A5100369921- Body Composition Measurement Techniques
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Function and Risk Factors
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Cardiac Imaging and Diagnostics
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Traumatic Brain Injury and Neurovascular Disturbances
- Fibroblast Growth Factor Research
- Neurological Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Neurological disorders and treatments
- Thermoregulation and physiological responses
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Traditional Chinese Medicine Analysis
Renmin Hospital of Wuhan University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Wuhan University
2024-2025
West China Hospital of Sichuan University
2010-2025
Nanjing Medical University
2022-2025
Hunan Normal University
2025
Hunan Provincial People's Hospital
2025
Peking University
2023-2025
Peking University Third Hospital
2023-2025
Wenzhou Medical University
2009-2024
In recent years, some studies have indicated that a novel marker described as the stress hyperglycemia ratio (SHR) can reflect true acute hyperglycemic status and is associated with short-term poor prognosis in patients myocardial infarction. current study we evaluated association of SHR adverse cardiovascular events among coronary syndrome (ACS).We consecutively enrolled 5,562 ACS who underwent drug-eluting stent (DES) implantation. All subjects were divided into five groups according to...
Abstract Background Modification of the gut microbiota has been reported to reduce incidence type 1 diabetes mellitus (T1D). We hypothesized that shifts might also have an effect on cognitive functions in T1D. Herein we used a non-absorbable antibiotic vancomycin modify streptozotocin (STZ)-induced T1D mice and studied impact microbial changes performances its potential gut-brain neural mechanism. Results found exposure disrupted microbiome, altered host metabolic phenotypes, facilitated...
Three structural elements for protein assembly are proposed, which guide superfast amyloid-like globular aggregation towards macroscopic nanofilms and microparticles.
Abstract Background Non-diabetic coronary artery disease (CAD) patients are thought to encounter metabolic dysfunction and while these changes may be imperceptible the patient they probably influence outcomes. At present, there is no system support sensing subtle changes, nor an established model for prognoses. The Atherogenic Index of Plasma (AIP) index has already proven useful atherosclerosis although further research needed, especially those without hyperglycemia. Methods This a...
The emergence of lipid droplets (LDs) has been recognized as cellular markers ocular surface hyperosmosis, which is a fundamental mechanism driving dry eye disease (DED), while their dynamics during DED progression and therapy remains unlocked. For this purpose, an LD-specific fluorescent probe P1 presented in work that exhibits highly selective sensitive emission enhancement response to decreased ambient polarity (Δf) from 0.209 0.021. hydrophobic nature enables specific staining LDs,...
Cell fate decision involves rewiring of the genome, but remains poorly understood at chromatin level. Here, we report that remodeling complex NuRD participates in closing open early phase somatic reprogramming. Sall4, Jdp2, Glis1 and Esrrb can reprogram MEFs to iPSCs efficiently, only Sall4 is indispensable capable recruiting endogenous components NuRD. Yet knocking down reduces reprogramming modestly, contrast disrupting known Sall4-NuRD interaction by mutating or deleting interacting motif...
The gut microbiota has the capability to regulate homeostasis of host metabolism. Since antibiotic exposure can adversely affect microbiome, we hypothesized that effects on and metabolism are sex dependent. In this study, examined treatments, including vancomycin (Vanc) ciprofloxacin-metronidazole (CiMe), microbiome metabolome in colonic contents tissues both male female mice. We found relative abundances structural composition Firmicutes were significantly reduced mice after Vanc CiMe...
The deregulation of S100A2 has been implicated in the pathogenesis several types cancers. However, molecular mechanisms underlying protumorigenic capacities have not fully elucidated. Here, we demonstrated roles glycolysis reprogramming and proliferation colorectal cancer (CRC) cells. results indicated that overexpression raises glucose metabolism proliferation. Mechanistically, activated PI3K/AKT signaling pathway, upregulated GLUT1 expression, induced glycolytic reprogramming, consequently...
Type 1 diabetes (T1D) causes cognitive decline and has been associated with brain metabolic disorders, but its potential molecular mechanisms remain unclear. The purpose of this study was to explore the underlying T1D-induced impairment using metabolomics lipidomics. We developed an optimized integration approach lipidomics for tissue based on UPLC-Q-TOF-MS analyzed a comprehensive characterization metabolite lipid profiles in hippocampus frontal cortex T1D male mice (T1DCD) age-matched...
Obesity is becoming a major public health problem due to excess dietary fat intake. Dendrobium officinale (D. officinale) medicine food homology plant and exerts multiple health-promoting effects. However, its antiobesity effects the potential mechanisms remain unclear.High-fat diet (HFD)-fed mice are administered D. fiber (DODF) daily by gavage for 11 weeks. The results show that treatment with DODF alleviates obesity, liver steatosis, inflammation, oxidant stress in HFD-induced obese mice....
Diabetes mellitus causes brain structure changes and cognitive decline, it has been estimated that diabetes doubles the risk for dementia. Until now, pathogenic mechanism of diabetes-associated decline (DACD) remained unclear. Using metabolomics, we show lactate levels increased over time in hippocampus rats with streptozotocin-induced diabetes, as compared age-matched control rats. Additionally, mRNA levels, protein enzymatic activity dehydrogenase-A (LDH-A) were significantly up-regulated,...
Microglial polarization and the subsequent neuroinflammatory response were identified as key contributors to progress of Parkinson's disease (PD). Researchers have shown that fibroblast growth factor 21 (FGF21) plays multiple biological functions, including anti-inflammation neuroprotection. However, knowledge FGF21 on microglial in PD vivo is far from completion. In this study, both vitro models used investigate whether enhances brain function by modulating PD. The protective effects...
✓ An analysis of Motor Index score, pinprick sensory joint position sense somatosensory evoked potential (SSEP) grade in the ulnar (SSEP u ) and posterior tibial t regions, overall SSEP (mean u+t was conducted 36 patients with cervical spinal cord injuries to determine relationship these scores, both individually combination, functional outcome (as determined using Barthel Index) at 6 months after injury. The clinical electrophysiological data were obtained on same day within 2 weeks...
Abstract A major hallmark of mutant superoxide dismutase (SOD1)‐linked familial amyotrophic lateral sclerosis is SOD1‐immunopositive inclusions found within motor neurons. The mechanism by which SOD1 becomes aggregated, however, remains unclear. In this study, we aimed to investigate the role nitrosative stress and S‐nitrosylation protein disulfide isomerase (PDI) in formation aggregates. Our data show that with disease progression inducible nitric oxide synthase (iNOS) was up‐regulated,...
Colorectal cancer (CRC) is the third leading causes of mortality, and early-stage detection could significantly enhance survival rates. Cancer influences important metabolic pathways changes in metabolite levels had been used many studies as potential biomarkers. This study aimed at screening biomarkers with CRC diagnosis potentials. The direct infusion mass spectrometry (MS) metabolomic analysis based on dried blood spot was to distinguish from polyp. target metabolites were composed 23...