A5075566791- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Gut microbiota and health
- Diet and metabolism studies
- Photoacoustic and Ultrasonic Imaging
- Alzheimer's disease research and treatments
- Ultrasound and Hyperthermia Applications
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Cardiac Ischemia and Reperfusion
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Gastrointestinal motility and disorders
- Neuroscience and Neuropharmacology Research
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Vagus Nerve Stimulation Research
- Saffron Plant Research Studies
- Hydraulic Fracturing and Reservoir Analysis
- Medicinal Plants and Bioactive Compounds
- Antifungal resistance and susceptibility
- Circular RNAs in diseases
- Drilling and Well Engineering
Xiamen University
2025
Fujian Medical University
2025
Fujian University of Traditional Chinese Medicine
2025
Second Hospital of Hebei Medical University
2011-2024
Hebei Medical University
2008-2024
Ningxia Medical University
2024
Huazhong Agricultural University
2024
Yangtze University
2012-2023
Nanjing Agricultural University
2021-2022
Wenzhou Medical University
2019-2022
Abstract Background Modification of the gut microbiota has been reported to reduce incidence type 1 diabetes mellitus (T1D). We hypothesized that shifts might also have an effect on cognitive functions in T1D. Herein we used a non-absorbable antibiotic vancomycin modify streptozotocin (STZ)-induced T1D mice and studied impact microbial changes performances its potential gut-brain neural mechanism. Results found exposure disrupted microbiome, altered host metabolic phenotypes, facilitated...
To identify bioactive equivalent combinatorial components (BECCs) in herbal medicines. The exact composition of effective medicines is often elusive due to the lack adequate screening methodology. Herein, we propose a hypothesis that BECCs accounting for whole efficacy original could be discovered from complex mixture constituents.We developed equivalence oriented feedback method and applied it discover an preparation Cardiotonic Pill (CP). operations include chemical profiling CP, followed...
This study was designed to investigate the knowledge and opinions of hospital pharmacists about spontaneous reporting adverse drug reactions (ADRs) in Inner Mongolia, a northern region China.A face-to-face questionnaire survey conducted five tertiary general hospitals Mongolia between July December 2007. The structured consisted questions demographic details pharmacists, their pharmacovigilance on pharmacists' involvement ADR reporting.Of 288 visited, 246 responded giving total response rate...
Background/Aims: Exosomes are extracellular vesicles that involved in several biological processes. The roles of proteins from human umbilical cord blood exosomes the pathogenesis preeclampsia remains poorly understood. Methods: In this study, we used high-resolution LC-MS/MS technologies to construct a comparative proteomic profiling between normal and preeclamptic pregnancies. Results: A total 221 were detected exosomes, with 14 upregulated 15 downregulated definitively identified control...
Background: The placenta acts not only as a conduit of nutrient and waste exchange between mother developing fetus but also functions regulator the intrauterine environment. Pre-eclampsia (PE) gestational diabetes mellitus (GDM) are leading causes complications during pregnancy. Pathophysiologies show that they associated with one another. Epigenetics provides link environmental factors have previously been linked to poor pregnancy outcomes fetal programming. Methods Results: present study...
Cortical neuron-released exosomes have been demonstrated to block inflammasome activation in the central nervous system. This study aimed investigate whether cortical exosomal microRNA-181c-3p (miR-181c-3p) affected ischemic brain injury (IBI).An IBI rat model was established by middle cerebral artery occlusion (MCAO). Astrocytes collected from rats were exposed derived neurons effect of on chemokine (C-X-C motif) ligand 1 (CXCL1) expression and inflammatory response. Then, ectopic induced...
Obesity is becoming a major public health problem due to excess dietary fat intake. Dendrobium officinale (D. officinale) medicine food homology plant and exerts multiple health-promoting effects. However, its antiobesity effects the potential mechanisms remain unclear.High-fat diet (HFD)-fed mice are administered D. fiber (DODF) daily by gavage for 11 weeks. The results show that treatment with DODF alleviates obesity, liver steatosis, inflammation, oxidant stress in HFD-induced obese mice....
Low-intensity transcranial ultrasound stimulation (TUS) has been effective in modulating several neurological and psychiatric disorders. However, how TUS modulates neuronal firing activity synaptic plasticity remains unclear. Thus, we behaviorally tested the whisker-dependent novel object discrimination ability mice after examined cortical awake by two-photon fluorescence imaging. The current study presented following results: (1) could significantly improve new of mice, suggesting that...
Transcranial ultrasound stimulation (TUS) is a noninvasive brain neuromodulation technique. The application of TUS for Alzheimer's disease (AD) therapy has not been widely studied. In this study, long-term course (28 days) was used to stimulate the hippocampus APP/PS1 mice. We examined modulatory effect on behavior and neural oscillation in AD found that can (1) improve learning memory abilities mice; (2) reduce phase-amplitude coupling delta-epsilon, delta-gamma theta-gamma frequency bands...
Although astragaloside IV, a saponin isolated from <i>Astragalus membranaceus</i>, has been shown to protect the myocardium against ischemia/reperfusion injury, its effect on status of sarcoplasmic reticulum (SR) Ca<sup>2+</sup> transport in injured remains largely unknown. In this study, we investigated whether cultured cardiomyocytes subjected hypoxia and reoxygenation (H/R) administration IV during H/R attenuates myocardial cell injury prevents changes handling...