A5043662614- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Pomegranate: compositions and health benefits
- Biochemical effects in animals
- Curcumin's Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Systemic Lupus Erythematosus Research
- Advanced Drug Delivery Systems
- Pain Mechanisms and Treatments
- Advancements in Transdermal Drug Delivery
- Retinal Diseases and Treatments
- Ubiquitin and proteasome pathways
- Chemotherapy-induced organ toxicity mitigation
- Sesame and Sesamin Research
- Heat shock proteins research
- Antioxidant Activity and Oxidative Stress
- Chronic Kidney Disease and Diabetes
- Supramolecular Chemistry and Complexes
- Supramolecular Self-Assembly in Materials
- Pancreatic function and diabetes
- Cancer Treatment and Pharmacology
- RNA Interference and Gene Delivery
- Carbohydrate Chemistry and Synthesis
- Retinopathy of Prematurity Studies
- Connexins and lens biology
University of Alabama
2021-2025
Baylor College of Medicine
2023
University of Houston
2023
University of Alabama at Birmingham
2023
Texas A&M University
2017-2022
Texas A&M Health Science Center
2016-2021
College Station Medical Center
2019
Institute of Rural Management Anand
2019
Mitchell Institute
2019
National Institute of Nutrition
2013-2018
Curcumin, the active principle present in yellow spice turmeric, has been shown to exhibit various pharmacological actions such as antioxidant, anti-inflammatory, antimicrobial, and anti-carcinogenic activities. Previously we have reported that dietary curcumin delays diabetes-induced cataract rats. However, low peroral bioavailability is a major limiting factor for success of clinical utilization curcumin. In this study, administered encapsulated nanoparticles streptozotocin (STZ) induced...
Background and Purpose Approaches to prevent selective progressive loss of insulin‐producing beta cells in Type 1 diabetes mellitus (T1DM) will help manage this prevalent devastating disease. Curcumin (CUR), a natural anti‐inflammatory substance, suppresses diabetes‐associated inflammation cell death. However, very high doses need be used because poor oral bioavailability, making it difficult translate the actions clinical situations. Experimental Approach We have prepared biodegradable...
A non-invasive, sustained release, polymeric nanoparticulate drug delivery system offers high retinal bioavailability so as to enable treatment of complications effectively.
Therapeutic interventions that counter emerging targets in diabetes eye diseases are lacking. We hypothesize a combination therapy targeting inflammation and hyperglycemia can prevent diabetic diseases. Here, we report multipronged approach to cataracts retinopathy by combining orally bioavailable curcumin-laden double-headed (two molecules of gambogic acid conjugated terminal carboxyl groups poly(d,l-lactide-co-glycolide)) nanoparticles injectable basal insulin. The treatment led...
Herpes Simplex Virus Type 2 (HSV-2) is one of the most prevalent sexually transmitted viruses and a known risk factor for HIV acquisition in Female Genital Tract (FGT). Previously, we found that curcumin can block HSV-2 infection abrogate production inflammatory cytokines chemokines by genital epithelial cells vitro. In this study, investigated whether curcumin, encapsulated nanoparticles delivered various vivo routes, could minimize inflammation prevent or reduce FGT. mice were pre-treated...
The popular anticancer drug cisplatin causes many adverse side effects, the most serious of which is acute kidney injury (AKI). Emerging evidence from laboratory and clinical studies suggests that AKI pathogenesis involves oxidative stress pathways; therefore, regulating such pathways may offer protection. Urolithin A (UA), a gut metabolite dietary tannin ellagic acid, possesses antioxidant properties has shown promise in mouse models AKI. However, therapeutic potential UA constrained by...
Small heat shock proteins (sHsps) have a critical role under stress conditions to maintain cellular homeostasis by their involvement in protein-folding and cytoprotection. The hyperglycemia diabetes may impose on the retina. Therefore, we investigated expression of sHsps, phosphoregulation αB-crystallin (αBC), localization diabetic rat retina.Diabetes was induced rats maintained for period 12 weeks. HSFs, phosphorylated sHsps analyzed quantitative (q) RT-PCR immunoblotting. solubility...
Cumulative kidney toxicity associated with cisplatin is severe and there no clear consensus on the therapeutic management of same. The pathogenesis involves activation inflammatory apoptotic pathways; therefore, regulating these pathways offers protection. Given anti-inflammatory antioxidant effects urolithin A, a gut microbial metabolite ellagic acid, our aim was to explore potential use A in prevention cisplatin-induced nephrotoxicity an experimental rat model. For this purpose, animals...
The formation of advanced glycation end products (AGEs) is a characteristic feature diabetic tissues and accumulation AGEs been implicated in the pathogenesis nephropathy (DN). Ellagic acid prevented turn ameliorated proteinurea rats.
Orally delivered lymphatic system–specific nanoparticle cyclosporine is an effective way to treat lupus.
In the past decade, liquid chromatography–mass spectrometry (LC-MS/MS) has become pivotal in clinical diagnosis, drug discovery, and bioanalytical science due to its high sensitivity rapid analysis. We have developed an ultrasensitive robust LC-MS/MS method for simultaneous detection quantification of cyclosporine A (CsA) urolithin (UA) employing ascomycin (ASC) naringenin (NAR) as internal standards (ISTDs). The was validated use, revealing interspecies differences between human plasma...
Aberrant activation of oncogenic signaling pathways plays a central role in tumor development and progression. The aim this present study was to investigate the chemopreventive effects neem limonoid gedunin hamster model oral cancer based on its ability modulate aldose reductase (AR), phosphatidyl inositol-3-kinase (PI3K)/Akt, nuclear factor kappa B (NF-κB) block angiogenesis. Administration suppressed HBP carcinomas by inhibiting PI3K/Akt NF-κB through inactivation Akt inhibitory kinase...
Receptor-mediated polyester drug delivery systems have tremendous potential for improving the clinical performance of existing pharmaceutical drugs. Despite significant progress made in this area, it remains unclear how and to what extent nanoparticle surface topography would affect vitro, ex vivo a drug, if there exists correlation between vitro vivo, as well healthy versus pathophysiological states. Herein, we report systematic investigation interactions ligands receptors function linker...
Accumulation of advanced glycation endproducts (AGE) from nonenzymatic proteins has been implicated in several diabetic complications including cataract. Previously, we have reported that extracts dietary agents such as cinnamon the potential to inhibit AGE formation. In this study, shown procyanidin-B2 active component is involved inhibition using bioassay-guided fractionation eye lens under vitro conditions. The data indicate enriched fraction scavenges dicarbonyls. Further, inhibited...
The current methods for targeted drug delivery utilize ligands that must out-compete endogenous in order to bind the active site facilitating transport. To address this limitation, we present a non-competitive transport strategy overcome intestinal barriers form of tunable nanosystems (NS) transferrin receptor (TfR) utilizing gambogic acid (GA), xanthanoid, as its ligand. NS made using GA conjugated poly(lactide-co-glycolide) (PLGA) have shown affinity TfR evaluated cell/cell-free systems....
The success of receptor-mediated drug delivery primarily depends on the ability to optimize ligand–receptor stoichiometry. Conventional polyesters such as polylactide (PLA) or its copolymer, polylactide-co-glycolide (PLGA), do not allow optimization due their terminal functionality. We herein report synthesis 12 variations PLA–poly(ethylene glycol) (PEG) based precision-polyester (P2s) platform, permitting 5–12 periodically spaced carboxyl functional groups polymer backbone. These were...
Novel approaches circumventing blood-ocular barriers in systemic drug delivery are lacking. We hypothesize receptor-mediated of curcumin (CUR) across intestinal and ocular leads to decreased inflammation a model lens-induced uveitis. CUR was encapsulated double-headed polyester nanoparticles using gambogic acid (GA)-coupled polylactide-co-glycolide (PLGA). Orally administered PLGA-GA2-CUR led notable aqueous humor levels dosed (10 mg/kg twice daily) adult male beagles (n = 8 eyes) with...