A5024396573- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Nerve injury and regeneration
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- S100 Proteins and Annexins
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Genetic Associations and Epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Peroxisome Proliferator-Activated Receptors
- Bone and Joint Diseases
- International Business and FDI
- Neurological Disorders and Treatments
- Prion Diseases and Protein Misfolding
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Drug Transport and Resistance Mechanisms
- Atrial Fibrillation Management and Outcomes
- 14-3-3 protein interactions
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 Clinical Research Studies
Army Medical University
2015-2025
Daping Hospital
2015-2025
Hainan Medical University
2021-2025
Hainan General Hospital
2022
Shanghai University of Finance and Economics
2011-2022
Chengdu University
2020
Sichuan Agricultural University
2020
Creative Commons
2017
National Natural Science Foundation of China
2017
Zoological Institute
2016
Previous studies suggest that gut microbiota is associated with neuropsychiatric disorders, such as Parkinson's disease, amyotrophic lateral sclerosis, and depression. However, whether the composition diversity of altered in patients Alzheimer's disease (AD) remains large ly unknown. In present study, we collected fecal samples from 43 AD age- gender-matched cognitively normal controls. 16S ribosomal RNA sequencing technique was used to analyze feces. The different between two groups....
Background and purpose Previous studies suggested that the overall burden of prior infections contributes to cardiovascular diseases stroke. In present study, association between infectious ( IB ) Alzheimer's disease AD was examined. Methods Antibody titers common pathogens including cytomegalovirus CMV ), herpes simplex virus type 1 HSV ‐1), B orrelia burgdorferi , C hlamydophila pneumoniae H elicobacter pylori were measured by enzyme‐linked immunosorbent assay in 128 patients 135 healthy...
Significance Alzheimer’s disease (AD) is a devastating that results in the progressive cognitive deficits of elderly and has become one major social economic burdens worldwide. There no effective drug or therapy to prevent halt dysfunctions due complex mechanisms such as accumulation amyloid-β (Aβ), increase oxidative stress, formation neurofibrillary tangle drive development disease. We found here Edaravone, been used for ischemic stroke, able treat AD by targeting multiple pathways...
In Alzheimer's disease (AD), neurodegenerative signals such as amyloid-beta (Aβ) and the precursors of neurotrophins, outbalance neurotrophic signals, causing synaptic dysfunction neurodegeneration. The neurotrophin receptor p75 (p75NTR) is a Aβ mediates Aβ-induced signals. shedding its ectodomain from cell surface physiologically regulated; however, function diffusible p75NTR (p75ECD) after remains largely not known. Here, we show that p75ECD levels in cerebrospinal fluid brains patients...
Abstract A critical link between amyloid-beta (Aβ) and hypoxia has been demonstrated in vitro animal studies but not yet proven humans. Obstructive sleep apnea syndrome (OSAS) is a common disorder that characterized by nocturnal intermittent hypoxaemia. This study sought to examine the association chronic Aβ OSAS patients. Forty-five cognitively normal patients forty-nine age- gender-matched subjects diagnosed with simple snoring were included present study. Serum Aβ40, Aβ42, total tau...
Abstract Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role pathogenesis sporadic Alzheimer’s disease (AD). The roles blood monocytes development AD remain unclear. In this study, we sought to investigate alterations Aβ phagocytosis function peripheral during ageing and patients. A total 104 cognitively normal participants aged 22–89 years, 24 patients, 25 age- sex-matched (CN) subjects, 15 Parkinson’s patients (PD), CN subjects were recruited. uptake by was measured its...
Alzheimer disease (AD) has been made a global priority for its multifactorial pathogenesis and lack of disease-modifying therapies. We sought to investigate the changes profile blood routine in AD correlation with severity.In all, 92 patients 84 age sex-matched normal controls were enrolled their profiles evaluated.Alzheimer had increased levels mean corpuscular hemoglobin, volume, red cell distribution width-standard deviation, platelet volume,and decreased width, cell, hematocrit,...
The underlying mechanism of brain glucose hypometabolism, an invariant neurodegenerative feature that tightly correlates with cognitive impairment and disease progression Alzheimer's (AD), remains elusive.Positron emission tomography 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) was used to evaluate metabolism, presented as the rate standardized uptake value ratio (FDG SUVR) in patients AD or control subjects mice without thiamine deficiency induced by a thiamine-deprived diet. Brain amyloid-β...
Alzheimer's disease (AD) is the most common type of dementia affecting aged population worldwide, yet its social perceptions have been less studied. To investigate and attitudes toward AD in Chinese population, a cross-sectional face-to-face survey 2,000 randomly selected adults was conducted five representative cities China. This focused on fear AD, relationship between this variable each studied factor analyzed using univariate analysis multivariate regression analysis. In general, 76.6%...
Neurofibrillary tangles of hyperphosphorylated tau protein (p-tau) are a key pathological feature Alzheimer's disease (AD). Tau phosphorylation is suggested to be secondary amyloid-beta (Aβ) accumulation. However, the mechanism by which Aβ induces in neurons remains unclear. Neurotrophin receptor p75 (p75NTR) for and mediates neurotoxicity, implying that p75NTR may mediate Aβ-induced AD. Here, we showed hyperphosphorylation neurodegeneration, including phosphorylation, synaptic disorder...
Coronavirus disease 2019 (COVID-19) can lead to persistent symptoms, sequelae, and other medical complications that may last for weeks or months after recovery. The aim of the study is assess prevalence risk factors long COVID-19 persisting 2 years in Hainan Province, China, aid its recognition, prevention, treatment. Between July August 2022, 960 individuals with confirmed SARS-CoV-2 infection Hainan, were recruited. An epidemiological questionnaire was conducted via phone interviews...
Platelet factor 4 (PF4), a chemotactic secreted from the α-granules of platelets, has recently been proved to mitigate neuroinflammation and improve aging-related cognition decline, which may be involved in Alzheimer's disease (AD). This study aims investigate alterations serum PF4 levels AD, correlation between β-amyloid (Aβ) tau cerebrospinal fluid (CSF), potential diagnostic utility AD. A cross-sectional was conducted involving 38 amyloid-positive AD patients 50 cognitively normal...
ABSTRACT Revealing the temporal evolution of cerebrospinal fluid (CSF) biomarkers during aging is critical to understanding disease pathogenesis and developing early diagnoses interventions for Alzheimer's (AD). CSF was obtained from 549 cognitively normal subjects between 18 93 years age. 12 AD‐related were evaluated, including amyloid β (Aβ42, Aβ40, Aβ42/Aβ40 ratio), hyperphosphorylated tau (P‐tau), neuronal injury/degeneration (T‐tau, NFL, NSE, H‐FABP, VILIP‐1), neuroinflammation (YKL‐40,...
Background: Systemic factors confound blood tests for the diagnosis of Alzheimer disease (AD). The Delta study explored whether biomarkers from vein proximal to brain perform better in detecting cerebral AD pathologies. Methods: Blood was collected internal jugular (IJV) and median cubital (MCV) discovery (n=371) validation (n=92) cohorts. were measured with Lumipulse G Simoa methods. Aβ tau PET imaging cerebrospinal fluid (CSF) used evaluate Results: levels Aβ42, Aβ40, p-tau217, p-tau181,...
Abstract INTRODUCTION This study was undertaken to evaluate the diagnostic performance of a novel plasma phosphorylated tau (p‐tau) 217/amyloid beta (Aβ) 42 ratio test for Alzheimer's disease (AD). METHODS The Lumipulse G p‐tau217/Aβ42 evaluated using Aβ and positron emission tomography (PET) as reference standards in clinic cohort ( n = 391) community 121). RESULTS Plasma exhibited high abnormal statuses PET (area under curve [AUC]: 0.963 0.966) (AUC: 0.947 0.974), which were clinically...
Parkinson's disease (PD) and Parkinsonism are common neurodegenerative disorders with continuously increasing prevalence, causing high global burdens. However, data concerning the comorbidity burden of patients PD or in China lacking. To investigate health condition burden, a total 3367 823 were included from seven tertiary hospitals cities across 2003 to 2012. Their was collected quantified by Elixhauser Comorbidity Index (ECI) Charlson (CCI). The spectra differed between patients. Compared...
NAbs to different epitopes of Aβ are differentially associated with the severity and progression Alzheimer’s disease.
Blood transcriptome has emerged as a potential resource for the discovery of biomarkers Alzheimer's disease (AD). However, validity blood in early diagnosis AD yet to be extensively tested. In this work, we analyzed published data on and revealed characteristic perturbation cellular functional units, including upregulation environmental responses (immune response, survival/death signaling, recycling) down-regulation core metabolism (energy translation/splicing). This was unique based...