A5077247479- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Voice and Speech Disorders
- Artificial Intelligence in Healthcare and Education
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Brain Tumor Detection and Classification
- Acupuncture Treatment Research Studies
- Winter Sports Injuries and Performance
- Medical Imaging and Analysis
- Hearing, Cochlea, Tinnitus, Genetics
- Non-Invasive Vital Sign Monitoring
- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Nuclear Receptors and Signaling
- AI in cancer detection
Huashan Hospital
2016-2025
Fudan University
2016-2025
Army Medical University
2019-2022
Daping Hospital
2019-2022
Human post mortem studies have described the topographical patterns of tau pathology in progressive supranuclear palsy (PSP). Recent advances PET tracers are expected to herald next era PSP investigation for early detection living brains. This study aimed investigate whether 18F-Florzolotau imaging may capture distribution and regional vulnerability PSP, devise a novel image-based staging system.The cohort consisted 148 consecutive patients with who had undergone imaging. The rating scale...
The underlying mechanism of brain glucose hypometabolism, an invariant neurodegenerative feature that tightly correlates with cognitive impairment and disease progression Alzheimer's (AD), remains elusive.Positron emission tomography 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) was used to evaluate metabolism, presented as the rate standardized uptake value ratio (FDG SUVR) in patients AD or control subjects mice without thiamine deficiency induced by a thiamine-deprived diet. Brain amyloid-β...
ABSTRACT Background Recent development in tau‐sensitive tracers has sparkled significant interest tracking tauopathies using positron emission tomography (PET) biomarkers. However, the ability of 18 F‐florzolotau PET imaging to topographically characterize tau pathology corticobasal syndrome (CBS) remains unclear. Further, question as whether disease‐level differences exist with other neurodegenerative is still unanswered. Objective To analyze topographical patterns living brains patients...
ABSTRACT Background Progressive supranuclear palsy (PSP) is a primary tauopathy characterized by dopaminergic impairment and abnormal glucose metabolism. The glymphatic system can promote the elimination of tau protein. association between function pathological hallmark in neuroimaging remains unknown. Methods Diffusion tensor imaging (DTI) positron emission tomography (PET) scanning with 18 F‐Florzolotau, F‐FPCIT, F‐FDG were performed PSP patients. DTI analysis along perivascular space...
The recently proposed body-first and brain-first subtypes are classified based on the initial localization of α-synuclein inclusions. This study investigated plasma biomarkers cerebral glucose metabolism characteristics in putative PD subjects. patients without possible RBD (PDpRBD–) (n = 58) with symptoms discovered before motor (PDpRBD+) 43) were recruited. Single-molecule array (SimoA) was used for measuring biomarkers, including glial fibrillary acidic protein (GFAP), neurofilament light...
Objective: To study the changes and clinical effects of elderly patients with coronary heart disease chronic failure after applying individualized cardiac rehabilitation. Methods: 85 cases admitted from June 2023 to May 2024 were divided into control group (42 cases) experimental (43 cases), given conventional rehabilitation guidance training programme respectively, comparing indexes exercise endurance, level function, quality life, incidence adverse cardiovascular events in two groups....
ABSTRACT Background Anecdotal evidence suggests that patients diagnosed with the parkinsonian subtype of multiple system atrophy (MSA‐P) may show uptake second‐generation tau positron emission tomography (PET) tracer 18 F‐Florzolotau (previously known as F‐APN‐1607) in putamen. Objectives This study systematically investigated localization and magnitude a relatively large cohort MSA‐P. Methods PET imaging was performed 31 MSA‐P, 24 Parkinson's disease (PD), 20 age‐matched healthy controls....
18F-FDG positron emission tomography (PET) is a reliable technique to quantify regional neural glucose metabolism even with major depressive disorder (MDD) heterogeneous features. Previous study proposed that in the resting-state (RS), pairs of brain regions whose metabolic rates were significantly correlated functionally associated. This synchronicity indicates neuronal and functional interaction high energy efficient regions. In this study, multimode method was used identify RS-FC patterns...
Abstract Purpose Dopamine transporter imaging is routinely used in Parkinson’s disease (PD) and atypical parkinsonian syndromes (APS) diagnosis. While [ 11 C]CFT PET prevalent Asia with a large APS database, Europe relies on 123 I]FP-CIT SPECT limited data. Our aim was to develop deep learning-based method convert images images, facilitating multicenter studies overcoming data scarcity promote Artificial Intelligence (AI) advancements. Methods A CycleGAN trained ( n = 602, 72%PD) 1152,...
Both glucose metabolism and resting-state fMRI (RS-fMRI) signal reflect hemodynamic features. The objective of this study was to investigate their relationship in the healthy elderly participants (n = 18). For RS-fMRI signal, regional homogeneity (ReHo), amplitude low frequency fluctuations (ALFF), fractional ALFF (fALFF), degree centrality (DC) maps were generated multiple bands. Glucose uptake acquired with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Linear correlation...
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Abstract Background Tau pathology is observed during autopsy in many patients with Parkinson's disease dementia (PDD). Positron emission tomography (PET) imaging using the tracer 18 F‐florzolotau has potential to capture tau accumulation living brain. Objective The aim was describe results of PET/CT (computed tomography) PDD. Methods Ten PDD, 9 normal cognition (PD‐NC), and age‐matched healthy controls (HCs) were enrolled. Clinical assessments performed. Results F‐Florzolotau uptake...
Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI) are closely associated with Tau proteins accumulation. In this study, we aimed to implement radiomics analysis discover high-order features from pathological biomarker improve the classification accuracy based on PET images. Two cross-racial independent cohorts ADNI database (121 AD patients, 197 MCI patients 211 normal control (NC) subjects) Huashan hospital (44 33 36 NC were enrolled. The of imaging related brain regions computed...
Abstract Tinnitus is associated with neural hyperactivity in the central nervous system (CNS). Salicylate a well-known ototoxic drug, and we induced tinnitus rats using model of long-term salicylate administration. The gap pre-pulse inhibition acoustic startle test was used to infer perception, only chronic salicylate-treatment (14 days) group showed evidence experiencing tinnitus. After small animal positron emission tomography scans were performed, found that metabolic activity inferior...
Purpose: Constraint-induced movement therapy (CIMT) can improve motor functions in stroke patients and ischemic rats. This study examined the effect of CIMT rats using positron emission tomography (PET).Methods: We used middle cerebral artery occlusion (MCAO) procedure to induce ischemia Male were divided into a negative control group (Normal, n = 4), sham-operated (Sham, 6), an (Control, 6) CIMT-treated (CIMT, 6). started at postoperative day 8 (d8) lasted for 2 weeks. utilized...
Abstract Background Dementia with Lewy bodies (DLB) commonly exhibits a complex neuropathology, sharing characteristics Alzheimer's disease (AD), including tau aggregates. However, studies using the 18 F‐AV‐1451 tracer have shown inconsistent findings regarding both extent and topographical distribution of pathology in DLB. Objectives Our aim was to elucidate patterns deposition DLB investigate vivo pathological distinction between AD virtue F‐Florzolotau positron emission tomography (PET)...
A majority of blast-induced mild traumatic brain injury (mTBI) patients experience persistent neurological dysfunction with no findings on conventional structural MR imaging. It is urgent to develop advanced imaging modalities detect and understand the pathophysiology mTBI. Fluorine-18 fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) could neuronal function activity injured brain, while spectroscopy provides complementary information assesses metabolic irregularities following...
Reduced dopamine transporter (DAT) binding in the striatum has been reported patients with progressive supranuclear palsy (PSP). However, relationship between striatal dopaminergic lesions and disease severity of PSP remains to be explored.To investigate contributions PSP.One hundred clinically diagnosed were consecutively enrolled this study. The was systemically assessed using rating scale (PSPrs), 11C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane positron emission tomography (11C-CFT PET)...
18F-Florzolotau is a novel second-generation tau radiotracer that shows higher binding affinity and selectivity no off-target binding. The proportion loss of functional connectivity strength (PLFCS) new indicator for representing brain (FC) alteration. This study aims to estimate the relationship between regional accumulation FC abnormality in Alzheimer's disease (AD) mild cognitive impairment (MCI) patients based on Florzolotau PET fMRI.22 NC (normal control), 31 MCI 42 AD who have already...
Insufficient cerebral perfusion is suggested to play a role in the development of Alzheimer disease (AD). However, there lack direct evidence indicating whether hypoperfusion causes or aggravates AD pathology. We investigated effect chronic on AD-related pathology humans.We enrolled group cognitively normal patients (median age: 64 years) with unilateral hypoperfusion. Regions interest most pronounced changes were chosen hypoperfused region and then mirrored contralateral hemisphere create...