A5082647900- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Advanced Nanomaterials in Catalysis
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Advanced biosensing and bioanalysis techniques
- Inflammasome and immune disorders
- Neurological Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Extracellular vesicles in disease
- Aortic aneurysm repair treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vagus Nerve Stimulation Research
- Cell death mechanisms and regulation
- CAR-T cell therapy research
- Diet and metabolism studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Heme Oxygenase-1 and Carbon Monoxide
Wuhan University
2016-2025
Renmin Hospital of Wuhan University
2016-2025
Xuzhou Medical College
2025
Yangzhou University
2025
Second People’s Hospital of Huai’an
2025
Zhejiang University
2009-2024
Huzhou Central Hospital
2021-2024
Taiyuan Central Hospital
2024
Huzhou University
2022
Duke Medical Center
2022
The cerebral ischemia injury can result in neuronal death and/or functional impairment, which leads to further damage and dysfunction after recovery of blood supply. Cerebral ischemia/reperfusion (CIRI) often causes irreversible brain death, involves many complex pathological processes including oxidative stress, amino acid toxicity, the release endogenous substances, inflammation apoptosis. Oxidative stress are interactive play critical roles brain. is important process ischemic stroke for...
In order to promote preclinical and clinical applications of photoacoustic imaging, novel contrast agents are highly desired for molecular imaging diseases, especially deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles reported as an efficient agent brain tumors in living mice with enhanced permeability retention effect.
Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral ischemic stroke (IS). Ruxolitinib (Rux), selective oral JAK 1/2 inhibitor, reduces inflammatory via JAK2/STAT3 pathway. Based on its anti-inflammatory and immunosuppressive effects, we hypothesized that it may have protective effect against stroke. The aim this study was to investigate whether inhibition JAK2 has neuroprotective explore potential molecular mechanisms. Methods Rux, MCC950 or vehicle...
Ischemic stroke is a devastating disease with long-term disability. However, the pathogenesis unclear and treatments are limited. Meisoindigo, second-generation derivative of indirubin, has general water solubility well tolerated. Previous studies have shown that meisoindigo reduces inflammation by inhibiting leukocyte chemotaxis migration. In present study, we investigated hypothesis was also protective against ischemic stroke, then evaluated its underlying mechanisms. vivo, adult male...
Stroke is a primary cause of death and disability worldwide, while effective safe drugs remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle-derived multifunctional nanotherapies ischemic stroke, which are engineered from pharmacologically active oligosaccharide material (termed as TPCD) prepared by covalently conjugating radical-scavenging compound (Tempol) hydrogen-peroxide-eliminating moiety phenylboronic acid pinacol ester (PBAP) on β-cyclodextrin....
Abstract Although metallacycle‐based supramolecular photosensitizers (PSs) have attracted increasing attention in biomedicine, their clinical translation is still hindered by inherent dark toxicity. Herein, we report what to our knowledge the first example of a molecular engineering approach building blocks metallacycles for constructing series PSs ( RuA–RuD ), with aim simultaneously reducing toxicity and enhancing phototoxicity, consequently obtaining high phototoxicity indexes (PI)....
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, clinical translation of siRNA-based therapies is significantly hampered by formidable blood-brain barrier (BBB), which restricts drug penetration into central nervous system. To address this challenge, we have developed an innovative long-circulating...
Stroke causes brain injury with activation of an inflammatory response that can contribute to injury. We tested the hypothesis anti-inflammatory cytokine interleukin-4 (IL-4) reduces after stroke using IL-4 knockout (KO) adult male mice.IL-4 KO and wild-type mice were subjected transient middle cerebral artery occlusion. Outcome was assessed by triphenyltetrazolium chloride staining for infarct volume, neuroscore spontaneous activity behavioral outcome, immunostaining stereological counting...
Following transient forebrain ischemia, astrocytes play a key role in determining whether or not neurons the hippocampal CA1 sector go on to die delayed fashion. MicroRNAs (miRNAs) are novel class of RNAs that control gene expression at post‐transcriptional level and miR‐29 family is highly expressed astrocytes. In this study we assessed levels hippocampus following ischemia found after short periods reperfusion, miR‐29a significantly increased resistant dentate gyrus, but decreased...
Hypocretin/orexin (Hcrt)-producing neurons in the lateral hypothalamus project throughout brain, including to hippocampus, where Hcrt receptors are widely expressed. activate these targets orchestrate global arousal state, wake-sleep architecture, energy homeostasis, stress adaptation, and reward behaviors. Recently, has been implicated cognitive functions social interaction. In present study, we tested hypothesis that critical interaction, particularly memory, using neurobehavioral...
Despite the great potential of numerous antioxidants for pharmacotherapy diseases associated with inflammation and oxidative stress, many challenges remain their clinical translation. Herein, a superoxidase dismutase/catalase-mimetic material based on Tempol phenylboronic acid pinacol ester simultaneously conjugated β-cyclodextrin (abbreviated as TPCD), which is capable eliminating broad spectrum reactive oxygen species (ROS), reported. TPCD can be easily synthesized by sequentially...
Rationale: Peripheral blood monocytes are recruited into the ischemic brain and transform macrophages after stroke.Nevertheless, exact role of CCR2-dependent monocytes/ in injury stroke remains elusive.Methods: We used CCR2 knockout (KO) mice pharmacological inhibitor, propagermanium (PG), to address monocytes/macrophages acute stage neurological functional recovery middle cerebral artery (MCA) occlusion reperfusion.Results: KO resulted smaller infarct size lower mortality than wild type...
Pulmonary sarcomatoid carcinoma (PSC) is a rare malignancy.A total of 69 patients with PSC treated at single institution in southern China long-term follow-up were evaluated this study. We analyzed the clinical characteristics, immunohistochemical profiles, epidermal growth factor receptor mutation status, K-RAS treatments, and prognosis.PSC mainly occurred young male history smoking. Most received multimodality treatments majority had early-stage disease. The median survival time was 19.1...