A5090107253- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Cancer-related molecular mechanisms research
- Gestational Diabetes Research and Management
- Nerve injury and regeneration
- Simulation Techniques and Applications
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- RNA modifications and cancer
- Health, Environment, Cognitive Aging
- Topic Modeling
- Circular RNAs in diseases
- Business Process Modeling and Analysis
- Heavy metals in environment
- Nuclear Receptors and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Insect and Pesticide Research
- Pregnancy and preeclampsia studies
- Opinion Dynamics and Social Influence
- Sentiment Analysis and Opinion Mining
- Neuroscience and Neuropharmacology Research
- Telomeres, Telomerase, and Senescence
- Neuroinflammation and Neurodegeneration Mechanisms
Guangxi Medical University
2014-2025
Shanghai Jiao Tong University
2024
Fujian Agriculture and Forestry University
2021-2024
National University of Singapore
2021
Tongji University
2021
East China Normal University
2019
Fudan University
2018-2019
State Key Laboratory of Medical Neurobiology
2014-2019
Shanghai Medical College of Fudan University
2014-2019
Zhejiang Gongshang University
2018
The paucity of selective agonists for TWIK-related acid-sensitive K+ 3 (TASK-3) channel, a member two-pore domain (K2P) channels, has contributed to our limited understanding its biological functions. By targeting druggable transmembrane cavity using structure-based drug design approach, we discovered biguanide compound, CHET3, as highly allosteric activator TASK-3-containing K2P including TASK-3 homomers and TASK-3/TASK-1 heteromers. CHET3 displayed potent analgesic effects in vivo variety...
Abstract Background Owing to high genetic diversities of tumor cells and low response rate standard chemotherapy, patients with triple negative breast cancer (TNBC) have short progression-free survivals poor outcomes, which need explore an effective approach improve therapeutic efficacy. Methods Novel gadolinium doped carbon dots (Gd@CDs) been designed prepared through hydrothermal method 3,4-dihydroxyhydrocinnamic acid, 2,2′-(ethylenedioxy)bis(ethylamine) chloride. The synthesized...
Background: This study searched for immune-related long noncoding RNAs (lncRNAs) to predict the prognosis of patients with cervical cancer. Method: We obtained immunologically relevant lncRNA expression profiles and clinical follow-up data from cancer The Cancer Genome Atlas database Molecular Signatures Database. Cervical were randomly divided into a training group, testing group combined group. immune prognostic signature was constructed by Least Absolute Shrinkage Selection Operator Cox...
Growing evidence has revealed the impacts of exposure to fine particulate matter (PM
Microglial activation and inflammation are associated with progressive neuronal apoptosis in neurodegenerative disorders such as Parkinson's disease (PD). γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter central nervous system, has recently been shown to play an role immune system. Tiagabine, a piperidine derivative, enhances GABAergic transmission by inhibiting GABA transporter 1 (GAT 1). In present study, we found that tiagabine pretreatment attenuated microglial...
The physiological functions of micronutrients in neurodevelopment are well documented, but their protective effects on neurodevelopmental disorders remain controversial. We assessed the associations between and three main disorders, that is, autism spectrum disorder (18,381 cases), attention-deficit/hyperactivity (38,691 Tourette’s syndrome (4,819 using two-sample Mendelian randomization analyses. In addition, we estimated mediation role brain imaging-derived phenotypes ( n = 33,224) these...
Preterm birth (PTB), a serious adverse outcome, is the leading cause of perinatal mortality and morbidity. Bisphenols induce endocrine disruption that spreads across placenta, which may affect fetal growth development. However, effects bisphenols on PTB, particularly their combined effects, remain unknown. This study investigated association between prenatal bisphenol exposure PTB. Study participants were 2023 mother-infant pairs selected from Guangxi Zhuang Birth Cohort. Maternal serum...
Prenatal exposure to outdoor air pollution have been associated with birth outcomes. However, there is limited evidence on the adverse effects of household indoor worldwide, much less in rural areas China. This study aimed explore associations environmental factors (primary cooking fuel, housing renovation, and home ventilation) four outcomes (preterm (PTB), small for gestational age (SGA), low weight (LBW), term (T-LBW)). We conducted a cohort involving 10,324 pregnancies women who...
Telomere length (TL) is an important biomarker of biological aging and disease that may be affected by prenatal exposure to environmental pollutants. Birth seasons have been linked reproductive immune-related diseases. Prenatal per- polyfluoroalkyl substance (PFAS) has associated with adverse birth outcomes, but the effects PFAS on newborn TL are poorly understood.To explore individual combined maternal TL, exploration interaction between TL.Between June 2015 May 2018, a total 499...
To assess the association between exposure to tobacco, heavy metals and phthalate on early pregnancy missed abortion.42 women with abortion 57 matched controls (women normal pregnancies) were recruited March May 2012, from Department of Gynecology Obstetrics, First Affiliated Hospital Guangxi Medical University People Zhuang Autonomous Region. The questionnaire survey was carried learn about basic conditions, as well smoking history all participants. levels metal, compared 2 groups by...
Neuroinflammation, as an important pathological characteristic of Parkinson's disease (PD), is primarily mediated by activated astrocytes and microglia. Neuron-restrictive silencer factor/repressor element 1 (RE1)-silencing transcription factor (NRSF/REST) regulates many genes signal pathways involved in the inflammatory process astrocytes. In present study, we established GFAP-Cre:NRSFflox/flox conditional knockout (cKO) mice. The expression inflammation-associated molecules were measured...