A5100358008- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Diabetes and associated disorders
- Bone health and treatments
- Hepatitis C virus research
- Single-cell and spatial transcriptomics
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
- Pharmacological Effects of Natural Compounds
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Analysis
- Alzheimer's disease research and treatments
- Plant-based Medicinal Research
- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Phytochemistry and Biological Activities
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
Shanghai East Hospital
2020-2025
Guardant (United States)
2023-2025
Yunnan University of Traditional Chinese Medicine
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Gansu Provincial Hospital
2024
The University of Texas MD Anderson Cancer Center
2021-2024
Wannan Medical College
2022-2024
Beijing University of Chinese Medicine
2021-2024
First Affiliated Hospital of Wannan Medical College
2024
Peking University Cancer Hospital
2019-2023
Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) essential physiological metabolite from mitochondrial tricarboxylic acid (TCA) cycle, with multiple functions, including anti-inflammation antioxidation, exhibits decreased serum levels age. Herein, we aimed to investigate effect mechanism α-KG on We first quantified in human cartilage tissue osteoarthritic chondrocytes induced by...
Abstract INTRODUCTION We aimed to investigate the effect of apolipoprotein E4 ( APOE) ε4 on synaptic density in cognitively impaired (CI) participants. METHODS One hundred ten CI participants underwent amyloid positron emission tomography (PET) with 18 F‐florbetapir and PET F‐SynVesT‐1. evaluated influence APOE allele investigated effects genotype associations Alzheimer's disease (AD) biomarkers. The mediation AD biomarkers ε4‐associated loss were analyzed. RESULTS Compared non‐carriers,...
Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling relevant failure play a key role the initial pathophysiological mechanism of Alzheimer's disease (AD). The study aims to investigate association between availability AD's biomarkers cognitive function.
Metabolic dysfunction-associated fatty liver disease (MAFLD) affects approximately one-quarter of the world's adult population, and no effective therapeutic drugs are available. Poria cocos is a fungus used as herb food nutrient for centuries well MAFLD treatment. Exosome-like nanovesicles have many pharmacological activities; however, studies on effects cocos-derived exosome-like (PCELNs) lacking. Therefore, our study aimed at identifying mechanism action PCELNs MAFLD. were isolated by...
Oxidative stress and neuroinflammation have been demonstrated to be linked with Alzheimer’s disease (AD). In this study, we examined the protective effects of DL0410 in aging rats explored underlying mechanism against oxidative damage neuroinflammation, which was then validated LPS‐stimulated BV2 microglia. We firstly investigated improvement on learning memory abilities potential mechanisms D‐gal‐induced rats. An 8‐week treatment significantly improved cognitive function D‐gal‐stimulated...
Abstract INTRODUCTION To investigate the associations of metabotropic glutamate receptor 5 (mGluR5) with tau deposition and cognitive ability in patients early Alzheimer's disease (AD). METHODS Twenty‐six cognitively impaired (CI) 14 unimpaired (CU) individuals underwent mGluR5 positron emission tomography (PET) ([ 18 F]PSS232), amyloid PET F]florbetapir), F]MK6240), neuropsychological assessment. The relationships among availability, deposition, assessment were analyzed using Spearman's...
Abstract Introduction: Cell-free DNA (cfDNA) tumor fraction (TF) quantification is an emerging biomarker with many promising applications, including the potential to complement size measurements from imaging. Genomic approaches for TF estimation are limited by presence of cancer driver alterations, detection sensitivity, and may be confounded non-tumor derived variants. Therefore, we have previously developed a method using differentially methylated regions robustly estimate (Chen et al AACR...
Abstract Introduction: Molecular residual disease (MRD) detection via ctDNA analysis refines recurrence risk estimation. Patients with MRD have substantial for metastatic and may genomic biomarkers that could inform treatment. We describe rates of clinically actionable in plasma based on fraction (TF) the post-operative setting. Methods: Positive Guardant Reveal samples were tested using Guardant360. is a tissue-free epigenomic assay quantitation stage II-III colorectal (CRC), breast, lung...
Introduction The progression of Alzheimer's disease (AD) has been shown to significantly correlate with changes in brain tissue structure and leads cognitive decline dementia. Using radiomic features derived from magnetic resonance imaging (MRI) scan, we can get the help deep learning (DL) model for diagnosing AD. Methods This study proposes use DL under framework MR radiomics AD diagnosis. Two cross-racial independent cohorts Disease Neuroimaging Initiative (ADNI) database (141 AD, 166 Mild...
Abstract Introduction: Molecular residual disease (MRD) detection can offer valuable prognostic insights and guide personalized treatment decisions. High sensitivity specificity are required for accurate MRD assessment, with most methods currently relying on tissue sequencing informing assay design. However, testing be logistically challenging not all patients have accessible tissue. Here, we describe the analytical validation of Guardant Reveal plasma-only, epigenomic-based quantification...
Background: It is unclear whether laparoscopic hepatectomy (LH) for hepatolithiasis confers better clinical benefit and lower hospital costs than open (OH). This study aim to evaluate the economic value of LH versus OH. Methods: Patients undergoing OH or primary at Yijishan Hospital Wannan Medical College between 2015 2022 were divided into group group. Propensity score matching (PSM) was used balance baseline data. Deviation-based cost modelling weighted average median (WAMC) assess compare...
Alzheimer’s disease (AD) is a neurodegenerative that seriously threatens the health of elderly. At present, no drugs have been proven to cure or delay progression disease. Due multifactorial aetiology this disease, multi-target-directed ligand (MTDL) approach provides an innovative and promising idea in search for new against AD. In order find potential multi-target anti-AD from traditional Chinese medicine (TCM) formulae, compound database derived herbal formulae was constructed predicted...
Abstract Flubendazole, an FDA‐approved anthelmintic, has been predicted to show strong VEGFR2 inhibitory activity in silico screening combined with vitro experimental validation, and it shown anti‐cancer effects on some human cancer cell lines, but little is known about the anti‐angiogenesis anti‐prostate effects. In this study, we analyzed binding modes kinetic analysis of flubendazole first demonstrated that suppressed VEGF‐stimulated proliferation, wound‐healing migration, invasion tube...
The intricate formation of the palate involves a series complex events, yet its mechanistic basis remains uncertain. To explore major cell populations in and their roles during development, we constructed spatiotemporal transcription landscape palatal cells. Palate samples from C57BL/6 J mice at embryonic days 12.5 (E12.5), 14.5 (E14.5), 16.5 (E16.5) underwent single-cell RNA sequencing (scRNA-seq) to identify distinct subsets. In addition, spatial enhanced resolution omics-sequencing...
SUMMARY Hundreds of small-scale influenza outbreaks in schools are reported mainland China every year, leading to a heavy disease burden which seriously impacts the operation affected schools. Knowing transmissibility each outbreak early stage has become major concern for public health policy-makers and primary healthcare providers. In this study, we collected all Changsha (a large city south central with ~7·04 million population) from January 2005 December 2013. Four simple popularly used...
The aim of this study was to analyze clinical features and short-term mortality in hemodialysis (HD) patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) omicron BA.2.2.1 variant.In a retrospective single-center case series, 102 consecutive hospitalized HD the coronavirus variant were assessed at Pudong Hospital Shanghai, China, from April 6 18, 2022; final date follow-up May 16, 2022. Clinical, laboratory, chest CT, treatment data collected analyzed....