A5004564984- Nerve injury and regeneration
- Parkinson's Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Conducting polymers and applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Tea Polyphenols and Effects
- RNA regulation and disease
- Phytoestrogen effects and research
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Neurogenesis and neuroplasticity mechanisms
- Intensive Care Unit Cognitive Disorders
- Analytical Chemistry and Chromatography
- Neuroscience and Neuropharmacology Research
- Mesenchymal stem cell research
- Garlic and Onion Studies
- RNA Interference and Gene Delivery
- Amyotrophic Lateral Sclerosis Research
- Cardiac Health and Mental Health
- Food Quality and Safety Studies
- Tryptophan and brain disorders
- Phytochemical compounds biological activities
Shandong Academy of Sciences
2025
Qilu University of Technology
2025
Huashan Hospital
2020-2022
State Key Laboratory of Medical Neurobiology
2014-2022
Shanghai Jiao Tong University
2021-2022
Fudan University
2018-2022
Shanghai Sixth People's Hospital
2021-2022
Shenyang Pharmaceutical University
2018-2021
Shanghai Medical College of Fudan University
2014-2020
Abstract There is currently no reliable and easily applicable diagnostic marker for Parkinson’s disease (PD). The aims of the present study were to compare expression profiles microRNA29 family (miR-29s) in blood serum from patients with PD healthy controls clarify whether miR-29s correlated severity, duration or L-dopa therapy depends on gender age patients. levels 80 unaffected assessed by reverse transcription-quantitative real-time PCR. PCR products confirmed cloning sequencing....
Microglial activation and inflammation are associated with progressive neuronal apoptosis in neurodegenerative disorders such as Parkinson's disease (PD). γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter central nervous system, has recently been shown to play an role immune system. Tiagabine, a piperidine derivative, enhances GABAergic transmission by inhibiting GABA transporter 1 (GAT 1). In present study, we found that tiagabine pretreatment attenuated microglial...
Fungal chlamydospores are asexual spores formed by fungi under adverse conditions and could be used in biological pretreatment for biogas projects fed lignocellulosic substrates. In this study, Trichoderma viride (Tv) were as the agent to enhance methane yield of spent mushroom substrates (SMSs). Lignocellulosic composition, methanogenesis performance, anaerobic microbial communities investigated different Tv durations (0 h, 12 24 48 96 192 h). The results showed that optimal duration was...
We aimed to examine whether miRNA-29s (miR-29s) in serum are associated with cognitive impairment Parkinson's disease (PD). Thirty-nine PD patients normal cognition (PD-NC), 37 mild (PD-MCI), 22 dementia (PDD) and 40 healthy controls were recruited. Detailed clinical evaluations a schedule of neuropsychological tests administered all patients. MiR-29s expression samples was assessed using reverse-transcription quantitative real-time PCR. found that the levels three miR-29s PDD group...
Studies reveal a linkage of miR-29s in aging and Parkinsonâs disease (PD). Here we show that the serum levels 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice exhibited dynamic changes. The role miR-29b2/c was studied utilizing gene knockout (miR-29b2/c KO). KO were characterized by markedly lighter weight, kyphosis, muscle weakness abnormal gait, when compared with wild-type (WT) mice. WT also developed apparent dermis thickening adipose tissue reduction. However,...
Stem cell transplantation is a promising strategy with great potential to treat Parkinson's disease (PD). Nevertheless, improving the delivery route and optimising implanted cells are necessary increase therapeutic effect. Herein, we investigated whether intranasal of bone marrow stromal (BMSCs) has beneficial effects in PD mouse model BMSCs could be enhanced by preconditioning fasudil.A was developed intraperitoneally administering 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Mice...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of midbrain dopaminergic neurons. The miR-29s family, including miR-29a and miR-29b1 as well miR-29b2 miR-29c, are implicated in aging, metabolism, neuronal survival, neurological disorders. In this study, the roles miR-29a/b1 aging PD were investigated. knockout mice (named 29a KO hereafter) their wild-type (WT) controls used to analyze aging-related phenotypes. After challenged with...
Abstract A valine carbamate prodrug of daidzein was synthesized to improve its bioavailability because the poor solubility and low permeability daidzein. To evaluate pharmacokinetic behavior prodrug, a sensitive high‐throughput method developed validated for simultaneous determination in rat plasma. The samples were extracted by ethyl acetate then analyzed supercritical fluid chromatography with electrospray ionization tandem mass spectrometry method. separation achieved an ACQUITY UPC 2 ™...
Epidemiological and clinicopathological studies indicate that there is a high risk for chronic heart failure (CHF) in patients suffering from neuropsychiatric disorders, such as depression. However, it unclear whether CHF causes depression, the underlying mechanisms of this association remain largely unknown. In study, mice with myocardial infarction were used to investigate behavioral alterations well changes brain-heart axis. During first 6 months, abnormalities behaviors detected CHF....
Abstract A valine carbamate prodrug of naringenin (NAR) called 4'V was synthesized to enhance its oral bioavailability because low water solubility and poor membrane permeability NAR. This study developed fully validated a sensitive, rapid, robust HPLC–MS/MS method for the simultaneous determination NAR 4’V in plasma. The analytes were treated using liquid–liquid extraction, separated on Phenomenex Kinetex XB‐C 18 column, detected triple‐quadrupole tandem mass spectrometer equipped with an...
Background: A valine carbamate prodrug (7-P) was designed to enhance the low bioavailability of daidzein due its water solubility and membrane permeability. Here, we developed a high-throughput HPLC–MS/MS method measure 7-O-glucuronide after oral administration or 7-P. Materials & methods: validated successfully applied assess pharmacokinetic behavior orally administrating The on selectivity, linearity (r ≥ 0.995), precision (relative standard deviation <11.4%), accuracy error <7.1%),...
Abstract Background Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of midbrain dopaminergic neurons. The miR-29s family, including miR-29a and miR-29b1 as well miR-29b2 miR-29c , are implicated in aging, metabolism, neuronal survival, neurological disorders. In this study, the roles miR-29a/b1 aging PD were investigate. Methods knockout mice (named 29a KO hereafter) their wild-type (WT) controls used to analyze aging-related phenotypes....