A5003516733- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Cerebrovascular and genetic disorders
- Nerve injury and regeneration
- Cholinesterase and Neurodegenerative Diseases
- Circadian rhythm and melatonin
- Gut microbiota and health
- Cardiac Ischemia and Reperfusion
- Tryptophan and brain disorders
- Cell Adhesion Molecules Research
- Neurological Disease Mechanisms and Treatments
- Kruppel-like factors research
- Advanced Nanomaterials in Catalysis
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Polysaccharides and Plant Cell Walls
- Cellular Mechanics and Interactions
- Advanced Glycation End Products research
- Congenital heart defects research
- Clinical Nutrition and Gastroenterology
- Cardiovascular Function and Risk Factors
Army Medical University
2017-2025
Daping Hospital
2019-2025
Southwest Hospital
2021-2025
Tianjin Medical University
2021-2024
Tongde Hospital of Zhejiang Province
2024
Heilongjiang Bayi Agricultural University
2023
University of the Sciences
2012
Abstract Background Time-restricted feeding is an emerging dietary intervention that becoming increasingly popular. There are, however, no randomised clinical trials of time-restricted in overweight patients with type 2 diabetes. Here, we explored the effects on glycaemic regulation and weight changes diabetes over 12 weeks. Methods Overweight adults (n = 120) were 1:1 to two diet groups: 60) or control 60). Sixty participated a 10-h restricted treatment program (ad libitum from 8:00 18:00...
Alzheimer's disease (AD) is the most common cause of age-related dementia and currently incurable. The failures current clinical trials establishment modifiable risk factors have shifted AD intervention from treatment to prevention in at-risk population. Previous studies suggest that there a geographic overlap between incidence spicy food consumption. We previously reported capsaicin-rich diet consumption was associated with better cognition lower serum Amyloid-beta (Aβ) levels people aged...
Abstract Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role pathogenesis sporadic Alzheimer’s disease (AD). The roles blood monocytes development AD remain unclear. In this study, we sought to investigate alterations Aβ phagocytosis function peripheral during ageing and patients. A total 104 cognitively normal participants aged 22–89 years, 24 patients, 25 age- sex-matched (CN) subjects, 15 Parkinson’s patients (PD), CN subjects were recruited. uptake by was measured its...
Emerging evidence suggests that gut microbiota dysbiosis plays a role in neurodegenerative disorders. However, whether the composition and diversity of are altered tauopathies remains largely unknown. This study was aimed to examine tauopathies, as well correlation with pathological changes brain. We collected fecal samples from 32 P301L tau transgenic mice age- gender-matched littermate at different ages. The 16S ribosomal RNA sequencing technique used analyze feces. Brain pathology levels...
Brain amyloid-β (Aβ) deposition is a hallmark to define Alzheimer's disease (AD). We investigated the positive rate of brain amyloid assessed with 11C-Pittsburgh compound (PiB)-PET and blood Aβ levels in cohort probable AD patients who were diagnosed according 1984 NINCDS-ADR DA criteria. Eighty-four subjects clinical diagnosis dementia, amnestic mild cognitive impairment (MCI), cognitively normal (CN) status subjected PiB-PET 18F-fluorodeoxyglucose (FDG)-PET scans. Plasma biomarkers Aβ42,...
Background/Aims: Neointimal hyperplasia is responsible for stenosis, which requires corrective vascular surgery, and also a major morphological feature of many cardiovascular diseases. This involves the endothelial-to-mesenchymal transition (EndMT). We investigated whether integrin β3 can modulate EndMT, as well its underlying mechanism. Methods: Integrin was overexpressed or knocked down in human umbilical vein endothelial cells (HUVECs). The expression markers mesenchymal determined by...
ABSTRACT Revealing the temporal evolution of cerebrospinal fluid (CSF) biomarkers during aging is critical to understanding disease pathogenesis and developing early diagnoses interventions for Alzheimer's (AD). CSF was obtained from 549 cognitively normal subjects between 18 93 years age. 12 AD‐related were evaluated, including amyloid β (Aβ42, Aβ40, Aβ42/Aβ40 ratio), hyperphosphorylated tau (P‐tau), neuronal injury/degeneration (T‐tau, NFL, NSE, H‐FABP, VILIP‐1), neuroinflammation (YKL‐40,...
Diabetic kidney disease (DKD) progression can be predicted by abnormalities in the tubulointerstitial lining, and their treatment may useful for preventing disease. DKD is a progressive that contributes to renal tubular cell death, but its underlying mechanisms remain unclear. Ferroptosis novel term linked lipid hydroperoxidation, it plays an important role pathogenesis of DKD. Overexpression cyclooxygenase-2 (COX2), enzyme proximal tubule, causes cellular redox damage It remains unknown...
Heat shock transcription factors (Hsf) are pivotal as essential factors. They function direct transcriptional activators of genes regulated by thermal stress and closely associated with various abiotic stresses. Asparagus (Asparagus officinalis) is a vegetable considerable economic nutritional significance, abundant in vitamins, minerals, dietary fiber. Nevertheless, asparagus sensitive to environmental stresses, specific stresses harm its yield quality. In this context, Hsf members have...
Recent studies suggest that a healthy diet helps to prevent the development of Alzheimer disease (AD). This study aimed investigate whether spicy food consumption is associated with cognition and cerebrospinal fluid (CSF) biomarkers AD in Chinese population.We enrolled 55 patients age- gender-matched cognitively normal (CN) subjects case-control study, as well cohort 131 participants without subjective cognitive decline (non-AD) cross-sectional study. Spicy was assessed using Food Frequency...