A5103091267- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Olfactory and Sensory Function Studies
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Metabolomics and Mass Spectrometry Studies
- Animal Virus Infections Studies
- Gut microbiota and health
- Cerebrovascular and Carotid Artery Diseases
- Biochemical Analysis and Sensing Techniques
- Cardiovascular and Diving-Related Complications
- Vitamin D Research Studies
- Stroke Rehabilitation and Recovery
- Virology and Viral Diseases
- Venous Thromboembolism Diagnosis and Management
- Pain Management and Treatment
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neuropharmacology Research
- Advanced NMR Techniques and Applications
- Biotin and Related Studies
Guangzhou University of Chinese Medicine
2025
Chongqing Medical University
2016-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2011-2021
Children's Hospital of Chongqing Medical University
2011-2019
First People's Hospital of Chongqing
2017
Chongqing University
2014
Major depressive disorder (MDD) is a widespread and debilitating mental disorder. However, there are no biomarkers available to aid in the diagnosis of this In study, nuclear magnetic resonance spectroscopy-based metabonomic approach was employed profile urine samples from 82 first-episode drug-naïve depressed subjects healthy controls (the training set) order identify urinary metabolite for MDD. Then, 44 unselected 52 test were used independently validate diagnostic generalizability these...
Abstract Depression is a common and heterogeneous mental disorder. Although several antidepressants are available to treat the patients with depression, factors which could affect predict treatment response remain unclear. Here, we characterize longitudinal changes of microbial composition function during escitalopram in chronic unpredictable mild stress (CUMS) mice model depression based on 16 S rRNA sequencing metabolomics. Consequently, found that (ESC) administration serves increase...
We aimed to evaluate the incidence of residual shunt after patent foramen ovale (PFO) closure and analyze anatomical features PFO determine risk factors for significant closure. Ninety-two patients who underwent at our center between September 2021 June 2022 were consecutively enrolled. Transthoracic saline contrast echocardiography was performed 6 12 months postoperatively presence a shunt. Preoperative measurements structures using transesophageal echocardiography. Binary logistic...
Bipolar disorder (BD) is a debilitating mental that cannot be diagnosed by objective laboratory-based modalities. Our previous studies have independently used nuclear magnetic resonance (NMR)-based and gas chromatography-mass spectrometry (GC-MS)-based metabonomic methods to characterize the urinary metabolic profiles of BD subjects healthy controls (HC). However, combined application NMR spectroscopy GC-MS may identify more comprehensive metabolite panel than any single platform alone....
Major depressive disorder (MDD) is a severe psychiatric disease that has critically affected life quality for millions of people. Chronic stress gradually recognized as primary pathogenesis risk factor MDD. Despite the remarkable progress in mechanism research, MDD still not well understood. Therefore, we conducted liquid chromatography-tandem mass spectrometry (LC-MS/MS) detection 25 major metabolites tryptophanic, GABAergic, and catecholaminergic pathways prefontal cortex (PFC) mice...
Bipolar disorder (BD) is a complex debilitating mental that often misdiagnosed as major depressive (MDD). Therefore, large percentage of BD subjects are incorrectly treated with antidepressants in clinical practice. To address this challenge, objective laboratory-based tests needed to discriminate from MDD patients. Here, combined gas chromatography–mass spectrometry (GC–MS)-based and nuclear magnetic resonance (NMR) spectroscopic-based metabonomic approach was performed profile urine...
Circulating vitamin D has previously been found to be lower in patients with Parkinson's disease (PD), while the effects of sunlight exposure have not yet fully investigated. Therefore, we evaluated associations between serum D, intake, exposure, and newly-diagnosed PD a Chinese population. This case-control study measured 25-hydroxyvitamin (25(OH)D) levels 201 199 controls without neurodegenerative diseases. Data on intake were obtained using self-report questionnaire. Multivariable...
Major depressive disorder is caused by gene-environment interactions and the gut microbiota plays a pivotal role in development of depression. However, underlying mechanisms remain elusive. Herein, differentially expressed hippocampal long non-coding RNAs (lncRNAs), messenger (mRNAs), microRNAs (miRNAs) between mice inoculated with from major patients or healthy controls were detected, to identify effects microbiota-dysbiosis on gene regulation patterns at transcriptome level, further...
Major depressive disorder (MDD) is a debilitating mood with various etiopathological hypotheses.
Abstract Rodent models have dominated preclinical investigations into the mechanisms of depression. However, these models-which rely on subjecting individual rodents to physical stressors - do not realistically resemble etiopathological development depression, which occurs naturally in a social context. A non-human primate model that better reflects ethological aspects depression would be more advantageous investigating pathophysiological and developing antidepressant therapeutics. Here, we...
Major depressive disorder is caused by gene-environment interactions, and the host microbiome has been recognized as an important environmental factor. However, underlying mechanisms of host-microbiota interactions that lead to depression are complex remain poorly understood.The present study aimed explore possible gut microbiota dysbiosis-induced depressive-like behaviors.We used high-performance liquid chromatography-tandem mass spectrometry analyze alterations in hippocampal lysine...
Objective The aim of this study was to compare prognostic factors and survival outcomes in patients with primary central nervous system lymphoma (PCNSL). Methods Surveillance, Epidemiology, End Results (SEER) database queried for diagnosed PCNSL between 2000 2019. Between 2019, a total 5,812 were PCNSL, whom 2,175 (37%) ≤ 60 years old 3,637 (63%) >60 old. younger had higher rate being stage I–II, receiving chemotherapy radiotherapy, similar surgery, longer time. most common...
Background Psychotherapy has demonstrated comparable efficacy to antidepressant medication in the treatment of major depressive disorder. Metabolic alterations MDD state and response have been detected by functional imaging methods, but underlying white matter microstructural changes remain unknown. The goal this study is apply diffusion tensor techniques investigate psychotherapy-specific responses matter. Methods Twenty-one forty-five outpatients diagnosed with depression underwent before...
Sex-based differences are prominent in affective disorders, but there no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used preliminarily identify sex-specific urinary metabolite diagnosing BD A male-specific biomarker panel consisting of four metabolites (α-hydroxybutyrate, choline, formate, N-methylnicotinamide) effectively discriminated between healthy controls (HC)...
The proportion of major depressive disorder (MDD) patients around the world has increased remarkably. Although many studies MDD have been conducted based on classic hypotheses, like alteration hypothalamic-pituitary-adrenal axis or monoamine neurotransmitters, mechanisms underlying remain unclear. Aiming to further investigate MDD, liquid chromatography-tandem mass spectrometry was employed measure target metabolites in hippocampus (HIPPO) chronic social defeat stress model mice. Compared...