A5101947572- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Atherosclerosis and Cardiovascular Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Dementia and Cognitive Impairment Research
- Neurogenesis and neuroplasticity mechanisms
- S100 Proteins and Annexins
- Biochemical effects in animals
- Biochemical Analysis and Sensing Techniques
- Nerve injury and regeneration
- Cholinesterase and Neurodegenerative Diseases
- Aerogels and thermal insulation
- Cancer Cells and Metastasis
- Whipple's Disease and Interleukins
- Amyotrophic Lateral Sclerosis Research
- Inflammation biomarkers and pathways
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Eosinophilic Esophagitis
- Antiplatelet Therapy and Cardiovascular Diseases
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2020-2025
University of Electronic Science and Technology of China
2020-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2025
Shanghai University of Traditional Chinese Medicine
2025
Yan'an University
2024
Panyu District Central Hospital
2024
Southwest Jiaotong University
2024
Army Medical University
2014-2023
Daping Hospital
2014-2023
Shanghai Medical College of Fudan University
2023
Background and purpose Previous studies suggested that the overall burden of prior infections contributes to cardiovascular diseases stroke. In present study, association between infectious ( IB ) Alzheimer's disease AD was examined. Methods Antibody titers common pathogens including cytomegalovirus CMV ), herpes simplex virus type 1 HSV ‐1), B orrelia burgdorferi , C hlamydophila pneumoniae H elicobacter pylori were measured by enzyme‐linked immunosorbent assay in 128 patients 135 healthy...
Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). The physiological capacity peripheral tissues and organs clearing brain-derived Aβ its therapeutic potential for AD remains largely unknown. Here, we measured blood levels different locations circulation humans mice, used parabiosis model to investigate effect catabolism on pathogenesis. We found that inferior/posterior vena cava were lower than superior both mice. In addition, injected 125I labeled Aβ40...
Significance Alzheimer’s disease (AD) is a devastating that results in the progressive cognitive deficits of elderly and has become one major social economic burdens worldwide. There no effective drug or therapy to prevent halt dysfunctions due complex mechanisms such as accumulation amyloid-β (Aβ), increase oxidative stress, formation neurofibrillary tangle drive development disease. We found here Edaravone, been used for ischemic stroke, able treat AD by targeting multiple pathways...
Alzheimer's disease (AD) is the most common cause of age-related dementia and currently incurable. The failures current clinical trials establishment modifiable risk factors have shifted AD intervention from treatment to prevention in at-risk population. Previous studies suggest that there a geographic overlap between incidence spicy food consumption. We previously reported capsaicin-rich diet consumption was associated with better cognition lower serum Amyloid-beta (Aβ) levels people aged...
Background: Capsaicin-rich diets are common worldwide. Capsaicin has been shown to have favorable effects on various diseases including atherosclerosis, cardiovascular diseases, stroke, obesity, hypertension, cancer, and gastrointestinal inflammatory diseases. The impact of capsaicin Alzheim er's disease (AD), which is the most form dementia in elderly, remains unknown. Objective: To investigate correlations intake with cognition blood markers AD. Methods: A total 338 participants aged 40...
Background and Aims: Endovascular treatment (EVT) alone has been confirmed to be non-inferior intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due large-vessel occlusion of the anterior circulation. This trial aims investigate efficacy safety or without IVT AIS basilar artery (BAO). Methods Design: The BEST-BAO is an investigator-initiated, multicenter, prospective, randomized controlled design. Three hundred forty eligible patients from planned 115 centers...
First-pass effect (FPE) is crucial for better outcomes in mechanical thrombectomy (MT) acute large vessel occlusions. However, its frequency and predictors vertebrobasilar artery occlusion (VBAO) remain unclear. To conduct a comprehensive systematic review meta-analysis to assess the incidence of FPE MT VBAO impact on key clinical outcomes. Additionally, explore potential achieving FPE, addressing critical knowledge gaps providing evidence optimize treatment strategies patients with VBAO. A...
Introduction The nutritional level of the diet plays a crucial role in maintaining balance yak rumen microbiota. To explore relationship between dietary levels, microbiota, and muscle metabolites, we examined characteristics microbiota metabolome under different levels. Methods Randomly divide 24 yaks with similar body weights, [235.96 ± 12.46 kg], into three groups. These groups were subjected to feeding levels: ad libitum (AL), 70% intake (IR70), 40% (IR40). When AL group gained 70 kg...
Abstract The expression of miR-143/miR-145 was up-regulated in ischemic stroke (IS), which may be used as biomarkers and/or therapeutic targets for IS. We aimed to investigate the association rs4705342 and rs4705343 polymorphisms promoter miR-143/145 with risk study population comprised 445 patients IS 518 controls. genotype analyzed by using a TaqMan Assay determined polymerase chain reaction-restriction fragment length polymorphism assay. Relative measured quantitative real-time PCR. found...
Increased levels of C-reactive protein (CRP) have been considered as a marker in assessing neurogenic inflammation migraine patients. An inverse relationship between serum bilirubin and CRP has observed various diseases. Therefore, we analyzed patients, investigated the migraineurs.A total 86 newly diagnosed patients were consecutively recruited to this study.Significantly lower median bilirubin, conjugated (CB) unconjugated found with than healthy controls, significantly higher controls. A...