A5049495987- Advanced Drug Delivery Systems
- Curcumin's Biomedical Applications
- Polymer composites and self-healing
- Additive Manufacturing and 3D Printing Technologies
- Drug Solubulity and Delivery Systems
- Pharmacological Effects of Natural Compounds
- Alzheimer's disease research and treatments
- Advancements in Transdermal Drug Delivery
- Microbial Metabolites in Food Biotechnology
- Cholinesterase and Neurodegenerative Diseases
- Analytical Methods in Pharmaceuticals
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Antimicrobial agents and applications
- Colorectal Cancer Surgical Treatments
- Hydrogels: synthesis, properties, applications
- Lignin and Wood Chemistry
- Wound Healing and Treatments
- Polysaccharides and Plant Cell Walls
- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Inhalation and Respiratory Drug Delivery
- Sinusitis and nasal conditions
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
The University of Texas at Dallas
2018-2024
University of South Australia
2015-2023
United States Food and Drug Administration
2021-2022
Center for Devices and Radiological Health
2021
Oak Ridge Associated Universities
2021
Oak Ridge Institute for Science and Education
2021
Office of Science
2021
Johnson University
2015
Rutgers, The State University of New Jersey
2015
Dalhousie University
2013
Significance Alzheimer’s disease (AD) is a devastating that results in the progressive cognitive deficits of elderly and has become one major social economic burdens worldwide. There no effective drug or therapy to prevent halt dysfunctions due complex mechanisms such as accumulation amyloid-β (Aβ), increase oxidative stress, formation neurofibrillary tangle drive development disease. We found here Edaravone, been used for ischemic stroke, able treat AD by targeting multiple pathways...
With the ever-growing demand for renewable energy sources, harvesting from natural resources has gained much attention. Energy sources such as heat and mechanical motion could be easily harvested based on pyroelectric, thermoelectric, piezoelectric effects. The otherwise wasted in environment can utilized self-powered micro nano devices, wearable electronics, which required only µW–mW power. This article reviews pyroelectric with an emphasis recent developments devices at micro/nanoscale....
Transimination reactions are highly effective dynamic covalent to enable reprocessability in thermosets, as they can undergo exchange without the need for catalysts, by exposing materials external stimuli such heat. In this work, a series of five biobased vanillin-derived resin formulations consisting vanillin acrylate with methacrylate-functionalized Jeffamines were synthesized and 3D-printed using digital light projection (DLP). The resulting thermosets displayed range mechanical...
Inulin-based hydrogels are useful carriers for the delivery of drugs in colon-targeted system and other biomedical applications. In this project, inulin were fabricated by crosslinking oxidized with adipic acid dihydrazide (AAD) without use a catalyst or initiator. The physicochemical properties obtained further characterized using different techniques, such as swelling experiments, vitro drug release, degradation, biocompatibility tests. was confirmed Fourier transform infrared spectroscopy...
Herpes Simplex Virus Type 2 (HSV-2) is one of the most prevalent sexually transmitted viruses and a known risk factor for HIV acquisition in Female Genital Tract (FGT). Previously, we found that curcumin can block HSV-2 infection abrogate production inflammatory cytokines chemokines by genital epithelial cells vitro. In this study, investigated whether curcumin, encapsulated nanoparticles delivered various vivo routes, could minimize inflammation prevent or reduce FGT. mice were pre-treated...
The solid self-nanoemulsifying drug delivery system (s-SNEDDS) is a growing platform for the of drugs via oral route. In present work, tamoxifen (TAM) was loaded in SNEDDS with resveratrol (RES), which potent chemotherapeutic, antioxidant, anti-inflammatory and P-gp inhibitor enhancing bioavailability to obtain synergistic anti-cancer effect against breast cancer. were developed using capmul MCM as oil, Tween 80 surfactant transcutol-HP co-surfactant optimized by central composite rotatable...
Chronic inflammation and infection of the nasal sinuses, also referred to as Rhinosinusitis (CRS), severely affects patients’ quality life. Adhesions, ostial stenosis, relapses complicate chronic sinusitis treatment strategies. Drug-eluting stents, packings or implants have been suggested reasonable alternatives for addressing these concerns. This article reviewed potential drug candidates implants, formulation methods/optimization characterization methods. Clinical applications important...
We sought to develop a cervical spinal cord stimulator for the rat that is durable, stable, and does not perturb underlying cord.We created softening stimulation (SCS) array made from shape memory polymer (SMP)-based flexible electronics. developed new photolithographic process pattern high surface area titanium nitride (TiN) electrodes onto gold (Au) interconnects. The thiol-ene acrylate polymers are stiff at room temperature soften following implantation into body. Durability was measured...
Abstract 3D printing is a low cost, customizable, and fast‐growing technology with the potential to revolutionize plastic manufacturing. Vat photopolymerization technologies stand out for their high resolution, however, resulting printed materials are made from petroleum feedstocks covalently crosslinked which renders them unrecyclable. Here, resin formulations 70 wt% bio‐based content dynamic functionality synthesized using lignin, vanillin, soybean oil components. These polymers can...
Primary objective: Neurotrophin levels are elevated after TBI, yet there is minimal regeneration. It was hypothesized that the pro-neurotrophin/p75NTR pathway induced more than mature neurotrophin/Trk and interfering with p75 signalling improves recovery following TBI.Research design: Lateral Fluid Percussion (LFP) injury performed on wildtype mutant mice. In addition, TrkB agonist 7,8 Dihydroxyflavone or antagonist TAT-Pep5 were tested. Western blot immunohistochemistry revealed biochemical...
Abstract The additive manufacturing (AM) industry increasingly looks to differentiate itself by utilizing materials and processes that are green, clean, sustainable. Biopolymers, bio‐sourced raw light weighting of parts 3D printed with photopolymer resins each represent critical directions for the future AM. Here, we report a series bio‐based composite soybean oil derivatives, up 20% weight surface‐methacrylated micro‐crystalline cellulose (MCC) 60% total content vat photopolymerization...
Edaravone (EDR) is a well-recognized lipophilic free radical scavenger for diseases including neurodegenerative disease, cardiovascular and cancer. However, its oral use restricted due to poor bioavailability (BA). The aim of present research was enable by developing lipid-based nanosystem (LNS). components LNS oil, surfactants, co-surfactants were selected based on their potential maximize the solubilization in gastrointestinal (GI) fluids, reduce glucuronidation improve transmembrane...
Edaravone (EDR) is known for its free radical scavenging, antiapoptotic, antinecrotic, and anticytokine effects in neurological non-neurological diseases. It currently available clinically as Radicava® Radicut®, intravenous medications, recently approved the treatment of amyotrophic lateral sclerosis cerebral infarction. However, oral use EDR still restricted by poor bioavailability (BA) due to aqueous solubility, stability, rapid metabolism, low permeability. The present study reports...
Delta inulin, also known as microparticulate inulin (MPI), was modified by covalently attaching doxorubicin to its nanostructured surface for use a targeted drug delivery vehicle. MPI is readily endocytosed monocytes, macrophages, and dendritic cells in this study, we sought utilize property develop system target anti-cancer drugs lymphoid organs. We investigated, therefore, whether could be used vehicle deliver selectively, thereby reducing the toxicity of antibiotic anthracycline drug....
Self-expanding metal stents (SEMSs) are currently the gold standard for localised management of malignant gastrointestinal (GI) stenosis and/or obstructions. Despite encouraging clinical success, in-stent restenosis caused by tumour growth is a significant challenge. Incorporating chemotherapeutic drugs into GI an emerging strategy to provide and sustained release intestinal tissues prevent growth. Therefore, aim this work was develop evaluate local stent-based delivery system that provides...
Background: Alzheimer's disease (AD) is a devastating neurodegenerative disorder that lacks any disease-modifying drug for the prevention and treatment. Edaravone (EDR), an approved free radical scavenger, has proven to have potential against AD by targeting multiple key pathologies including amyloid-beta (Aβ), tau phosphorylation, oxidative stress, neuroinflammation. To enable its oral use, novel edaravone formulation (NEF) was previously developed. The aim of present investigation evaluate...
Despite the promising properties of tea tree oil (TTO) as potential therapeutics for several superficial skin conditions, certain limitations such physical instability and irritation have restricted its widespread use. This study focuses on developing a rationally designed lipid-based nanoformulation (TTO-LNF) in accordance with US Food Drug Administration standard using well-recognized quality-by-design (QbD) approach. Using mixture experimental design, TTO-LNF has been optimized 5% TTO,...
3D printing technologies can address many sustainability aspects of creating new materials, such as reduced waste and on demand production, which reduces the carbon footprint transport storage.