A5043545090- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Tuberculosis Research and Epidemiology
- Job Satisfaction and Organizational Behavior
- Mycobacterium research and diagnosis
- Multilevel Inverters and Converters
- Medical Imaging Techniques and Applications
- Psychosocial Factors Impacting Youth
- Ammonia Synthesis and Nitrogen Reduction
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Chemical Sensor Technologies
- Robotics and Sensor-Based Localization
- Meat and Animal Product Quality
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Induction Heating and Inverter Technology
- Tryptophan and brain disorders
- Robotic Path Planning Algorithms
- Diagnosis and treatment of tuberculosis
- Memory and Neural Mechanisms
Beijing Jiaotong University
2024-2025
Shenzhen Bay Laboratory
2021-2025
Peking University
2022-2025
First Affiliated Hospital of Henan University of Science and Technology
2018-2025
Peking University Shenzhen Hospital
2024-2025
Guangdong Polytechnic Normal University
2022-2024
Sun Yat-sen University
2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2015-2024
Shanghai East Hospital
2024
Drawing on spiritual leadership theory and intrinsic motivation theory, we proposed a homologous multilevel model to explore the effectiveness of employees' task performance, knowledge sharing behaviors innovation at individual level. With questionnaires rated by 306 pairs employees their supervisors in 26 teams from energy industry mainland China, conduct analysis examine our hypotheses. The results show that was positively related employee behavior, when controlled for possible confounding...
Abstract The present study examined whether having a positive reputation to maintain makes young children less likely cheat. Cheating was assessed through temptation resistance paradigm in which participants were instructed not cheat guessing game. Across three studies (total N = 361), preschool‐aged randomly assigned either condition, an experimenter told them that she had learned of their from classmates, or control condition they received no such information. By age 5, the cheated often...
<h3>Objective</h3> To examine the feasibility of using cross-sectional PET to identify cognitive decliners among β-amyloid (Aβ)-negative cognitively normal (CN) elderly adults. <h3>Methods</h3> We determined highest Aβ-affected region by ranking baseline and accumulation rates florbetapir-PET regions in 355 CN adults <sup>18</sup>F-florbetapir-PET from Alzheimer9s Disease Neuroimaging Initiative (ADNI). The banks superior temporal sulcus (BANKSSTS) were found as region, Aβ positivity this...
Abstract Introduction The Guangdong-Hong Kong-Macao Greater-Bay-Area of South China has an 86 million population and faces a significant challenge Alzheimer’s disease (AD). However, the characteristics prevalence AD in this area are still unclear due to rarely available community-based neuroimaging cohort. Methods Following standard protocols Disease Neuroimaging Initiative, Healthy Aging Brain Study (GHABS) was initiated 2021. GHABS participants completed clinical assessments, plasma...
Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling relevant failure play a key role the pathophysiological mechanism of Alzheimer's disease (AD).
We applied a low-intensity pulsed transcranial ultrasound stimulation (pTUS) to the ischemic cortex after distal middle cerebral artery occlusion (dMCAO) study whether pTUS is capable of protecting brain from injury.Rats were randomly assigned Sham (n = 6), Control 16), and 16) groups. The pTUS-treated rats subjected 60-min ultrasonic immediately ischemia. After 48 h, sensorimotor-related behavioral outcomes assessed by neurological severity score (NSS), permanent injury was histologic...
One of the most prevalent chronic diseases, osteoarthritis (OA), may work in conjunction with
Abstract Background To better assist with the design of future clinical trials for Alzheimer’s disease (AD) and aid in our understanding disease’s symptomatology, it is essential to clarify what roles β-amyloid (Aβ) plaques tau tangles play longitudinal accumulation inside outside medial temporal lobe (MTL) as well how age, sex, apolipoprotein E (APOE) ε4 (APOE-ε4), Klotho-VS heterozygosity (KL-VS het ) modulate these relationships. Methods We divided 325 Aβ PET-positive (A+) participants...
Plasma β-amyloid
Abstract Background It is not fully established whether plasma β-amyloid(Aβ) 42 /Aβ 40 and phosphorylated Tau 181 (p-Tau ) can effectively detect Alzheimer’s disease (AD) pathophysiology in older Chinese adults how these biomarkers correlate with astrocyte reactivity, Aβ plaque deposition, tau tangle aggregation, neurodegeneration. Methods We recruited 470 analyzed , p-Tau glial fibrillary acidic protein (GFAP), neurofilament light (NfL) using the Simoa platform. Among them, 301, 195, 70...
Triggering receptor expressed on myeloid cells-2 (TREM2) and progranulin (PGRN) are critical regulators of microglia activation can be detected in cerebrospinal fluid (CSF). However, whether microglial reactivity is detrimental or neuroprotective for Alzheimer disease (AD) still debatable.
To explore the complementary relationship between magnetic resonance imaging (MRI) radiomic and plasma biomarkers in early diagnosis conversion prediction of Alzheimer’s disease (AD), our study aims to develop an innovative multivariable model that integrates those two for predicting results AD. This longitudinal multicentric cohort included 2 independent cohorts: Sino Longitudinal Study on Cognitive Decline (SILCODE) project Alzheimer Disease Neuroimaging Initiative (ADNI). We collected...
Abstract Background Alzheimer’s disease (AD)-related tauopathy can be measured with CSF phosphorylated tau (pTau) and PET. We aim to investigate the associations between these measurements their relative ability predict subsequent progression. Methods In 219 cognitively unimpaired 122 impaired Disease Neuroimaging Initiative participants concurrent amyloid-β (Aβ) PET ( 18 F-florbetapir or F-florbetaben), F-flortaucipir (FTP) PET, measurements, structural MRI, cognition, we examined...
Increased presynaptic dysfunction measured by cerebrospinal fluid (CSF) growth-associated protein-43 (GAP43) may be observed in Alzheimer's disease (AD), but how CSF GAP43 increases relate to AD-core pathologies, neurodegeneration, and cognitive decline AD requires further investigation.We analyzed 731 older adults with baseline β-amyloid (Aβ) positron emission tomography (PET), GAP43, phosphorylated tau181 (p-Tau181 ), 18 F-fluorodeoxyglucose PET, longitudinal residual hippocampal volume...
Abstract INTRODUCTION Subjective cognitive decline (SCD) in amyloid‐positive (Aβ+) individuals was proposed as a clinical indicator of Stage 2 the Alzheimer's disease (AD) continuum, but this requires further validation across cultures, measures, and recruitment strategies. METHODS Eight hundred twenty‐one participants from SILCODE DELCODE cohorts, including normal controls (NC) with SCD recruited community or memory clinics, underwent neuropsychological assessments over up to 6 years....
<h3>Objective</h3> To compare CSF β-amyloid (Aβ) and florbetapir PET measurements in cognitively unimpaired (CU) elderly adults order to detect the earliest abnormalities their predictive effect for cognitive decline. <h3>Methods</h3> A total of 259 CU individuals were categorized as abnormal (+) or normal (−) on Aβ<sub>1-42</sub>/Aβ<sub>1-40</sub> analyzed with mass spectrometry Aβ measured <sup>18</sup>F-florbetapir. Simultaneous longitudinal compared 39 who unambiguously Aβ-negative at...