A5103167696- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Gynecological conditions and treatments
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Prenatal Screening and Diagnostics
- Systemic Sclerosis and Related Diseases
- Oral Health Pathology and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal Diseases and Glomerulopathies
- Dermatologic Treatments and Research
- Uterine Myomas and Treatments
- Sperm and Testicular Function
- Birth, Development, and Health
- Cytomegalovirus and herpesvirus research
- Intestinal and Peritoneal Adhesions
- Endometrial and Cervical Cancer Treatments
- Acne and Rosacea Treatments and Effects
- Congenital Anomalies and Fetal Surgery
- Mycobacterium research and diagnosis
Zhejiang University
2018-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2021-2024
Sichuan University
2013-2024
West China Second University Hospital of Sichuan University
2013-2024
Seattle Reproductive Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Stanford University
2010-2024
State Key Laboratory of Oral Diseases
2020-2022
Chengdu Women's and Children's Central Hospital
2021
Summaryγδ T cells contribute uniquely to immune competence. Nevertheless, how they function remains an enigma. It is unclear what most γδ recognize, required for them mount response, and the cell response integrated into host defense. Here, we report that a noted B antigen, algae protein phycoerythrin (PE), murine human antigen. Employing this specificity, demonstrated antigen recognition activated naive make interleukin-17 respond cytokine signals perpetuate response. High frequencies of...
Rationale: Peripheral blood monocytes are recruited into the ischemic brain and transform macrophages after stroke.Nevertheless, exact role of CCR2-dependent monocytes/ in injury stroke remains elusive.Methods: We used CCR2 knockout (KO) mice pharmacological inhibitor, propagermanium (PG), to address monocytes/macrophages acute stage neurological functional recovery middle cerebral artery (MCA) occlusion reperfusion.Results: KO resulted smaller infarct size lower mortality than wild type...
Significance The recognition of foreign peptide-MHCs by T cells is a central event in adaptive immunity that triggers antigen-specific immune responses against infections and cancer. To study cells, we devised peptide-MHC dodecamer can sensitively detect specifically stain these especially low-affinity rare ones. This technology superior to most current multimers, compatible with existing reagents, inexpensive make, easy use. It has been successfully applied studies human murine αβ γδ flow...
γδ T cells are essential for immune defense and modulating physiological processes. While they have the potential to recognize large numbers of antigens through somatic gene rearrangement, which trigger most cell response remain unidentified, role antigen recognition in function is contentious. Here, we show that some receptors (TCRs) exhibit polyspecificity, recognizing multiple ligands diverse molecular nature. These include haptens, metabolites, neurotransmitters, posttranslational...
Objectives Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disease characterised by the presence of antibodies in circulation and pathological pregnancy. However, pathogenesis OAPS remains unknown. We aimed to reveal cellular compositions molecular features decidual cells involved development using single-cell RNA sequencing (scRNA-seq). Methods performed unbiased scRNA-seq analysis on first-trimester decidua from five patients healthy controls (HCs), followed validations with...
Abstract Background Unexplained recurrent spontaneous abortion (URSA) is defined as two or more consecutive pregnancy losses, generally of unknown cause; it related to a failure fetal–maternal immunological tolerance. Regulatory T cells (Tregs) exert immunosuppressive effects, which are essential maintain tolerance and regulate immune balance. In this study, we used the specific cell-surface phenotype CD4 + CD25 high CD127 low/− Tregs investigate number suppressive function isolated from...
The ability to recognize small organic molecules and chemical modifications of host is an essential capability the adaptive immune system, which until now was thought be mediated mainly by B cell antigen receptors. Here we report that molecules, such as cyanine 3 (Cy3), a synthetic fluorescent molecule, 4-hydroxy-3-nitrophenylacetyl (NP), one most noted haptens, are γδ T antigens, recognized directly specific TCRs. Immunization with Cy3 conjugates induces rapid Cy3-specific IL-17 response....
Polycystic ovarian syndrome (PCOS) is the major cause of anovulatory infertility. Since women with PCOS are often accompanied by increased body weight and hyper response to controlled stimulation, individualized gonadotropin (Gn) dose required achieve a therapeutic effect while minimizing risk hyperstimulation simultaneously. We aimed investigate essential role in optimizing initial Gn dosage for patients during vitro fertilization (IVF). retrospectively included 409 infertile who used...
High-throughput measurement of gene-expression and immune receptor repertoires have recently become powerful tools in the study adaptive response. However, despite their now-widespread use, both tend to discard cell identity by treating populations bulk, therefore lose correlation between genetic variability at single level. In order recover this information, we developed a method simultaneously measure gene expression profiles genome mutations cells. We applied quantifying relationships...
Abstract Background Obesity may exert a negative effect on in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment. However, the of obesity endometrium remains unknown. This study was designed to assess isolated body mass index (BMI) endometrial blood supply non-polycystic ovary syndrome (PCOS) women during ICSI by power Doppler Ultrasound. Methods An observational prospective carried out. A total 206 patients without PCOS were divided into 4 groups based Chinese BMI...
Intrauterine Adhesions (IUA) is a common gynecological disease which seriously endangers the reproductive function of women without any ideal treatment. Some researchers found Menstrual Blood-derived Mesenchymal Stem Cells (MenSCs) can repair damaged endometrium, however, has not been fully clarified. This study aims to evaluate therapeutic effects MenSCs in IUA and mechanism vivo.
Acne is not only a skin condition but also cardinal component of many systemic diseases or syndromes. This study was aimed to investigate the prevalence acne in reproductive-age women Sichuan province, China, and evaluate as problem alone symptom gynecological/endocrinological disease.From October 2008 September 2009, 1043 from 19 45 years age seven communities three districts province completed standardized questionnaire physical examination. classified using Pillsbury scale, hirsutism...
We evaluated whether heat shock protein HSP70 plays a protective role in the embryos of Kunming mice subjected to chronic unpredictable mild stress. Female were stimulated for 4 weeks with nine stressors and then divided into mild, moderate severe stress groups. Superovulation was induced gonadotropin preparation (PMSG/HCG) expression 2-cell day detected by immunofluorescence (IF) real-time polymerase chain reaction (RT-PCR). In group, ovarian response oocyte development potential similar...
The influence of anti-nuclear antibody (ANA) on induced ovulation was controversial, and the effect prednisone plus hydroxychloroquine (HCQ) treatment frozen embryo transfer outcomes in-vitro fertilization (IVF) intracytoplasmic sperm injection (ICSI) for ANA-positive women unclear.Fifty one-hundred ANA-negative matched age anti-Mullerian hormone (AMH) were included from a Reproductive Medical Central University Hospital. Sixty-one oocytes pick-up (OPU) cycles in ANA+ group OPU ANA-...
Abstract Background: Polycystic ovarian syndrome (PCOS) is a heterogeneous and complex reproductive endocrinological disease that could lead to infertility. There were many attempts classify PCOS but it remains unclear whether there specific subgroup of associated with the best or worst outcomes assisted techniques (ART). Methods: Infertile patients who underwent their first cycle in vitro fertilization (IVF) West China Second University Hospital, Sichuan from January 2019 December 2021...