A5054805221- Advanced DC-DC Converters
- Acute Ischemic Stroke Management
- Multilevel Inverters and Converters
- Advanced Battery Technologies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Silicon Carbide Semiconductor Technologies
- Intracerebral and Subarachnoid Hemorrhage Research
- Metabolomics and Mass Spectrometry Studies
- Neurological Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Tryptophan and brain disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Sensorless Control of Electric Motors
- Bipolar Disorder and Treatment
- Rocket and propulsion systems research
- Regulation of Appetite and Obesity
- Genomics and Phylogenetic Studies
- Functional Brain Connectivity Studies
- Analytical Chemistry and Chromatography
- Advanced Aircraft Design and Technologies
- Advanced MRI Techniques and Applications
- Electromagnetic Compatibility and Noise Suppression
- Physical Unclonable Functions (PUFs) and Hardware Security
- Smart Grid Security and Resilience
- S100 Proteins and Annexins
McMaster University
2022-2024
Southwest Hospital
2021-2024
Army Medical University
2021-2024
Zigong First People's Hospital
2022
Chongqing Medical University
2013
Children's Hospital of Chongqing Medical University
2013
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013
Stroke is a primary cause of death and disability worldwide, while effective safe drugs remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle-derived multifunctional nanotherapies ischemic stroke, which are engineered from pharmacologically active oligosaccharide material (termed as TPCD) prepared by covalently conjugating radical-scavenging compound (Tempol) hydrogen-peroxide-eliminating moiety phenylboronic acid pinacol ester (PBAP) on β-cyclodextrin....
Major depressive disorder (MDD) is a prevalent and debilitating mental disorder. Yet, there are no objective biomarkers available to support diagnostic laboratory testing for this disease. Here, gas chromatography-mass spectrometry was applied urine metabolic profiling of 126 MDD 134 control subjects. Orthogonal partial least-squares discriminant analysis (OPLS-DA) used identify the differential metabolites in subjects relative healthy controls. The OPLS-DA data from training samples (82...
Background The cynomolgus monkey (Macaca fascicularis) has been increasingly used in biomedical research, making knowledge of its blood-based parameters essential to support the selection healthy subjects and use preclinical research. As age sex affect these parameters, it is important establish baseline indices for on an basis determine effects indices. Methods A total 917 monkeys (374 males 543 females) were selected segregated by (five groups) sex. 30 hematological 22 biochemical...
Aviation electrification has been in the spotlight over last decade, expected to lead a more sustainable future. As power demand and voltage level of onboard electric systems dramatically increase, multilevel inverters have attracted attention aviation industry for their superior performance. This paper reviews aircraft applications. The functions different subsystems are summarized. advantages compared with two-level counterparts aircraft, terms efficiency, density, reliability, costs,...
Background Psychotherapy has demonstrated comparable efficacy to antidepressant medication in the treatment of major depressive disorder. Metabolic alterations MDD state and response have been detected by functional imaging methods, but underlying white matter microstructural changes remain unknown. The goal this study is apply diffusion tensor techniques investigate psychotherapy-specific responses matter. Methods Twenty-one forty-five outpatients diagnosed with depression underwent before...
White matter lesions are an important pathological manifestation of cerebral small vessel disease, with inflammation playing a pivotal role in their development. The adenosine A2a receptor (ADORA2A) is known to inhibit the mediated by microglia, but its effect on astrocytes unknown. Additionally, although level YKL-40 (expressed mainly astrocytes) has been shown be elevated model white induced chronic hypoperfusion, specific regulatory mechanism involved not clear. In this study, we...
As the energy crisis and environmental issues intensify, electric aircraft has become promising as a form of future transportation for its low-emission eco-friendly features. In propulsion systems, with increasing voltage power levels, multilevel inverters are considered to be superior alternatives traditional 2-level inverters. this paper, methodology is proposed compare performance different inverter topologies, i.e., 3-level active neutral point clamped (ANPC), T-type, inverter, 1MVA,...
Thermal management has always been one of the leading technical challenges in high-power power modules. Especially current trend seeking high density devices, optimized thermal design is crucial. This paper presents an optimal method for pin-fin heatsinks SiC modules, based on analytical models and Teaching Learning Based Optimization (TLBO) algorithm. First, model heatsink introduced, which combines Fourier-based conduction empirical convection model. Junction temperature <tex...
Isolated three-port dc–dc converters (TPCs) facilitate integration of three voltage sources/loads in electric vehicle applications. Three-port resonant converter (TPRC) is an attractive TPC topology as it inherits the advantages converters. Phase-shift (PS) control applied to TPRCs enables independent power flow among all ports. and duty-ratio (PSDR) introduces additional degrees freedom providing potential for improving efficiency compared PS control. This article presents a generalized...
Background Diagnosis of the cause cerebral thrombi is vital for recurrence prevention but also challenging. The presence microbiome has recently been confirmed in thrombus, suggesting a novel approach to distinguish different origins. However, little known about whether there heterogeneity microbiological colonization sources. Methods and Results Forty patients experiencing acute ischemic stroke were included clinical data collected. Metagenomic next‐generation sequencing was adopted detect...
With carbon emission becoming a global issue, electric aircraft holds great potential as the future of transportation. A multi-inverter configuration has been adopted in previous studies for propulsion systems with voltage and power levels increasing. Based on three-level active neutral-point-clamped (ANPC) topology, this paper evaluates compares performance three design cases different numbers parallel inverter cells, medium-voltage high-power systems. redundant considered, key indicators...
This article proposes a methodology of analytical modeling and optimization power modules, especially compatible with modules silver-sintered molybdenum (SSM) packaging or other insulated metal substrate types schemes. First, decoupled Fourier-based thermal model is presented, which considers the barrier effect between segments. Compared original model, it reduces average error from 93.8% to 10.9%, when estimating difference junction temperatures ( <inline-formula...
Abstract Background Malignant cerebral edema (MCE) is a common and feared complication after endovascular thrombectomy (EVT) in acute ischemic stroke (AIS). This study aimed to establish nomogram predict MCE anterior circulation large vessel occlusion (LVOS) patients receiving EVT. Methods In this retrospective cohort study, 381 with LVOS EVT were screened from 636 hospitalized two medical centers. Clinical baseline data imaging collected within 2–5 days of admission the hospital. The...