A5101525806- Lung Cancer Treatments and Mutations
- Alzheimer's disease research and treatments
- HER2/EGFR in Cancer Research
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Inflammatory mediators and NSAID effects
- Colorectal Cancer Treatments and Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Magnesium in Health and Disease
- Click Chemistry and Applications
- Biosensors and Analytical Detection
- Genetics and Neurodevelopmental Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chronic Myeloid Leukemia Treatments
- Fungal Infections and Studies
- Renal and related cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Glycation End Products research
- Gastric Cancer Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginkgo biloba and Cashew Applications
- Microbial infections and disease research
- DNA Repair Mechanisms
- Hedgehog Signaling Pathway Studies
- Peptidase Inhibition and Analysis
Army Medical University
2020-2025
Daping Hospital
2025
Xuzhou Medical College
2023
Kunming Third People's Hospital
2023
Xian Yang Central Hospital
2023
Ruijin Hospital
2022
Affiliated Hospital of Qingdao University
2020-2021
Qingdao University
2020-2021
Shanxi Medical University
2014-2021
Second Hospital of Shanxi Medical University
2014-2021
Abstract Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role pathogenesis sporadic Alzheimer’s disease (AD). The roles blood monocytes development AD remain unclear. In this study, we sought to investigate alterations Aβ phagocytosis function peripheral during ageing and patients. A total 104 cognitively normal participants aged 22–89 years, 24 patients, 25 age- sex-matched (CN) subjects, 15 Parkinson’s patients (PD), CN subjects were recruited. uptake by was measured its...
Abstract INTRODUCTION This study was undertaken to evaluate the diagnostic performance of a novel plasma phosphorylated tau (p‐tau) 217/amyloid beta (Aβ) 42 ratio test for Alzheimer's disease (AD). METHODS The Lumipulse G p‐tau217/Aβ42 evaluated using Aβ and positron emission tomography (PET) as reference standards in clinic cohort ( n = 391) community 121). RESULTS Plasma exhibited high abnormal statuses PET (area under curve [AUC]: 0.963 0.966) (AUC: 0.947 0.974), which were clinically...
Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, with high incidence and mortality. To improve curative effect prolong survival patients, it necessary to find new biomarkers accurately predict prognosis patients explore strategy treat high-risk LUAD.A comprehensive genome-wide profiling analysis was conducted using a retrospective pool LUAD patient data from previous datasets Gene Expression Omnibus (GEO) including GSE18842, GSE19188, GSE40791 GSE50081 The...
High human telomerase reverse transcriptase (hTERT) expression is related to severe Colorectal Cancer (CRC) progression and negatively CRC patient survival. Previous studies have revealed that hTERT can reduce cancer cellular reactive oxygen species (ROS) levels accelerate progression; however, the mechanism remains poorly understood. NFE2-related factor 2 (NRF2) a molecule plays significant role in regulating ROS homeostasis, but whether there correlation between NRF2 unclear. Here, we...
The incidence of psittacosis infection has gradually increased in recent years. Metagenomic next-generation sequencing (mNGS) can be used to comprehensively identify the total DNA and RNA content microbiome, as well both known unexpected pathogens within 24 hours. We diagnosed treated six patients with using mNGS, two whom developed severe disease most presented pulmonary symptoms. One young female also irregular vaginal bleeding myocarditis. Patients underlying gastric disorders first...
Graphical illustration of a multifunctional lipoprotein-derived RLA-rHDL@ANG nanostructure for Alzheimer's treatment through promoting Aβ degradation and alleviating oxidative stress.
Lung cancer is a major health concern worldwide because of its increasing incidence and mortality. This study aimed to clarify the association between mesenchymal-epithelial transition (MET) genomic alterations clinical characteristics lung cancer.We collected data from 5,008 patients with diagnosed treated January 2017 July 2021 at Affiliated Hospital Qingdao University. Genomic in MET gene, including exon 14 skipping mutation amplification, were detected using amplification refractory...
Background:Cyclooxygenase-2 (Cox-2) is critical for tumor invasion, angiogenesis, and poor prognosis in many human cancers. It was reported to be an abnormal expression malignancies, including basal cell carcinoma (BCC). However, the prognostic significance of cox-2 BCC still unclear. The aim this study investigate roles patients with BCC. Methods: We detected both at mRNA protein level tissue adjacent normal tissues from 180 by quantitative real-time polymerase chain reaction (qRT-PCR)...
This study was purposed to investigate the relation of CD25 with acute B cell lymphoblastic leukemia (B-ALL) and its clinical significance. A totol 88 newly diagnosed B-ALL patients were enrolled in this study. The immunophenotype leukemic myeloblasts detected by flow cytometry, including interleukin 2 receptor α chain (CD25), β (CD122), γ (CD132), CD19, CD20, CD10, CD34, CDIgM, CD79a, CD22 CDTDT. expression BCR/ABL fusion gene qualitative PCR. IL2RA (CD25 gene) real-time RT-PCR. results...
This study to analyze the clinical characteristics of patients with invasive pulmonary aspergillosis (IPA) following influenza A (H1N1) infection.We retrospectively analyzed 10 cases IPA H1N1 infection. The manifestations, laboratory examination results, chest computed tomography, and treatments were analyzed.Clinical manifestations: all had typical flu-like symptoms at onset disease, among which 7 developed dyspnea in late stage, 8 hemoptysis. Laboratory examination: absolute percentage...
113 Background: Although the clinical trial WJOG7112G was failed to prove weekly paclitaxel with trastuzumab in patients HER2-positive gastric or gastro-esophageal junction (GEJ) cancer refractory is better than alone, there are limited data concerning efficacy of continuing beyond first-line progression real world. Methods: This retrospective study included all consecutive advanced GEJ adenocarcinoma who received a chemotherapy first-line, second-line, third-line therapy between 2010 and...
Objective To investigate the learning curve of contrast-enhanced ultrasonography (CEUS) in sentinel lymph node(SLN) breast cancer and provide a theoretical basis for leaners to learn SLN CEUS. Methods The multi-center study CEUS was planned by Sichuan Cancer Hospital. According uniform inclusion exclusion criteria, 511 patients with complete clinical data follow-up results from 9 hospitals Multi-center were included this study. inspection time, divided into 3 groups named as group A...
Background: Human epidermal growth factor receptor 2 (HER2)-positive breast cancer tends to metastasize and is associated with poor prognosis.Anti-HER2 treatment combined chemotherapy or endocrine therapy often used for HER2-positive metastatic (MBC).For later lines of in MBC, there no standard treatment.We investigated the efficacy pyrotinib, a new irreversible tyrosine kinase inhibitor (TKI) targeting receptor, HER2, HER4, lapatinib-resistant MBC patients.Methods: This retrospective...
Non-small cell lung cancer is the main part of cancer.The targeted therapies non-small have been rapidly developing for past decade.And it first-line therapy patients with sensitizing epidermal growth factor receptor mutations.The recent researches indicated that besides classic mutations, rare mutations and compound may be related to sensitivity receptor-tyrosine kinase inhibitor.This review summarizes progress S768I in treatment cancer. Key words: Non-small cancer; S768I; Compound...
e15664 Background: Colorectal cancer (CRC) is a heterogeneous disease. Distinct features of tumors including sidedness and microsatellite instability status, high (MSI-H) or stable (MSS) have been highlighted. MSI-H confers favorable prognosis predictive response to checkpoint blockade therapy. While left sided CRC may superior right CRC, the biologic basis for this difference unknown. We hypothesize that improved in due immune tumor microenvironment (TME). Methods: 24 patients with stage...
Abstract Background The outcomes of hepatocellular carcinoma (HCC) remain poor despite dramatic improvements in treatment, and novel prognostic biomarkers are urgently needed to ameliorate the situation. Cell division cycle protein 45 (CDC45) plays a key role DNA replication, which is considered be involved tumorigenesis has become new marker. This study investigated CDC45 expression tumour tissues defined its value HCC patients. Methods Differential transcriptional proteomic profiles were...