A5018164154- Garlic and Onion Studies
- Genomics, phytochemicals, and oxidative stress
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Insect Pest Control Strategies
- Phytochemical compounds biological activities
- Tea Polyphenols and Effects
- Carcinogens and Genotoxicity Assessment
- Glutathione Transferases and Polymorphisms
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Curcumin's Biomedical Applications
- Chemotherapy-induced organ toxicity mitigation
- Natural product bioactivities and synthesis
- Estrogen and related hormone effects
- Free Radicals and Antioxidants
- Phytochemicals and Medicinal Plants
- Wnt/β-catenin signaling in development and cancer
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Tannin, Tannase and Anticancer Activities
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Food Science and Nutritional Studies
Annamalai University
2015-2024
Centre For Human Genetics
2024
World Health Organization - India
2024
Tufts University
2019
Jean Mayer Human Nutrition Research Center on Aging
2019
University of Miami
2019
Sichuan University
2012
Cancer Institute (WIA)
1987-1988
Oral squamous cell carcinoma, the fifth most common cancer worldwide, is a major cause of morbidity and mortality in India. The effect lifestyle factors, including tobacco chewing, smoking alcohol drinking, diet dental care, on risk oral was investigated case-control study conducted Rajah Muthiah Dental College Hospital, Annamalainagar, Annamalai University, Chidambaram, Tamil Nadu, India during period 1991-2003. included 388 carcinoma cases an equal number (388) age sex-matched controls....
Identifying agents that inhibit STAT-3, a cytosolic transcription factor involved in the activation of various genes implicated tumour progression is promising strategy for cancer chemoprevention. In present study, we investigated effect dietary astaxanthin on JAK-2/STAT-3 signaling 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model by examining mRNA and protein expression JAK/STAT-3 its target genes. Quantitative RT-PCR, immunoblotting...
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a potent inhibitor of matrix metalloproteinases (MMPs) is common negative target oncogenic signals and potential therapeutic for novel drug development. Here, we show that sequential RECKlessness stimulates angiogenesis Notch signalling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model, paradigm oral oncogenesis chemointervention. We also report chemotherapeutic effect...
Limonoids from the neem tree (Azadirachta indica) have attracted considerable research attention in recent years owing to their potent antioxidant and anti-proliferative effects. The present study was designed investigate cellular molecular mechanisms by which azadirachtin nimbolide exert cytotoxic effects human cervical cancer (HeLa) cell line. Both significantly suppressed viability of HeLa cells a dose-dependent manner inducing cycle arrest at G0/G1 phase accompanied p53-dependent p21...
Abstract Of late, nimbolide, a limonoid from the neem tree ( Azadirachta indica ) has gained increasing research attention owing to its potent antiproliferative and apoptosis-inducing effects. The present study was designed investigate effect of nimbolide on autophagy time point at which phosphorylation status GSK-3β PI3K dictate choice between apoptosis in SCC131 SCC4 oral cancer cells. Additionally, we analysed changes expression proteins involved after therapeutic intervention with...
The neem tree has attracted considerable research attention as a rich source of limonoids that have potent antioxidant and anti-cancer properties. present study was designed to evaluate the chemopreventive potential azadirachtin nimbolide based on in vitro assays vivo inhibitory effects 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. Both exhibited concentration-dependent anti-radical scavenging activity reductive order: > ascorbate. Administration...
Abstract Epidemiological studies have consistently demonstrated the protective effects of dietary phytochemicals against cancer risk. Quercetin, a ubiquitous flavonoid, has attracted considerable attention owing to its potent antioxidant and antiproliferative activities. The present study was designed investigate chemopreventive as well therapeutic ability quercetin modulate key hallmark capabilities 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinomas. We...