A5046597600- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Alzheimer's disease research and treatments
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Advanced Decision-Making Techniques
- Radiomics and Machine Learning in Medical Imaging
- Dementia and Cognitive Impairment Research
- AI in cancer detection
- Nuclear Receptors and Signaling
- Restless Legs Syndrome Research
- Advanced Neuroimaging Techniques and Applications
- RNA regulation and disease
- Global Cancer Incidence and Screening
- Autophagy in Disease and Therapy
- Autism Spectrum Disorder Research
- Ginkgo biloba and Cashew Applications
- Olfactory and Sensory Function Studies
- MicroRNA in disease regulation
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Ultrasound and Hyperthermia Applications
Huashan Hospital
2016-2025
Fudan University
2016-2025
Sichuan University
2025
State Key Laboratory of Medical Neurobiology
2022-2024
Sun Yat-sen Memorial Hospital
2011-2024
Sun Yat-sen University
2012-2024
Guizhou Institute of Technology
2022-2024
Donghua University
2007-2023
Yueyang Hospital
2022
Shanghai University of Traditional Chinese Medicine
2022
Abstract There is currently no reliable and easily applicable diagnostic marker for Parkinson’s disease (PD). The aims of the present study were to compare expression profiles microRNA29 family (miR-29s) in blood serum from patients with PD healthy controls clarify whether miR-29s correlated severity, duration or L-dopa therapy depends on gender age patients. levels 80 unaffected assessed by reverse transcription-quantitative real-time PCR. PCR products confirmed cloning sequencing....
ABSTRACT Background 18 F‐APN‐1607 is a novel tau PET tracer characterized by high binding affinity for 3‐ and 4‐repeat deposits. Whether imaging clinically useful in PSP remains unclear. Objectives The objective of this study was to investigate the clinical utility diagnosis, differential assessment disease severity patients with PSP. Methods We enrolled 3 groups consisting (n = 20), α‐synucleinopathies (MSA predominant parkinsonism, n 7; PD, 10), age‐ sex‐matched healthy controls 13)....
Human post mortem studies have described the topographical patterns of tau pathology in progressive supranuclear palsy (PSP). Recent advances PET tracers are expected to herald next era PSP investigation for early detection living brains. This study aimed investigate whether 18F-Florzolotau imaging may capture distribution and regional vulnerability PSP, devise a novel image-based staging system.The cohort consisted 148 consecutive patients with who had undergone imaging. The rating scale...
Rapid eye movement sleep behavior disorder (RBD) is increasingly recognized in patients with tauopathies, but its significance and underpinnings remain unclear. To address this gap, we investigated the prevalence of self-reported RBD progressive supranuclear palsy (PSP) explored clinical imaging correlates using 18F-florzolotau PET imaging. We consecutively enrolled meeting 2017 Movement Disorder Society criteria for PSP at a Chinese tertiary hospital between May 2019 March 2022. Patients...
Abstract Idiopathic rapid eye movement sleep behaviour disorder (RBD) is now recognized as an early manifestation of α-synucleinopathies. Increasing experimental studies demonstrate that manipulative lesion or inactivation the neurons within sublaterodorsal tegmental nucleus (also known subcoeruleus in humans) can induce RBD-like behaviours animals. As current RBD animal models are not established on basis α-synucleinopathy, they do represent pathological substrate idiopathic and thus cannot...
Many patients with breast cancer still relapse after curative treatment. How to identify the ones high risk remains a critical problem. Circulating tumor DNA (ctDNA) has recently become promising marker monitor burden. Whether ctDNA can be used predict response and prognosis in receiving neoadjuvant chemotherapy (NAC) is unknown. Our study aimed evaluate clinical value of presence dynamic change treated NAC.Fifty-two early who underwent NAC were prospectively enrolled. Serial plasma samples...
This work attempts to decode the discriminative information in dopamine transporter (DAT) imaging using deep learning for differential diagnosis of parkinsonism.This study involved 1017 subjects who underwent DAT PET ([11C]CFT) including 43 healthy and 974 parkinsonian patients with idiopathic Parkinson's disease (IPD), multiple system atrophy (MSA) or progressive supranuclear palsy (PSP). We developed a 3D convolutional neural network learn distinguishable features parkinsonism. A...
Neuroimaging indicators of Parkinson disease have been developed and applied in clinical practices. Dopaminergic imaging reflects nigrostriatal dopaminergic dysfunction, metabolic network offers disease-related changes at a system level. We aimed to elucidate the association between Parkinsonian symptoms neuroimaging, interactions different techniques.We conducted dual-tracer PET study for combined assessments binding (C-CFT) glucose metabolism (F-FDG) 103 participants with (65 male 38...
The clinical presentations of early idiopathic Parkinson's disease (PD) substantially overlap with those atypical parkinsonian syndromes like multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). This study aimed to develop metabolic imaging indices based on deep learning support the differential diagnosis these conditions. <b>Methods:</b> A benchmark Huashan PET (HPPI, China) database including 1275 patients 863 non-parkinsonian subjects <sup>18</sup>F-FDG images was...
ABSTRACT Background Recent development in tau‐sensitive tracers has sparkled significant interest tracking tauopathies using positron emission tomography (PET) biomarkers. However, the ability of 18 F‐florzolotau PET imaging to topographically characterize tau pathology corticobasal syndrome (CBS) remains unclear. Further, question as whether disease‐level differences exist with other neurodegenerative is still unanswered. Objective To analyze topographical patterns living brains patients...
Abstract Background Schizophrenia is a serious mental illness characterized by sensory, cognitive, and emotional disorders. It often occurs in young middle-aged individuals can cause significant stress to the patient, their family, society. may also lead symptoms such as sleep disorders, lack of concentration, memory loss, which turn affect patient’s brain function cognitive abilities. At present, treatment schizophrenia mainly relies on taking antipsychotic drugs, but it requires long-term...
Abstract Background Amyloid precursor‐like protein 1 (APLP1) is involved in pathological α‐synuclein transmission, but its role Parkinson's disease (PD) progression has not been explored. Objective This study investigates APLP1 as a potential predictor for motor and cognitive deterioration PD. Methods Plasma levels were measured PD patients from the Huashan Hospital Disease (HSPD) Progression Markers Initiative (PPMI) cohorts. A total of 916 participants recruited HSPD cohort, 171 PPMI...
Background Asymmetry in motor dysfunction and associated dopaminergic deficit is a common characteristic of Parkinson's disease (PD), yet potential explanations remain mysterious. Hereby, we assessed whether asymmetry the nasal cavity related to PD patients. Methods This cross-sectional, multi-center observational study included 761 patients from three cohorts. First, analyzed data Huashan Parkinsonian PET Imaging Database (March 2011 February 2020), which served as primary cohort (n=333)....
The leucine-rich repeat kinase 2 (LRRK2) gene is one of the most common genetic causes autosomal dominant Parkinson's disease (PD) and a risk factor for sporadic PD. However, aged mice with LRRK2 point mutations fail to exhibit age-related PD-associated behavioral pathological impairments. We generated novel mouse model harboring LRRK2.p.N1437D mutation (c.4309 A > G; NM_98578). Here, homozygous N1437D mutation, but not heterozygous led an increase in autophosphorylation, substrate...
Many sensing/catalytic applications in nanotechnology require a programmed assembly of nanospheres/nanorods onto surfaces. The gold nanorods, formed by seed-mediated, surfactant-assisted synthesis protocol, are stabilized solution due to surface modification the surfactant cetyltrimethylammonium bromide. DNA-templated self-assembly nanorods with different aspect ratios at DNA concentration values has been studied using transmission electron microscopy. Under appropriate conditions such as...