A5101530678- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Animal Virus Infections Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Traditional Chinese Medicine Studies
- Cervical Cancer and HPV Research
- Parkinson's Disease Mechanisms and Treatments
- Immunotherapy and Immune Responses
- Stroke Rehabilitation and Recovery
- Acupuncture Treatment Research Studies
- Artificial Intelligence in Healthcare and Education
- Health, psychology, and well-being
- Angiogenesis and VEGF in Cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Viral Infections and Immunology Research
- interferon and immune responses
- Hepatitis B Virus Studies
- Ovarian function and disorders
- Bone health and osteoporosis research
- Bioactive Compounds in Plants
- Tunneling and Rock Mechanics
- Advanced Glycation End Products research
- Prostate Cancer Treatment and Research
University of Chinese Academy of Sciences
2020-2024
Heilongjiang University of Chinese Medicine
2019-2023
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2019
Xiyuan Hospital
2016-2019
Abstract Introduction The Guangdong-Hong Kong-Macao Greater-Bay-Area of South China has an 86 million population and faces a significant challenge Alzheimer’s disease (AD). However, the characteristics prevalence AD in this area are still unclear due to rarely available community-based neuroimaging cohort. Methods Following standard protocols Disease Neuroimaging Initiative, Healthy Aging Brain Study (GHABS) was initiated 2021. GHABS participants completed clinical assessments, plasma...
Abstract Background It is not fully established whether plasma β-amyloid(Aβ) 42 /Aβ 40 and phosphorylated Tau 181 (p-Tau ) can effectively detect Alzheimer’s disease (AD) pathophysiology in older Chinese adults how these biomarkers correlate with astrocyte reactivity, Aβ plaque deposition, tau tangle aggregation, neurodegeneration. Methods We recruited 470 analyzed , p-Tau glial fibrillary acidic protein (GFAP), neurofilament light (NfL) using the Simoa platform. Among them, 301, 195, 70...
Accurate prediction of tunnel squeezing, one the common geological hazards during construction, is great significance for ensuring construction safety and reducing economic losses. To achieve precise this study constructed six reliable machine learning (ML) classification models purpose, including Support Vector Machine (SVM), Random Forest (RF), Decision Tree (DT), Extreme Gradient Boosting (XGBoost), Light (LGBM), K-Nearest Neighbors (KNN). The parameters these 6 ML were optimized using...
One of the most prevalent chronic diseases, osteoarthritis (OA), may work in conjunction with
Abstract INTRODUCTION Novel fluid biomarkers for tracking neurodegeneration specific to Alzheimer's disease (AD) are greatly needed. METHODS Using two independent well‐characterized cohorts ( n = 881 in total), we investigated the group differences plasma N‐terminal tau (NT1‐tau) fragments across different AD stages and their association with cross‐sectional longitudinal amyloid beta (Aβ) plaques, tangles, brain atrophy, cognitive decline. RESULTS Plasma NT1‐tau significantly increased...
Abstract Extracellular β-amyloid plaques and intracellular neurofibrillary tau tangles are the primary hallmarks of Alzheimer's disease. β-Amyloid pathology can be directly quantified by positron emission tomography imaging or indirectly measuring decrease cerebrospinal fluid β-amyloid42/β-amyloid40 ratio. Although these two biomarkers may considered interchangeable, they sometimes show discordance, particularly in early stage Individuals with positive only at amyloidosis compared to those...
The aim of this study was to determine whether antibodies induced by human papillomavirus (HPV) type 31 L1/L2 virus-like particles (VLPs) could cross-react with VLPs the closely related HPV-16 and distantly HPV-11, investigate potential role L2 protein in inducing cross-neutralizing antibodies. Antisera were prepared from rabbits immunized intact or denatured HPV-31 VLPs. Cross-reaction cross-neutralization analysed Western blotting ELISA, haemagglutination inhibition, respectively. results...
Background: Matrine (MAT) exhibits higher efficacy of chemotherapy when it is combined with other chemotherapeutic drugs; however, the therapeutic matrine in combination docetaxel (DOC) for prostate cancer, or even androgen-independent remains poorly understood and underlying molecular mechanisms have not yet been clearly defined. In present study, we investigated whether can strengthen anti-cancer effect. Methods: this 7 groups were established, including (1) blank control group (cells)....
To explore posttraumatic stress disorder symptoms (PTSD) after respiratory insufficiency in patients with myasthenia gravis (MG). The investigation was made 134 adult MG, insufficiency, between January 2012 and 2016 had a return visit one year. finished this study 69 (51.5%) PTSD. Anxiety (HADS-A ≥ 8, HADS: Hospital Depression Scale) (OR 2.585,95% CI 1.102–6.061, p = 0.029), depression (HADS-D 8) 3.200, 95% 1.395–7.342, 0.006) were associated greater probabilities of screening positive for...
Background Fructosamine (FRA) is widely used for diabetes monitor and control as a glycemic marker, especially in patients whom the measurement of HbA1c may be biased or even unreliable. However, FRA reference intervals based on Asian population features still keep seldom reported. The objective this study was to establish adult Beijing, China. Methods A total 1,497 healthy subjects were separated into three groups by gender age. Subsequently, levels collected serum samples from individuals...
The research aimed to identify the active component from Punica granatum L. alleviate ischemia/reperfusion injury and clarify underlying mechanism of alleviating injury.The SH-SY5Y cell model oxygen-glucose deprivation/reoxygenation (OGD/R) was established simulate injury. According strategy bioassay-guided isolation, punicalin identified. Flow cytometry Western blotting were employed evaluate effects OGD/R and/or on cycle arrest. Immunofluorescence assay applied assess nucleus...
Abstract Rhaponticin is a constituent isolated from numerous medicinal herbs. It has been reported earlier that rhaponticin possesses biological effects like antiallergic, antidiabetic, hepatoprotective, and antithrombosis. The goal of this exploration was to scrutinize the therapeutic potential on ovariectomy (OVX)‐triggered osteoporosis in rats. Female Sprague Dawley rats were arbitrarily allocated sham‐operated control group I, II, which underwent OVX, groups III IV OVX administered with...
To evaluate the effect of teriparatide on life quality in patients with postmenopausal osteoporosis.
Abstract Background N‐methylderivative of Amyvid ( 18 F‐D3FSP) displayed very similar β‐amyloid (Aβ) targeting properties to the F‐florbetapir tracer, but it is not well established about performance F‐D3FSP Aβ positron emission tomography (PET) imaging in Alzheimer’s disease (AD). Method In this study, we recruited 142 Greater‐Bay‐Area Healthy Aging Brain Study (GHABS) participants from community and completed Simoa plasma biomarkers, MRI imaging, PET cognitive assessments. images were...