A5100376971- Gut microbiota and health
- Cardiac Health and Mental Health
- Biomedical Text Mining and Ontologies
- Sleep and related disorders
- Traditional Chinese Medicine Analysis
- Gastrointestinal motility and disorders
- Plant Surface Properties and Treatments
- Neural dynamics and brain function
- Epigenetics and DNA Methylation
- Psychedelics and Drug Studies
- Sleep and Wakefulness Research
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Natural Compounds in Disease Treatment
- Biological and pharmacological studies of plants
- Computational Drug Discovery Methods
- Plant biochemistry and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Psoriasis: Treatment and Pathogenesis
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Hearing, Cochlea, Tinnitus, Genetics
- Pharmacogenetics and Drug Metabolism
- Pancreatic and Hepatic Oncology Research
Cancer Research And Biostatistics
2024
Peking University Cancer Hospital
2023-2024
First Hospital of China Medical University
2024
Peking University
2023-2024
China Medical University
2024
Yangzhou University
2023
Nanjing University of Chinese Medicine
2020-2022
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2022
Fire Safety Design
2022
Institute of Navigation
2022
The wide application of immune checkpoint inhibitors has significantly improved the survival expectation cancer patients. While immunotherapy brings benefits to patients, it also results in a series immune-related adverse events (irAEs). Increasing evidence suggests that gut microbiome is critical for response and development irAEs.In this prospective study, we recruited 95 patients with advanced/unresectable gastrointestinal cancers treated report comprehensive analysis association irAEs....
Significance The noise pollution accompanying industrialization is a risk factor to human health. Here, we show in rodent model that even moderate-level at ∼65 dB SPL has little effect on stress status can substantially impair hippocampus-related learning and memory by altering the plasticity of synaptic transmission. It possible because moderately loud does not affect peripheral hearing per se, negative impacts chronic exposure such are currently well characterized. Our results indicate...
Disturbed sleep is closely associated with an increased risk of metabolic diseases. However, the underlying mechanisms circadian clock genes linking and lipid profile abnormalities have not been fully elucidated. This study aimed to explore important role in regulating impaired cholesterol metabolism at early stage deprivation (SD). Sleep disturbance was conducted using SD instrument. Our results showed that serum levels. Concentrations leptin resistin were much lower after SD, but other...
Abstract Background Methamphetamine (MA) abuse has resulted in a plethora of social issues. Sleep disturbance is prominent issue about MA addiction, which serve as risk factor for relapse, and the gut microbiota could play an important role pathophysiological mechanisms sleep disturbances. Therefore, improving quality can be beneficial treating methamphetamine interventions addressing may represent promising approach. Method We recruited 70 users to investigate associations between fecal by...
Abstract Postoperative atrial fibrillation (POAF) is a common complication after coronary artery bypass grafting (CABG) surgery. Gut microbiota and its metabolites have been implicated in the development of AF. However, whether gut–host metabolic interaction contributes to POAF still unknown. This study aimed investigate POAF-associated gut metabolism biomarkers related risk model. The ( N = 30) patients non-POAF 60) from discovery cohort exhibited significantly different microbiome...
This was the first study to determine effect of tanshinone IIA (an active ingredient in herb Danshen) on fetuses utero under unstressed condition. Tanshinone or 0.9% NaCl as control intravenously (i.v.) administrated into pregnant ewes. Both maternal and fetal blood were analyzed for PO 2 , PCO SO %, hemoglobin, hemotecrit, glucose, lactic acid, Na + K Cl - concentrations. Maternal heart functions assessed by examining cardiac enzymes cardiovascular responses. The results showed that did not...
To investigate the differences in intestinal microbiota between diarrhea irritable bowel syndrome mice (IBS‐D) and healthy to explore effects of Jianpi mixture on microbes’ changes IBS‐D based 16S rDNA sequencing analysis. 48 young ICR male were randomly divided into four groups ( n = 12): (1) control group, (2) group fed with distilled water, (3) lactic acid bacteria compound, (4) for 14 days. At end treatment period, 5 selected from each then before after analyzed by high‐throughput gene...
Abstract Background The discovery and therapeutic application of immune checkpoint inhibitors (ICIs) has significantly improved clinical outcomes in cancer treatment. However, the response rate is still low gastrointestinal (GI) cancers. gut microbiome’s impact on modulation a promising area for enhancing ICI efficacy. Methods This study ( NCT04130763 ) an open label, single-arm, single center, phase 1 assessing safety efficacy fecal microbiota transplantation (FMT) from healthy donors ten...
Pharmacogenomics (PGx) holds the promise of personalizing medical treatments based on individual genetic profiles, thereby enhancing drug efficacy and safety. However, current landscape PGx research is hindered by fragmented data sources, time-consuming manual extraction processes, need for comprehensive up-to-date information. This study aims to address these challenges evaluating ability Large Language Models (LLMs), specifically Llama3.1-70B, automate improve accuracy information from FDA...
Abstract Demethylzeylasteral (Dem), the key component of Tripterygium wilfordii Hook F, has been considered to be a traditional Chinese medicine for treatment rheumatic diseases. In this study, mouse colitis model induced by dextran sulfate sodium (DSS) was constructed clarify role Dem in inflammatory bowel (IBD). Our results showed that attenuates symptoms IBD mice, as evidenced shortened colon length and weight loss, accompanied decrease proportion Th17 cells. Moreover, shown inhibit...