A5100533248- Alzheimer's disease research and treatments
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Computational Drug Discovery Methods
- COVID-19 diagnosis using AI
- AI in cancer detection
- Cancer, Lipids, and Metabolism
- Neuroscience and Neuropharmacology Research
- SARS-CoV-2 and COVID-19 Research
- Machine Learning in Materials Science
- Dementia and Cognitive Impairment Research
- Lipid metabolism and biosynthesis
- Artificial Intelligence in Healthcare
- Memory and Neural Mechanisms
- Diet and metabolism studies
- Circadian rhythm and melatonin
- Machine Learning in Healthcare
- RNA modifications and cancer
- SARS-CoV-2 detection and testing
- Microbial Community Ecology and Physiology
- Corporate Social Responsibility Reporting
- Circular RNAs in diseases
- Mathematical Biology Tumor Growth
- Moringa oleifera research and applications
Shanghai East Hospital
2024-2025
Hainan University
2025
Nantong University
2024
Ocean University of China
2024
Anhui University
2024
Qilu University of Technology
2023-2024
Feed Research Institute
2024
Ministry of Agriculture and Rural Affairs
2024
Tsinghua University
2023-2024
Zhejiang University of Technology
2024
The AI-based small molecule drug discovery has become a significant trend at the intersection of computer science and life sciences. In pursuit novel compounds, fragment-based emerged as approach. Generative Pre-trained Transformers (GPT) model showcased remarkable prowess across various domains, rooted in its pre-training representation learning fundamental linguistic units. Analogous to natural language, molecular encoding, form chemical necessitates fragmentation aligned with specific...
Abstract INTRODUCTION We aimed to investigate the effect of apolipoprotein E4 ( APOE) ε4 on synaptic density in cognitively impaired (CI) participants. METHODS One hundred ten CI participants underwent amyloid positron emission tomography (PET) with 18 F‐florbetapir and PET F‐SynVesT‐1. evaluated influence APOE allele investigated effects genotype associations Alzheimer's disease (AD) biomarkers. The mediation AD biomarkers ε4‐associated loss were analyzed. RESULTS Compared non‐carriers,...
Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling relevant failure play a key role the initial pathophysiological mechanism of Alzheimer's disease (AD). The study aims to investigate association between availability AD's biomarkers cognitive function.
Abstract Large dark current at room temperature has long been the major bottleneck that impedes development of high‐performance infrared photodetectors toward miniaturization and integration. Although based on layered 2D narrow bandgap semiconductors have shown admirable advantages compared with those conventional compounds, which typically suffer from expensive cryogenic operation, it is still urgent to develop a simple but effective strategy further reduce current. Herein, tellurium...
Abstract INTRODUCTION To investigate the associations of metabotropic glutamate receptor 5 (mGluR5) with tau deposition and cognitive ability in patients early Alzheimer's disease (AD). METHODS Twenty‐six cognitively impaired (CI) 14 unimpaired (CU) individuals underwent mGluR5 positron emission tomography (PET) ([ 18 F]PSS232), amyloid PET F]florbetapir), F]MK6240), neuropsychological assessment. The relationships among availability, deposition, assessment were analyzed using Spearman's...
Lactiplantibacillus pentosus 292 is a lactic acid bacterium (LAB) with significant probiotic potential, but large-scale production often limited by high costs and preservation challenges. This study aimed to develop cost-effective medium enhance establish feasible strategy support the strain's application. A low-cost containing glucose, yeast powder, K₂HPO₄, Tween-80 was formulated, enabling achieve yield of 16.24 g/L, representing an 83.48% increase compared traditional MRS medium....
Disturbed sleep is closely associated with an increased risk of metabolic diseases. However, the underlying mechanisms circadian clock genes linking and lipid profile abnormalities have not been fully elucidated. This study aimed to explore important role in regulating impaired cholesterol metabolism at early stage deprivation (SD). Sleep disturbance was conducted using SD instrument. Our results showed that serum levels. Concentrations leptin resistin were much lower after SD, but other...
Impaired social interaction is one of the core deficits autism spectrum disorder (ASD) and may result from interactions being less rewarding. How nucleus accumbens (NAc), as a key hub reward circuitry, encodes whether these representations are altered in ASD remain poorly understood. We identified NAc ensembles encoding by calcium imaging using miniaturized microscopy. population activity, specifically D1 receptor-expressing medium spiny neurons (D1-MSNs) predicted epochs. Despite high...
Cerebral ischemia-reperfusion injury (CIRI) is one of the most difficult challenges in cerebrovascular disease research. It primarily caused by excessive autophagy induced oxidative stress. Previously, a novel compound X5 was found, and excellent antioxidant activity it verified this study. Moreover, network pharmacological analysis suggested that closely associated with mTOR pathway.
Abstract Background: Epilepsy is a common neurological disorder that affects approximately 60 million people worldwide. Characterized by unpredictable neural electrical activity abnormalities, it results in seizures with varying intensity levels. Electroencephalography (EEG), as crucial technology for monitoring and predicting epileptic seizures, plays an essential role improving the quality of life epilepsy. Method: This study introduces innovative deep learning model, lightweight triscale...
The roles of low molecular mass polypeptide 2 (LMP2) and transporter-associated with antigen processing (TAP2) in tumorigenesis are controversial. Here we aimed to explore the effect LMP2 TAP2 on oncogenesis metastasis cervical cancer cells.The expressions normal tissues were determined by qPCR. Plate colony formation, cell counting kit-8 analysis vivo tumor xenograft assays used detect growth. Wound healing transwell cancer. Gelatin zymography western blotting EMT Wnt/β-catenin pathway...
Existing formats based on the simplified molecular input line entry system (SMILES) encoding and graph structure are designed to encode complete semantic structural information of molecules. However, physicochemical properties molecules complex, a single features from SMILES sequences or structures cannot adequately represent information. Aiming address this problem, study proposes sequence cross-attention (SG-ATT) representation architecture for property prediction model efficiently use...
The purpose of this study was to investigate the effects dietary supplementation compound probiotics on performance, egg quality, biochemical parameters and intestinal morphology laying hens. A total 180 healthy 200-day-old Hyline Brown hens with similar initial rate (87.5% ± 0.2%) were randomly divided into control group treatment group. Each included 6 replicates each replicate 15 provided a basal diet, while received diet supplemented probiotics. experiment lasted for 52 days. indicated...
Abstract Since the outbreak of COVID-19 corona virus in late 2019, it has become a tremendous threat to whole world. Driven by mission save lives, we develop fever screening and tracing system which can detect patients with symptom, identify using face recognition. In addition, our big data AI platform enables possible. A real-time alert sent personnel on duty web or mobile app activates action trace patient close contacts providing an effective means control spread virus.
High altitudes or exposure to hypoxia leads female reproductive disorders. Circadian clocks are intrinsic time-tracking systems that enable organisms adapt the Earth’s 24-h light/dark cycle, which can be entrained by other environmental stimuli regulate physiological and pathological responses. In this study, we focused on whether ovarian circadian clock proteins were involved in regulating dysfunction under hypoxic conditions. Hypobaric was found induce a significantly prolonged estrous...
To the Editor, Since December 2019, a series of pneumonia cases caused by novel coronavirus have been reported in Wuhan, Hubei Province, China.The soon raised intense attention not only within China but also internationally, and was initially named 2019-nCoV World Health Organization (WHO) [1].Shortly after that, disease renamed WHO as 2019 (COVID-19) virus severe acute respiratory syndrome 2 (SARS-CoV-2) Coronavirus Study Group (CSG) [2,3].Up to March 1, 2020, COVID-2019 has tens thousands...
The beneficial effects of physical exercise on human cardiorespiratory fitness might be through reduced systemic inflammation, but the mechanism remains a controversy. Recent studies have highlighted importance spleen microbiomes in immune regulation. Hence, we conducted study using high-fat diet and mouse model to investigate relationships among different intensities, microbiome composition, cardiac function. mice contained diverse array microbiota. Different intensities resulted varying...
This study aims to investigate the effects of macleaya extract and glucose oxidase combination (MGO) on growth performance, antioxidant capacity, immune function, cecal microbiota in piglets. A total 120 healthy 28-day-old weaned piglets were randomly divided into two treatments six replicates. Piglets either received a basal diet or supplemented with 250 mg/kg MGO (2 g/kg sanguinarine, 1 chelerythrine, × 106 U/kg oxidase). The results showed that supplementation increased average daily gain...