A5100338175- Ginseng Biological Effects and Applications
- Tryptophan and brain disorders
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Genomic variations and chromosomal abnormalities
- Metabolism and Genetic Disorders
- Cancer, Lipids, and Metabolism
- Polyoxometalates: Synthesis and Applications
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Neuroscience and Neuropharmacology Research
- Metal-Organic Frameworks: Synthesis and Applications
- Nuts composition and effects
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Prenatal Screening and Diagnostics
- Fermentation and Sensory Analysis
- Ginger and Zingiberaceae research
- Microbial Metabolism and Applications
- Genomics and Rare Diseases
- RNA modifications and cancer
- Agriculture, Soil, Plant Science
Qingdao Agricultural University
2025
Kunming University of Science and Technology
2025
Shandong University of Traditional Chinese Medicine
2025
Fifth Affiliated Hospital of Sun Yat-sen University
2025
Chongqing Medical University
2014-2024
Huzhou Women and Children's Hospital
2024
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
Weatherford College
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
To identify bioactive equivalent combinatorial components (BECCs) in herbal medicines. The exact composition of effective medicines is often elusive due to the lack adequate screening methodology. Herein, we propose a hypothesis that BECCs accounting for whole efficacy original could be discovered from complex mixture constituents.We developed equivalence oriented feedback method and applied it discover an preparation Cardiotonic Pill (CP). operations include chemical profiling CP, followed...
PAX6 is a master regulatory gene involved in neuronal cell fate specification. It also plays critical role early eye field and subsequent limbal stem (LSC) determination during development. Defects Pax6 cause aniridia LSC deficiency humans the Sey (Small eye) phenotype mice (Massé, K., Bhamra, S., Eason, R., Dale, N., Jones, E. A. (2007) Nature 449, 1058-1062). However, how specifies corneal fates development not well understood. Here, we show that expressed primitive cup later tissue...
Diabetic nephropathy (DN) is one of the serious microvascular complications diabetes mellitus (DM). A growing body research has demonstrated that inflammatory state plays a critical role in incidence and development DN. Pyroptosis new way programmed cell death, which particularity natural immune inflammation. The inhibition cytokine expression regulation pathways related to pyroptosis may be novel strategy for DN treatment. aim this study identify pyroptosis-related genes potential drugs...
Various diseases have seriously threatened the health of Chinese residents. Sensitive and accurate analysis disease markers is very important for early diagnosis, treatment, prognosis evaluation diseases. Therefore, it great clinical significance to explore a sensitive, accurate, rapid, noninvasive detection technology. Surface-enhanced Raman spectroscopy (SERS) uses light interact with gold, silver, other nanostructured materials generate strong surface plasmon resonance effect, which can...
In humans and other mammals, the process of oogenesis initiates asynchronously in specific ovarian regions, leading to localization dormant growing follicles cortex medulla, respectively; however, current understanding this remains insufficient. Here, we integrate single-cell RNA sequencing (scRNA-seq) spatial transcriptomics (ST) comprehend spatial–temporal gene expression profiles explore organization microenvironments during early pigs. Projection germ cell clusters at different stages...
To address the problem of complex field conditions and high similarity between corn seedlings weeds, this study proposes an improved DETR (Detection Transformer) model for weed detection in fields, which uses CBAM convolutional attention mechanism model, a focal loss function instead traditional cross-entropy to balance number positive negative class samples data. Compared with original mAP (Mean Average precision) was increased by 1.12% 91.56%.
Burn wound management is challenging, and while mesenchymal stem cell-derived exosomes show therapeutic potential, optimal delivery methods are unclear. To study chitosan (CS)-αβ-glycerophosphate (CS-αβ-GP) hydrogel crosslinked with adipose-derived cell (ASC-Exos) for healing deep burn injuries. Rats injuries were divided into the CS + ASCs-Exos group, control group. The rates on days 4, 7, 14 after treatment analyzed using ImageJ software. On day 14, tissues stained hematoxylin eosin...
Bcl-2 associated athanogene-5 (BAG5) represents a unique BAG cochaperone family member, regulating chaperone activity. We first demonstrated significant differences in Bag5 expression by RNA seq analysis of teratozoospermia and healthy male sperm samples, but the genetic molecular mechanisms governing this process remain elusive. further found that BAG5 has highest human mouse testes. is elevated late stage pachytene spermatocytes spermatids. Targeted inactivation mice induces massive...
Objective: To study the changes and clinical effects of elderly patients with coronary heart disease chronic failure after applying individualized cardiac rehabilitation. Methods: 85 cases admitted from June 2023 to May 2024 were divided into control group (42 cases) experimental (43 cases), given conventional rehabilitation guidance training programme respectively, comparing indexes exercise endurance, level function, quality life, incidence adverse cardiovascular events in two groups....
Climate change has direct impacts on wildlife and future biodiversity protection efforts. Vulnerability assessment habitat connectivity analyses are necessary for drafting effective conservation strategies threatened species such as the Tibetan brown bear (Ursus arctos pruinosus). We used maximum entropy (MaxEnt) model to assess current (1950-2000) (2041-2060) suitability by combining bioclimatic environmental variables, identified potential climate refugia bears in Sanjiangyuan National...
Major depressive disorder (MDD) patients in different age ranges might have urinary metabolic phenotypes, because could significantly affect the physiological and psychological status of person.Therefore, it was very important to take into consideration when studying MDD.Here, a dual platform metabolomic approach performed profile urine samples from young middle-aged MDD patients.In total, 18 15 differential metabolites that separately discriminated patients, respectively, their respective...
Chronic obstructive pulmonary disease (COPD) is an important risk factor for developing lung cancer. Aged citrus peel (chenpi) has been used as a dietary supplement respiratory diseases in China.To explore the mechanism and candidate compounds of chenpi preventing COPD its progression to cancer.The active components potential targets were retrieved from Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Disease-associated cancer collected Gene Cards TTD The component-target...
Abstract Background Newborn screening (NBS), such as tandem mass spectrometry (MS/MS), may yield false positive/negative results. Next-generation sequencing (NGS) has the potential to provide increased data output, efficiencies, and applications. This study aimed analyze types distribution of pathogenic gene mutations in newborns Huzhou, Zhejiang province, China explore applicability NGS MS/MS NBS. Methods Blood spot samples from 1263 were collected. was employed screen for variants 542...
Abstract Catalytic asymmetric cascade reactions in which the substrates are transferred through well‐choreographed consecutive independent steps by a single catalyst have received increasing interest. By incorporating chiral organocatalyst pyrrolidine, an oxidation polyoxometalate and Lewis acid copper(II) into porous coordination network (PCN), two enantiomorph CuW‐PYIs (PYI=pyrrolidine‐2‐yl‐imidazole) with novel Kagomé lattice were achieved applied conversion of aldehyde ketone value‐added...
Tetracycline is one of the most commonly used antibiotics in world.