A5048845709- Cancer-related molecular mechanisms research
- Birth, Development, and Health
- RNA modifications and cancer
- Per- and polyfluoroalkyl substances research
- Effects and risks of endocrine disrupting chemicals
- Telomeres, Telomerase, and Senescence
- Circular RNAs in diseases
- Gestational Diabetes Research and Management
- Toxic Organic Pollutants Impact
- Ferroptosis and cancer prognosis
- Nutritional Studies and Diet
- Heavy Metal Exposure and Toxicity
- Lipid metabolism and disorders
- Chemical Analysis and Environmental Impact
- Cancer Risks and Factors
- Fluoride Effects and Removal
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- RNA Research and Splicing
- MicroRNA in disease regulation
Guangxi Medical University
2021-2024
National University of Singapore
2021
Abstract Background Long non-coding RNAs (lncRNAs) are involved in the development of hepatocellular carcinoma (HCC). We aimed to investigate function LINC01146 HCC. Methods The expression HCC tissues was explored via Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases verified using quantitative real-time polymerase chain reaction (qRT–PCR) our cohort. Kaplan–Meier analysis used assess relationship between prognosis patients. Cell Counting Kit 8, colony formation assays,...
Increasing evidence shows that liver-specific long non-coding RNAs (lncRNAs) play important roles in the development of hepatocellular carcinoma (HCC). We identified a novel lncRNA, FAM99A, and examined its clinical significance biological functions HCC.The expression level value FAM99A HCC were using The Cancer Genome Atlas (TCGA), International Consortium (ICGC), Gene Expression Omnibus (GEO) databases, further verified quantitative real-time polymerase chain reaction (qRT-PCR) our cohort....
Abstract Background Telomere length (TL) is variable at birth and inversely associated with body mass index (BMI) in adulthood. A growing number of evidences suggested that a higher maternal pre-pregnancy BMI results adverse offspring health outcomes, especially shorter newborn TL. However, newborn’s genetic endowment equally derived from both parents, the association between parental TL has been rarely discussed. We aimed to determine Methods total 1082 parent-newborn pairs were recruited...
Background: Circular RNAs (circRNAs) have been demonstrated to be closely related the carcinogenesis of human cancer in recent years. However, molecular mechanism circRNAs pathogenesis hepatocellular carcinoma (HCC) has not fully elucidated. We aimed identify critical and explore their potential regulatory network HCC. Methods: The robust rank aggregation (RRA) algorithm weighted gene co-expression analysis (WGCNA) were conducted unearth differentially expressed (DEcircRNAs) expression...
Background: Prenatal exposure to perfluoroalkyl substances (PFASs) is associated with adverse birth outcomes, but much less known about the combined effect of PFASs on PTB.Objectives: In this study, we estimated association single- and multiple-exposure PFAS PTB identified main contributors from mixture.Methods: A total 1597 mother-infant pairs were recruited Guangxi Zhuang Birth Cohort. Concentrations nine in maternal serum obtained before 22 weeks gestation examined by ultrahigh liquid...
Abstract A growing number of epidemiologic studies have estimated the associations between endocrine-disrupting chemicals and gestational diabetes mellitus (GDM). However, reports on association bisphenol (BPA) substitutes GDM are limited. This investigation aimed to explore maternal serum BPA, B (BPB), F (BPF), S (BPS), tetrabromobisphenol (TBBPA) with risk GDM. nested case-control study was performed among 500 pregnant women. Associations levels were assessed by conditional logistic...
Abstract Background: Telomere length (TL) is variable at birth and inversely associated with body mass index (BMI) in adulthood. A growing number of evidences suggested that a higher maternal pre-pregnancy BMI results adverse offspring health outcomes, especially shorter newborn TL. However, newborn’s genetic endowment equally derived from both parents, the association between parental TL has been rarely discussed. We aimed to determine Methods: total 1082 parent-newborn pairs were recruited...
Abstract BackgroundLong non-coding RNAs (lncRNAs) have been proven to be involved in the development of hepatocellular carcinoma (HCC). We aimed investigate function LINC01146 HCC.MethodsThe expression HCC tissues was explored via Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, verified using quantitative real-time polymerase chain reaction (qRT-PCR) our cohort. Kaplan-Meier analysis used assess relationship between prognosis patients. Cell Counting Kit 8, colony...