Nitric oxide (NO), constitutively produced by endothelial NO synthase (eNOS), plays roles in angiogenesis. Having reported that thermal therapy up-regulated the expression of arterial eNOS hamsters, we investigated whether this increased angiogenesis mice with hindlimb ischemia. Methods and Results Unilateral ischemia was induced apolipoprotein E-deficient mice, which were divided into control groups. The latter placed a far-infrared dry sauna at 41°C for 15 min then 34°C 20 once...
The brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) are used to evaluate arterial distensibility. purpose of this study was elucidate the acute chronic effects smoking on stiffness as measured by baPWV CAVI. Ten male smokers were studied effect stiffness. To stiffness, 160 active analyzed. CAVI calculated measuring volume record, blood pressure (BP), length from heart ankle. using a VaSera VS-1000. In study, increased immediately after 1 cigarette....
We examined the pathogenic significance of VEGF (vascular endothelial growth factor)-A in experimental abdominal aortic aneurysms (AAAs) and translational value pharmacological VEGF-A or its receptor inhibition aneurysm suppression. Approaches Results: AAAs were created male C57BL/6J mice via intra-aortic elastase infusion. Soluble VEGFR (VEGF receptor)-2 extracellular ligand-binding domain (delivered Ad [adenovirus]-VEGFR-2), anti-VEGF-A mAb (monoclonal antibody), sunitinib used to...
Vascular endothelial dysfunction is involved in the pathophysiology of chronic heart failure (CHF). It has been reported that sauna therapy, which allows thermal vasodilation, improves vascular patients with CHF. The present study investigates mechanisms through therapy induced by CHF.Normal control and male TO-2 cardiomyopathic hamsters were used. Thirty-week-old treated daily an experimental far infrared-ray dry system for 15 min at 39 degrees C followed 20 30 C. This procedure raised...
Background Cerebral microthromboembolism after atrial fibrillation (AF) ablation has been reported in 4–20% with perioperative warfarin. Dabigatran is a new anticoagulant patients nonvalvular AF. We investigated the incidence of asymptomatic cerebral AF warfarin or dabigatran using diffusion‐weighted and T2‐weighted magnetic resonance imaging (MRI). Methods Results Our study included 210 consecutive (111 paroxysmal 99 persistent) who underwent complex fractionated electrogram‐guided...
Background:Waon therapy improves heart failure (HF) symptoms, but further evidence in patients with advanced HF remains uncertain.Methods and Results:In 19 institutes, we prospectively enrolled hospitalized HF, who had plasma levels of B-type natriuretic peptide (BNP) >500 pg/ml on admission BNP >300 regardless more than 1 week medical therapy. Enrolled were randomized into Waon or control groups. was performed once daily for 10 days a far infrared-ray dry sauna maintained at 60℃ 15 min,...
Aim: Low-density lipoprotein cholesterol (LDL-C) is routinely estimated using the Friedewald equation [LDL-C(F)]. A novel method for LDL-C [LDL-C(M)] estimation recently proposed by Martin et al. was reported to be more accurate than formula in subjects United States. The validity of LDL-C(M) different races and patients with diabetes mellitus (DM) has not been elucidated. purpose this study validate estimates Japanese population type 2 DM comparing LDL-C(F) directly measured [LDL-C(D)].
We have reported that repeated sauna therapy improves impaired vascular endothelial function in a patient with coronary risk factors. hypothesized decreases urinary 8-epi-prostaglandin F2α (PGF2α) levels as marker of oxidative stress and conducted randomized, controlled study. Twenty-eight patients at least one factor were divided into group (n = 14) non-sauna 14). Sauna was performed 60°C far infrared-ray dry for 15 minutes then bed rest blanket 30 once day two weeks. Systolic blood...
Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease, although it has yet to be established whether CKD independent factor for arterial stiffness in community residents. The purpose this study was determine the correlation between cardio-ankle vascular index (CAVI) and estimated glomerular filtration rate (eGFR) general population.We studied 881 consecutively enrolled subjects undergoing health checkups. CAVI calculated automatically from pulse volume...
A previous report by our team showed that Waon therapy, using a far infrared-ray dry sauna at 60°C, improves cardiac and vascular function in patients with chronic heart failure (CHF). The purpose of the present study was to clarify effect therapy on oxidative stress CHF investigate its mechanism animal experiments.Forty were divided into control (n=20) groups. All received standard optimal medications for CHF. group treated daily 4 weeks. After weeks concentrations hydroperoxide brain...
Background:The association between serum uric acid (UA) levels and atrial fibrillation (AF) in the general population Japan is not well known.