A5091875924- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Cholinesterase and Neurodegenerative Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neuroscience and Neuropharmacology Research
- Trace Elements in Health
- Drug Transport and Resistance Mechanisms
- Diet, Metabolism, and Disease
- Cerebrospinal fluid and hydrocephalus
- Advanced Glycation End Products research
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Medicinal Plants and Bioactive Compounds
- Liver Disease Diagnosis and Treatment
- Receptor Mechanisms and Signaling
Daping Hospital
2020-2024
Army Medical University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Immunosenescence contributes to systematic aging and plays a role in the pathogenesis of Alzheimer's disease (AD). Therefore, objective this study was investigate potential immune rejuvenation as therapeutic strategy for AD. To achieve this, systems aged
Abstract Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role pathogenesis sporadic Alzheimer’s disease (AD). The roles blood monocytes development AD remain unclear. In this study, we sought to investigate alterations Aβ phagocytosis function peripheral during ageing and patients. A total 104 cognitively normal participants aged 22–89 years, 24 patients, 25 age- sex-matched (CN) subjects, 15 Parkinson’s patients (PD), CN subjects were recruited. uptake by was measured its...
The role of α1 adrenergic receptors (α1-ARs) signaling pathway in the pathogenesis Alzheimer's disease (AD) has rarely been investigated. Clarifying pathophysiological functions α1-ARs AD brain is helpful for better understanding and screening novel therapeutic targets AD. This study included 2 arms vivo investigations: 1) 6-month-old female APPswe/PS1 mice were intravenously treated with AAV-PHP.eB-shRNA (α1-ARs)-GFP or AAV-PHP.eB-GFP 3 months. 2) 3-month-old daily 0.5 mg/kg terazosin an...
Recent studies show that fibrinogen plays a role in the pathogenesis of Alzheimer’s disease (AD), which may be crucial to neurovascular damage and cognitive impairment. However, there are few clinical on relationship between AD. 59 11 C-PiB-PET diagnosed AD patients 76 age- gender-matched cognitively normal controls were included analyze correlation plasma β-amyloid (Aβ) tau levels with levels. 35 cerebrospinal fluid (CSF) samples further CSF Aβ In patients, positively correlated Aβ40 Aβ42...
CD22 has been suggested to contribute Alzheimer’s disease (AD) pathogenesis by inhibiting microglial amyloid β (Aβ) phagocytosis. Soluble (sCD22) generated cleavage from cell membranes may be a marker of inflammation and dysfunction; but alterations sCD22 levels in AD their correlation with biomarkers remain unclear. Plasma were measured cognitively normal non-AD participants patients preclinical dementia Chinese cohort the Australian Imaging, Biomarkers Lifestyle Flagship Study Ageing....
The prevalence of non-alcoholic fatty liver disease (NAFLD), which is developed from hepatic steatosis, increasing worldwide. However, no specific drugs for NAFLD have been approved yet. To observe the effects Rho, a fraction Rhodiola crenulate, on three mouse models with characteristics were used including high-fat diet (HFD)-induced obesity (DIO) mice, KKAy and HFD combined tetracycline stimulated Model-T mice. Hepatic lipid accumulation was determined via histopathological analysis and/or...
Abstract Background The role of α1 adrenergic receptors (α1-ARs) signaling pathway in the pathogenesis Alzheimer’s disease (AD) has rarely been investigated. Clarifying pathophysiological functions α1-ARs AD brain is helpful for better understanding and screening novel therapeutic target AD. Methods This study included 2 arms vivo investigations: 1) 6-month-old female APPswe/PS1 mice were intravenously treated with AAV-PHP.eB-shRNA (ARs)-GFP or AAV-PHP.eB-GFP 3 months. 2) 3-month-old daily...
Abstract Background: Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role pathogenesis sporadic Alzheimer’s disease (AD). The roles blood monocytes, counterparts microglia periphery, development AD remain unclear. In this study, we sought to investigate alterations Aβ phagocytosis function peripheral monocytes during ageing and patients. Methods: A total 104 cognitively normal participants aged 22 89 years old, patients, age- sex-matched (CN) subjects, 15 Parkinson’s...
Abstract Background Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role pathogenesis sporadic Alzheimer’s disease (AD). The roles blood monocytes, counterpartsof microglia periphery, development AD remain unclear. In this study, we sought to investigate alterations Aβ phagocytosis function peripheral monocytes during ageing and patients. Methods: A total of104 cognitively normal participants aged 22 89 years old, patients, age- sex-matched (CN) subjects, 15 Parkinson’s...
Abstract Background Alzheimer’s disease (AD) is the most popular neurodegenerative affecting cognitive functions of elderly population. Neuronal apoptosis an important pathological process during development AD. The Bcl-2-interacting mediator cell death (Bim) mediates Amyloid-beta (Aβ)-induced neuronal apoptosis. Naturally occurring antibodies against Bim (NAbs-Bim) exist in human blood, with their levels and unknown Methods This study investigated clinical relevance plasma NAbs-Bim to AD 55...